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  4. Recombinant Human T-cell leukemia homeobox protein 1 (TLX1)

Recombinant Human T-cell leukemia homeobox protein 1 (TLX1)

  • 中文名称：
    人TLX1重组蛋白
  • 货号：
    CSB-YP023609HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TLX1重组蛋白
  • 货号：
    CSB-EP023609HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TLX1重组蛋白
  • 货号：
    CSB-EP023609HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TLX1重组蛋白
  • 货号：
    CSB-BP023609HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TLX1重组蛋白
  • 货号：
    CSB-MP023609HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TLX1
  • Uniprot No.：
  • 别名：
    Homeo box 11 (T cell leukemia 3 associated breakpoint homologous to Drosophila Notch); Homeo box 11 (T cell lymphoma 3 associated breakpoint); Homeobox 11; Homeobox protein Hox 11; Homeobox protein Hox-11; Homeobox TLX-1; Hox-11; Hox11; MGC163402; OTTHUMP00000020816; Proto oncogene TCL 3; Proto-oncogene TCL-3; RGD1563655; T cell leukemia homeobox protein 1; T cell leukemia lymphoma protein 3; T-all, included; T-cell acute lymphocytic leukemia, included; T-cell leukemia 3 gene; T-cell leukemia homeobox protein 1; T-cell leukemia, homeobox 1; T-cell leukemia/lymphoma protein 3; TCL 3 proto oncogene; TCL3; Tlx-1; TLX1; TLX1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-330
  • 氨基酸序列
    MEHLGPHHLH PGHAEPISFG IDQILNSPDQ GGCMGPASRL QDGEYGLGCL VGGAYTYGGG GSAAATGAGG AGAYGTGGPG GPGGPAGGGG ACSMGPLTGS YNVNMALAGG PGPGGGGGSS GGAGALSAAG VIRVPAHRPL AGAVAHPQPL ATGLPTVPSV PAMPGVNNLT GLTFPWMESN RRYTKDRFTG HPYQNRTPPK KKKPRTSFTR LQICELEKRF HRQKYLASAE RAALAKALKM TDAQVKTWFQ NRRTKWRRQT AEEREAERQQ ANRILLQLQQ EAFQKSLAQP LPADPLCVHN SSLFALQNLQ PWSDDSTKIT SVTSVASACE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.
  • 基因功能参考文献：
    1. TLX1 hypermethylation is associated with colorectal cancer. PMID: 28351398
    2. The occurrence of G-quadruplex structures at the HOX11 breakpoint region explain its fragility during the t(10;14) translocation. PMID: 24001773
    3. these results place TLX1 and TLX3 at the top of an oncogenic transcriptional network controlling leukemia development, and identify RUNX1 as a tumor-suppressor gene in T-ALL PMID: 22366949
    4. The cortical thymic maturation arrest in T-lineage Acute lymphoblastic leukemias (ALLs) that overexpress TLX1 or TLX3 is due to binding of TLX1/TLX3 to ETS1. PMID: 22516263
    5. Suppression of TLX1 expression slowed the growth of TLX1 tumor cell lines. Suppression of TLX1 in vivo also transiently delayed leukemia progression. PMID: 21326611
    6. conclude that the TLX1/NOTCH/MYC network is a central determinant promoting the growth and survival of TLX1+ T-ALL cells. In addition, the TLX1/NOTCH/MYC transcriptional network coregulates genes involved in T cell development PMID: 20618946
    7. Transgenic expression of human TLX1 in mice induces T cell acute lymphoblastic leukemia with frequent deletions and mutations in Bcl11b. PMID: 20972433
    8. co-operation between TLX1 and MEIS proteins may have a significant role in T-cell leukemogenesis. PMID: 19559479
    9. A PBX2 Regulatory Element PRE-1048 has been identified which contains a novel DNA-binding sequence and mediates significant activation of the HOX11 gene in K562 cells. PMID: 12054735
    10. Seven conserved Cdx binding sites were found in the Hoxa 11 promoter, suggesting regulatory sites. PMID: 12180349
    11. Hox11 expression is linked to chromosomes 5 and 14 in T-cell malignancies in children. PMID: 14504110
    12. HOX11 manifests its regulatory function via its action as a transcription factor PMID: 15384172
    13. transcriptional deregulation of G1/S growth-control genes, mediated in large part through blockade of PP1/PP2A phosphatase activity, plays an important role in HOX11 pathobiology PMID: 15897879
    14. HOX11 overexpression leads to a heightened predisposition for development of aneuploidy, contributing to oncogenesis PMID: 16407851
    15. TLX1/HOX11 overexpression and Ubr1 inactivation in promoting chromosome missegregation, permitting the accrual of additional chromosome losses and cytogenic abnormalities en route to malignancy. PMID: 16862188
    16. TLX1-mediated differentiation arrest may be achieved in part through a mechanism that involves redirection of CBP and/or its sequestration in repressive chromatin domains PMID: 17213805
    17. TLX1(+) T-cell acute lymphoblastic leukemias be defined as cases expressing TLX1/ABL ratios greater than 1 and/or demonstrating TLX1 rearrangement PMID: 17609427
    18. Hox11 is expressed in spleen and may have a role in acute lymphocytic leukemia PMID: 17713543
    19. These results characterize TLX1 as a dual function regulator whose activity in respect to FHL1 is critically dependent upon its cellular concentration, as well as cell type and promoter context. PMID: 18073142
    20. LMO2, TAL1, Ttg-1, and SIL support levels of V(D)J recombination above background levels in cell culture and are also cleaved by the RAG proteins, while Hox11 and SCL are nicked but not cleaved efficiently in vitro PMID: 18187418
    21. Application of expression of HOX 11 allows the prospective evaluation of prognostic effects within pediatric and adult protocols of patients with T cell lymphoblastic lymphoma. PMID: 18245528
    22. HOX11/TLX1 stem cells are uniquely and abundantly expressed throughout adulthood in the human spleen. PMID: 18283632
    23. Aberrant HOX11 expression is associated with thymic adult T-cell acute lymphoblastic leukemia PMID: 18368072
    24. TLX1 interacts with TLE1 via an Eh1-like motif. PMID: 19250647

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  • 相关疾病：
    A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD.
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 5056

    OMIM: 186770

    KEGG: hsa:3195

    STRING: 9606.ENSP00000359215

    UniGene: Hs.89583