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  4. Recombinant Human T-cell leukemia homeobox protein 3 (TLX3)

Recombinant Human T-cell leukemia homeobox protein 3 (TLX3)

  • 货号：
    CSB-YP023611HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023611HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP023611HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023611HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023611HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TLX3
  • Uniprot No.：
  • 别名：
    homeo box 11-like 2; Homeobox protein Hox 11L2; Homeobox protein Hox-11L2; HOX11 L2; HOX11L2; RNX; T cell leukemia homeobox 3; T cell leukemia homeobox protein 3; T-cell leukemia homeobox protein 3; TLX 3; TLX3; TLX3_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-291
  • 氨基酸序列
    MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG RPGATYPSLP ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV PPPLPSALPA MPSVPTVSSL GGLNFPWMES SRRFVKDRFT AAAALTPFTV TRRIGHPYQN RTPPKRKKPR TSFSRVQICE LEKRFHRQKY LASAERAALA KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM LQLQHDAFQK SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Egyptian T-cell acute lymphoblastic leukemia cases seemed to have a different genetic pattern compared to other populations, with a lower incidence of TLX3/HOX11L2 and SIL/TAL but a higher incidence of NKX2-5 expression than recorded in Western countries PMID: 24571118
    2. Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia. PMID: 26852660
    3. Studies suggest that homeobox protein TLX3 expression is not an indicator for the prognosis of pediatric T cell acute lymphocytic leukemia (T-ALL). PMID: 24997618
    4. these results place TLX1 and TLX3 at the top of an oncogenic transcriptional network controlling leukemia development, and identify RUNX1 as a tumor-suppressor gene in T-ALL PMID: 22366949
    5. The cortical thymic maturation arrest in T-lineage Acute lymphoblastic leukemias (ALLs) that overexpress TLX1 or TLX3 is due to binding of TLX1/TLX3 to ETS1. PMID: 22516263
    6. We found that 22 (21%) out of 110 clinical samples of bladder cancer showed the methylated pattern using the COBRA assay in TLX3. We found a correlation between TLX3 methylation and the sensitivity to cisplatin in the clinical samples by SDI test. PMID: 21617853
    7. Results identify Tlx3 as a novel target for canonical Wnt signaling that confers somatic stem cells with a sensory neuron phenotype upon neural induction. PMID: 21374761
    8. High TLX3/BCL11B fusion protein expression is associated with T/myeloid acute bilineal leukemia. PMID: 21225930
    9. HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis. PMID: 12130513
    10. s conclude that RNX, and presumably its expression, are not altered in the index cases of congenital central hypoventilation syndrome. PMID: 12407709
    11. High incidence of Hox11L2 expression in children with T-ALL PMID: 12454747
    12. Translocations in Hox11L2 locus is associated with T-cell acute lymphoblastic leukemia PMID: 12970786
    13. HOX11L2 expression is linked to chromosomes 5 and 14 in T-cell malignancies in children. PMID: 14504110
    14. TLX3 expression in T-ALL is strongly associated with the presence of genomic rearrangements PMID: 15334547
    15. The TLX3 protein is high levels expressed in the leukemia cells in keeping with the presence of t(5;14)(q35;q14) in leukemia cells. PMID: 15674415
    16. The Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols. PMID: 15990867
    17. The present report is focused on the identification of elements and factors playing a role in the TLX3 physiologic expression regulation and therefore likely to be involved in cancer development. PMID: 16966433
    18. In T-cell acute lymphoblastic leukemia, alternative t(5;14)(q35;q32.2) forms effect dysregulation of either TLX3 or NKX2-5 homeobox genes at 5q35 by juxtaposition with 14q32.2 breakpoints dispersed across the BCL11B downstream genomic desert. PMID: 17308084
    19. five recurrent genomic deletions in TLX3 rearranged T-ALL; genome-wide overview of copy number changes in TLX3 rearranged T-ALL PMID: 18185524
    20. Aberrant HOX11L2 expression is associated with thymic adult T-cell acute lymphoblastic leukemia PMID: 18368072

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 13532

    OMIM: 604640

    KEGG: hsa:30012

    STRING: 9606.ENSP00000296921

    UniGene: Hs.249125