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  4. Recombinant Human T-cell leukemia virus 1 Accessory protein p30II

Recombinant Human T-cell leukemia virus 1 Accessory protein p30II

  • 货号：
    CSB-YP313863HQJ
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP313863HQJ
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP313863HQJ-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP313863HQJ
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP313863HQJ
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 别名：
    Accessory protein p30II
  • 种属：
    Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-241
  • 氨基酸序列
    MALCCFAFSA PCLHLRSRRS CSSCFLLATS AAFFSARLLR RAFSSSFLFK YSAVCFSSSF SRSFFRFLFS SARRCRSRCV SPRGGAFSPG GPRRSRPRLS SSKDSKPSST ASSSSLSFNS SSKDNSPSTN SSTSRSSGHD TGKHRNSPAD TKLTMLIISP LPRVWTESSF RIPSLRVWRL CTRRLVPHLW GTMFGPPTSS RPTGHLSRAS DHLGPHRWTR YRLSSTVPYP STPLLPHPEN L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    p30II is a multifunctional regulator that sequesters EP300/CREBBP and down-regulates CREB-responsive element (CRE) and Tax-responsive element (TRE) mediated transcription. Specifically binds and represses tax/rex mRNA nuclear export. Since Tax and Rex are positive regulators of viral gene expression, their inhibition by p30II reduces virion production, and allows the virus to escape the host immune surveillance and persist latently in an immune-competent host.; p13II increases mitochondrial permeability to monovalent cations, producing a rapid, membrane potential-dependent influx of potassium. This could involve a channel-forming activity. Interferes with cell proliferation and transformation and promotes apoptosis induced by ceramide and Fas ligand, probably using the Ras signaling.
  • 亚细胞定位：
    [Isoform p30II]: Host nucleus, host nucleolus.; [Isoform p13II]: Host mitochondrion inner membrane.
  • 蛋白家族：
    HTLV-1 accessory protein p30II family