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  4. Recombinant Human T-cell leukemia virus 1 Envelope glycoprotein gp62 (env), partial

Recombinant Human T-cell leukemia virus 1 Envelope glycoprotein gp62 (env), partial

  • 货号：
    CSB-YP319642HQG
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP319642HQG
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP319642HQG-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP319642HQG
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP319642HQG
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    env
  • Uniprot No.：
  • 别名：
    envEnvelope glycoprotein gp62; Env polyprotein) [Cleaved into: Surface protein; SU; Glycoprotein 46; gp46); Transmembrane protein; TM; Glycoprotein 21; gp21)]
  • 种属：
    Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The surface protein (SU) attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane.; The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
  • 基因功能参考文献：
    1. Taken together, separate intracellular localizations of GLUT1 and HTLV-1 Env are required for the fusion activity and infectivity of HTLV-1 Env. PMID: 25339765
    2. These results indicate that SU domain independently influences the preferential T cell immortalization tropism irrespective of the envelope counterpart transmembrane (TM) domain. PMID: 23785214
    3. gp46 expression was highest in the anaplastic large cell type, followed by the pleomorphic type and Hodgkin's-like type PMID: 21091835
    4. hDlg stabilizes HTLV-1 envelope glycoproteins at the virological synapse formed between infected and target cells, hence assisting the cell-to-cell transmission of the virus PMID: 15286176
    5. sequence of the entire env gene of 65 HTLV-I isolates originating from Gabon, French Guiana, West Indies, and Iran PMID: 15665642
    6. investigated the functional role of the glycine-rich segment, Met-326 to Ser-337; fusion function appears to require flexibility within the glycine-rich segment and hydrophobic contacts mediated by this segment PMID: 15767455
    7. distinct domains of the glucose transporter GLUT1 mediate HTLV envelope binding and virus entry PMID: 15955807
    8. The study finds that the fusion activity of HTLV-1 Env is controlled by an SU CXXC-mediated isomerization of the intersubunit disulfide. PMID: 18480461

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  • 亚细胞定位：
    [Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.; [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein.
  • 数据库链接：

    KEGG: vg:1491939