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  4. Recombinant Human T-cell leukemia virus 1 Gag polyprotein (gag), partial

Recombinant Human T-cell leukemia virus 1 Gag polyprotein (gag), partial

  • 货号：
    CSB-YP321199HQG1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP321199HQG1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP321199HQG1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP321199HQG1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP321199HQG1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    gag; Gag polyprotein; Pr53Gag) [Cleaved into: Matrix protein p19; MA); Capsid protein p24; CA); Nucleocapsid protein p15-gag; NC-gag)]
  • 种属：
    Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The matrix domain targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus.; Matrix protein.; Forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.; Binds strongly to viral nucleic acids and promote their aggregation. Also destabilizes the nucleic acids duplexes via highly structured zinc-binding motifs.
  • 基因功能参考文献：
    1. Altogether, these data suggest that Gag targeting and membrane binding mediated by HTLV-1 matrix domain does not require phosphatidylinositol-(4,5)-bisphosphate and that distinct mechanisms regulate HIV-1 and HTLV-1 Gag membrane binding. PMID: 21289126
    2. Nedd4.1 and Tsg101 act successively in the assembly process of HTLV-1 to ensure proper Gag trafficking through the endocytic pathway up to late endosomes where the late steps of retroviral release occur PMID: 15126635
    3. beta-hairpin contributes to overall structure of mature capsid protein; differences in the backbone dynamics of the beta-hairpin contribute to mature capsid structure, possibly introducing flexibility into interface formation during proteolytic maturation PMID: 15569685
    4. findings have shown that HTLV-1 Gag associates with CD82-enriched plasma membrane microdomains in Jurkat T cells PMID: 16325219
    5. HTLV-1 gag proviral sequences were revealed in two cases of lymphoproliferative disorders such as angiolymphoid hyperplasia with eosinophilia (ALHE) and CD4+ cutaneous lymphoma, respectively. PMID: 16400878
    6. data show that the HTLV-1 matrix protein may be phosphorylated by cellular ERK-2 kinase and indicate that phosphorylation of L-domain-containing proteins may be a common post-translational modification required for appropriate retroviruses budding PMID: 16635502

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  • 亚细胞定位：
    [Matrix protein p19]: Virion.; [Capsid protein p24]: Virion.; [Nucleocapsid protein p15-gag]: Virion.
  • 数据库链接：

    KEGG: vg:1491934