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  4. Recombinant Human TANK-binding kinase 1-binding protein 1 (TBKBP1)

Recombinant Human TANK-binding kinase 1-binding protein 1 (TBKBP1)

  • 货号：
    CSB-YP023233HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023233HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP023233HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023233HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023233HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    KIAA0775; ProSAPiP2; SINTBAD; TANK binding kinase 1 binding protein 1; TANK-binding kinase 1-binding protein 1; TBK1 binding protein 1; TBK1-binding protein 1; TBKB1_HUMAN; Tbkbp1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-615
  • 氨基酸序列
    MESMFEDDIS ILTQEALGPS EVWLDSPGDP SLGGDMCSAS HFALITAYGD IKERLGGLER ENATLRRRLK VYEIKYPLIS DFGEEHGFSL YEIKDGSLLE VEKVSLQQRL NQFQHELQKN KEQEEQLGEM IQAYEKLCVE KSDLETELRE MRALVETHLR QICGLEQQLR QQQGLQDAAF SNLSPPPAPA PPCTDLDLHY LALRGGSGLS HAGWPGSTPS VSDLERRRLE EALEAAQGEA RGAQLREEQL QAECERLQGE LKQLQETRAQ DLASNQSERD MAWVKRVGDD QVNLALAYTE LTEELGRLRE LSSLQGRILR TLLQEQARSG GQRHSPLSQR HSPAPQCPSP SPPARAAPPC PPCQSPVPQR RSPVPPCPSP QQRRSPASPS CPSPVPQRRS PVPPSCQSPS PQRRSPVPPS CPAPQPRPPP PPPPGERTLA ERAYAKPPSH HVKAGFQGRR SYSELAEGAA YAGASPPWLQ AEAATLPKPR AYGSELYGPG RPLSPRRAFE GIRLRFEKQP SEEDEWAVPT SPPSPEVGTI RCASFCAGFP IPESPAATAY AHAEHAQSWP SINLLMETVG SDIRSCPLCQ LGFPVGYPDD ALIKHIDSHL ENSKI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.
  • 基因功能参考文献：
    1. The two selected single nucleotide polymorphisms (SNPs) in TBKBP1 show no relationship with the clinical outcomes. None of the 12 SNPs is related to mSASSS. PMID: 25494292
    2. TBKBP1 is associated with the severity of ankylosing spondylitis in the Chinese Han population PMID: 23637848
    3. Studies show that three proteins expressed in HEK-293T cells (NAP1, TANK and TBKBP1) interact with TBK1. PMID: 23286385
    4. results suggest that efficient signal transduction upon viral infection requires SINTBAD, TANK and NAP1 because they link TBK1 and IKKi to virus-activated signalling cascades PMID: 17568778
  • 组织特异性：
    Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus.
  • 数据库链接：

    HGNC: 30140

    OMIM: 608476

    KEGG: hsa:9755

    STRING: 9606.ENSP00000354777

    UniGene: Hs.94790