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  4. Recombinant Human Tachykinin-4 (TAC4)

Recombinant Human Tachykinin-4 (TAC4)

  • 货号：
    CSB-YP771439HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP771439HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP771439HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP771439HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP771439HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TAC4
  • Uniprot No.：
  • 别名：
    TAC4; Tachykinin-4; Preprotachykinin-C; PPT-C) [Cleaved into: Endokinin-A; EKA); Endokinin-A/B; EKA/B); Endokinin-C; EKC)]
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    21-67
  • 氨基酸序列
    DGGEEQTLST EAETWVIVAL EEGAGPSIQL QLQEVKTGKA SQFFGLM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.
  • 基因功能参考文献：
    1. Kinase activation led to increased MMP-2 and MT1-MMP expression and melanoma cell migration induced by hHK-1. Thus, hHK-1 and the NK1 receptor are critical to melanoma cell migration and each may be a promising chemotherapeutic target PMID: 27458061
    2. expressed in mural granulosa and cumulus cells PMID: 27146034
    3. Expression substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors are dysregulated in uterine leiomyomata. PMID: 27456549
    4. HKs emerge as pivotal endogenous regulators of angiogenesis through neurokinin-1 receptor PMID: 22554585
    5. Data provide evidence for the first time that hemokinin-1, like substance P, may be involved in the pathophysiology of inflammatory bowel disease. PMID: 21342363
    6. HK-1 and substance P are novel T helper (Th)17 cell-inducing factors that may act locally on memory T cells to amplify inflammatory responses. PMID: 21368235
    7. Endogenous expression of hemokinin-1 is demonstrated in bronchi and is involved in contraction of airway explants. PMID: 20929541
    8. hHK-1 and its C-terminal fragments are human NK1 receptor agonists with different functional selectivity properties and that such functional selectivity leads to differential activation of downstream signaling and receptor trafficking. PMID: 21168392
    9. A possible association is found between a tachykinin-4 single nucleotide polymorphism and susceptibility to asthma. PMID: 20580442
    10. Observational study of gene-disease association. (HuGE Navigator) PMID: 20580442
    11. Results suggest that Hemokinin-1 is regulated by a unique transcription regulation system that likely governs its differential expression pattern and suggests a role for Hemokinin-1 distinct from Substance P. PMID: 19081134
    12. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 17175032

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Tachykinin family
  • 组织特异性：
    Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are e
  • 数据库链接：

    HGNC: 16641

    OMIM: 607833

    KEGG: hsa:255061

    STRING: 9606.ENSP00000334042

    UniGene: Hs.652130