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  4. Recombinant Human Taste receptor type 2 member 4 (TAS2R4), partial

Recombinant Human Taste receptor type 2 member 4 (TAS2R4), partial

  • 中文名称：
    人TAS2R4重组蛋白
  • 货号：
    CSB-YP882148HU1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TAS2R4重组蛋白
  • 货号：
    CSB-EP882148HU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TAS2R4重组蛋白
  • 货号：
    CSB-EP882148HU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TAS2R4重组蛋白
  • 货号：
    CSB-BP882148HU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TAS2R4重组蛋白
  • 货号：
    CSB-MP882148HU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    TAS2R4; Taste receptor type 2 member 4; T2R4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.
  • 基因功能参考文献：
    1. demonstrate that Lys117, an important CRAC residue, is crucial in the reported cholesterol sensitivity of T2R4. Interestingly, cholesterol sensitivity of T2R4 was observed at quinine concentrations in the lower mM range. PMID: 27288892
    2. This study is the first to show an inhibitory downstream action of a T2R4 agonist on Rac1 function. PMID: 27873143
    3. Data indicate that KLK/R motif in C-terminus performs functional role in bitter taste receptor T2R4 signaling. PMID: 25858111
    4. The antagonist ability of ABA was tested using another T2R4 agonist, yohimbine. Our results suggest that ABA does not inhibit yohimbine-induced T2R4 activity. PMID: 25844797
    5. Data indicate that the itter blockers and agonists share the same orthosteric site in bitter taste receptor T2R4. PMID: 25059668
    6. these results show that rhodopsin N-terminal 33 amino acids enhance expression of T2R4 by 2.5-fold and do not cause perturbations in the receptor structure. PMID: 23159609
    7. This study demonistrated that human TAS2R4 play the role of food preference behavior. PMID: 22794107

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia.
  • 蛋白家族：
    G-protein coupled receptor T2R family
  • 组织特异性：
    Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed on airway ciliated epithelium.
  • 数据库链接：

    HGNC: 14911

    OMIM: 604869

    KEGG: hsa:50832

    STRING: 9606.ENSP00000247881

    UniGene: Hs.735690