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  4. Recombinant Human Testosterone 17-beta-dehydrogenase 3 (HSD17B3)

Recombinant Human Testosterone 17-beta-dehydrogenase 3 (HSD17B3)

  • 中文名称：
    人HSD17B3重组蛋白
  • 货号：
    CSB-YP010773HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HSD17B3重组蛋白
  • 货号：
    CSB-EP010773HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HSD17B3重组蛋白
  • 货号：
    CSB-EP010773HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HSD17B3重组蛋白
  • 货号：
    CSB-BP010773HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HSD17B3重组蛋白
  • 货号：
    CSB-MP010773HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HSD17B3
  • Uniprot No.：
  • 别名：
    17 @beta HSD III; 17 beta HSD 3; 17-@beta hydroxysteroid dehydrogenase III; 17-beta-HSD 3; 17-beta-hydroxysteroid dehydrogenase type 3; DHB3_HUMAN; EC 1.1.1.64; EDH17B3; Estradiol 17 beta dehydrogenase ; Estradiol 17 beta dehydrogenase 3; HSD17B3; Hydroxysteroid (17 beta) dehydrogenase 3; OTTHUMP00000021718; SDR12C2; Short chain dehydrogenase/reductase family 12C member 2; Testicular 17 @beta hydroxysteroid dehydrogenase III; Testicular 17 beta hydroxysteroid dehydrogenase ; Testicular 17-beta-hydroxysteroid dehydrogenase; Testosterone 17 beta dehydrogenase 3; Testosterone 17-beta-dehydrogenase 3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-310
  • 氨基酸序列
    MGDVLEQFFI LTGLLVCLAC LAKCVRFSRC VLLNYWKVLP KSFLRSMGQW AVITGAGDGI GKAYSFELAK RGLNVVLISR TLEKLEAIAT EIERTTGRSV KIIQADFTKD DIYEHIKEKL AGLEIGILVN NVGMLPNLLP SHFLNAPDEI QSLIHCNITS VVKMTQLILK HMESRQKGLI LNISSGIALF PWPLYSMYSA SKAFVCAFSK ALQEEYKAKE VIIQVLTPYA VSTAMTKYLN TNVITKTADE FVKESLNYVT IGGETCGCLA HEILAGFLSL IPAWAFYSGA FQRLLLTHYV AYLKLNTKVR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms.
  • 基因功能参考文献：
    1. mutations of HSD17B3 in three Chinese patients with 46,XY Disorders of Sex Development PMID: 28774765
    2. The 17beta-HSD3 G289S substitution, previously reported in other patients with 46,XY disorders of sex development, is a polymorphism that does not cause the disorder. PMID: 28859874
    3. The study shows that 17-beta-HSD-3 deficiency is not an uncommon disorder among Egyptian DSD cases. It was evidenced that the mutational profile of the disease is rather heterogeneous, relatively different from those reported in other populations, and has a high degree of novel genetic defects. PMID: 27073926
    4. analysis of Tunisian patients with mutations in the gene encoding 17beta-hydroxysteroid dehydrogenase type 3 and a founder effect PMID: 26956191
    5. Mutation G133R in HSD17B3 results in almost complete loss of enzyme activity since it interferes with binding of cofactor NADPH. PMID: 26545797
    6. Mutations in the HSD17B3 gene is associated with Disorders of Sex Development. PMID: 25879310
    7. Missense mutation in HSD17B3 gene in a 46, XY adolescent is associated with primary amenorrhea and virilization at puberty PMID: 25064799
    8. 38% of unrelated 46,XY females with unknown diagnosis in the study have HSD17B3 mutations predicted to cause HSD17B3 deficiency. PMID: 25740850
    9. These results suggest that the HSD17B3 G289S polymorphism may be a potential risk modifier for hypospadias. PMID: 20059664
    10. 68 males with testicular 17beta-HSD deficiency were identified among a highly inbred Arab population in Israel as affected with male pseudohermaphroditism. [Review] PMID: 22217844
    11. The H8 haplotype of the HSD17B3 gene was significantly associated with increased risks of acne vulgaris in Han Chinese from the Southwest China. PMID: 24157973
    12. Case Report: rare form of 46,XY disorders of sexual development, associated to a novel gene nonsense mutation of HSD17B3 gene. PMID: 22594312
    13. Circulating testosterone levels were higher in men with early repolarization electrocardiograms. PMID: 23916922
    14. Androgen-metaboliizing enzymes, 17betaHSD5 and 5alpha1 immunoreactivity was decreased in metastatic lymph nodes of breast cancers. PMID: 23953348
    15. in two sisters with 17beta hydroxysteroid dehydrogenase type 3 deficiency, a heterozygous mutation for both a known splicing mutation and a previously unreported amplification mutation of the HSD17B3 gene were identified PMID: 23375913
    16. Results demonstrate a cytoplasmic orientation of 17beta-HSD3 and dependence on glucose-6-phosphate dehydrogenase-generated NADPH, explaining the lack of a direct functional coupling with the luminal 11beta-HSD1-mediated glucocorticoid metabolism PMID: 23183177
    17. oxazolidinediones and thiazolidinediones are potent 17beta-hydroxysteroid dehydrogenase type 3 inhibitors PMID: 22137341
    18. XY sex reversal is sufficiently variable in 17betaHSD3 deficiency to cause problems in accurate diagnosis, particularly in distinguishing it from Androgen Insentitivity Syndrome in undervirilized males.. PMID: 17466011
    19. present the clinical, biochemical, and genetic features of a male pseudohermaphrodite whose condition was caused by 17beta-HSD3 deficiency. PMID: 17509588

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  • 相关疾病：
    Male pseudohermaphrodism with gynecomastia (MPH)
  • 亚细胞定位：
    Endoplasmic reticulum.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family, 17-beta-HSD 3 subfamily
  • 组织特异性：
    Testis.
  • 数据库链接：

    HGNC: 5212

    OMIM: 264300

    KEGG: hsa:3293

    STRING: 9606.ENSP00000364412

    UniGene: Hs.477