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  4. Recombinant Human Tetraspanin-2 (TSPAN2), partial

Recombinant Human Tetraspanin-2 (TSPAN2), partial

  • 中文名称：
    人TSPAN2重组蛋白
  • 货号：
    CSB-EP025157HU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TSPAN2重组蛋白
  • 货号：
    CSB-EP025157HU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TSPAN2重组蛋白
  • 货号：
    CSB-BP025157HU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TSPAN2重组蛋白
  • 货号：
    CSB-MP025157HU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Name:TSPAN2
  • Uniprot No.：
  • 别名：
    TSPAN2; Tetraspanin-2; Tspan-2; Tetraspan NET-3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.
  • 基因功能参考文献：
    1. the s have identified TSPAN2 as a candidate gene for Blood Pressure Regulation that is regulated by heritable DNA methylation PMID: 29198723
    2. TSPAN2 may promote apoptosis of RNAKT-15 cells by regulating the JNK/beta-catenin pathway in response to high glucose concentrations. Targeting TSPAN2 could be a potential therapeutic strategy to treat glucose toxicity-induced beta-cell failure. PMID: 27247127
    3. A novel locus (G allele at rs12122341) at 1p13.2 near TSPAN2 that was associated with large artery atherosclerosis-related stroke. PMID: 26708676
    4. Studies suggest that TSPAN2 may contribute to the early stages of the oligodendrocyte differentiation into myelin-forming glia. Furthermore, in human lung cancer, Tspan2 could be involved in the progression of the tumour metastasis by modulating cancer cell motility and invasion functions. [review] PMID: 28408487
    5. TSPAN2 is identified as a factor responsible for invasion, motility, and metastasis. PMID: 24726368
    6. the C-allele of rs2078371 near TSPAN-2 also reached genome-wide significance for association with migraine. PMID: 23294458

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Tetraspanin (TM4SF) family
  • 数据库链接：

    HGNC: 20659

    OMIM: 613133

    KEGG: hsa:10100

    STRING: 9606.ENSP00000358529

    UniGene: Hs.310458