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  4. Recombinant Human Thioredoxin domain-containing protein 3 (TXNDC3)

Recombinant Human Thioredoxin domain-containing protein 3 (TXNDC3)

  • 货号：
    CSB-YP843151HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP843151HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP843151HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP843151HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP843151HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NME8
  • Uniprot No.：
  • 别名：
    NME8; SPTRX2; TXNDC3; Thioredoxin domain-containing protein 3; NM23-H8; NME/NM23 family member 8; Spermatid-specific thioredoxin-2; Sptrx-2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-588
  • 氨基酸序列
    MASKKREVQL QTVINNQSLW DEMLQNKGLT VIDVYQAWCG PCRAMQPLFR KLKNELNEDE ILHFAVAEAD NIVTLQPFRD KCEPVFLFSV NGKIIEKIQG ANAPLVNKKV INLIDEERKI AAGEMARPQY PEIPLVDSDS EVSEESPCES VQELYSIAII KPDAVISKKV LEIKRKITKA GFIIEAEHKT VLTEEQVVNF YSRIADQCDF EEFVSFMTSG LSYILVVSQG SKHNPPSEET EPQTDTEPNE RSEDQPEVEA QVTPGMMKNK QDSLQEYLER QHLAQLCDIE EDAANVAKFM DAFFPDFKKM KSMKLEKTLA LLRPNLFHER KDDVLRIIKD EDFKILEQRQ VVLSEKEAQA LCKEYENEDY FNKLIENMTS GPSLALVLLR DNGLQYWKQL LGPRTVEEAI EYFPESLCAQ FAMDSLPVNQ LYGSDSLETA EREIQHFFPL QSTLGLIKPH ATSEQREQIL KIVKEAGFDL TQVKKMFLTP EQIEKIYPKV TGKDFYKDLL EMLSVGPSMV MILTKWNAVA EWRRLMGPTD PEEAKLLSPD SIRAQFGISK LKNIVHGASN AYEAKEVVNR LFEDPEEN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.
  • 基因功能参考文献：
    1. Studies suggest that the rs2718058 near gene NME8 on chromosome 7p14.1 might not play a major role in the genetic predisposition to late-onset Alzheimer's disease (LOAD) in the North Han Chinese. PMID: 27144521
    2. Addition of the minor allele for rs670139 (MS4A4E), rs9331896 (CLU), and rs12155159 (NME8) was nominally associated with change on the DWRT, DSST, and WFT, respectively, in whites. PMID: 27781389
    3. NME8 locus polymorphism is associated with cognitive decline, cerebrospinal fluid and neuroimaging biomarkers in Alzheimer's disease. PMID: 25486118
    4. GPR141-NME8 locus had strong genetic effect on the susceptibility to generalized periodontitis in Japanese individuals with history of smoking. identified 2 suggestive loci for periodontitis in a Japanese population. PMID: 25672891
    5. Our approach yielded 26 candidate genes differentially expressed between patients (Osteoarthritis) and controls. The presence of allelic imbalances confirms cis-regulatory mechanisms for RHOB and TXNDC3. PMID: 16642435
    6. genetic association of RHOB and TXNDC3 with osteoarthritis was detected PMID: 17304710
    7. Primary ciliary dyskinesia is caused by an SNP-induced modification of the ratio of two physiological isoforms of TXNDC3 generated by alternative splicing. PMID: 17360648
    8. The minor allele frequencies of TXNDC3 in East Asian individuals are significantly different from those in United Kingdom control individuals. PMID: 18471322

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  • 相关疾病：
    Ciliary dyskinesia, primary, 6 (CILD6)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    NDK family
  • 组织特异性：
    Testis-specific. Expressed only in primary spermatocytes and round spermatids.
  • 数据库链接：

    HGNC: 16473

    OMIM: 607421

    KEGG: hsa:51314

    STRING: 9606.ENSP00000199447

    UniGene: Hs.723454