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NME8 Antibody

  • 中文名称：
    NME8兔多克隆抗体
  • 货号：
    CSB-PA109162
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA109162(NME8 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q8N427
  • 基因名：
    NME8
  • 别名：
    NME8 antibody; SPTRX2 antibody; TXNDC3 antibody; Thioredoxin domain-containing protein 3 antibody; NM23-H8 antibody; NME/NM23 family member 8 antibody; Spermatid-specific thioredoxin-2 antibody; Sptrx-2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human NME8
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:30-1:150
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.
  • 基因功能参考文献：
    1. Studies suggest that the rs2718058 near gene NME8 on chromosome 7p14.1 might not play a major role in the genetic predisposition to late-onset Alzheimer's disease (LOAD) in the North Han Chinese. PMID: 27144521
    2. Addition of the minor allele for rs670139 (MS4A4E), rs9331896 (CLU), and rs12155159 (NME8) was nominally associated with change on the DWRT, DSST, and WFT, respectively, in whites. PMID: 27781389
    3. NME8 locus polymorphism is associated with cognitive decline, cerebrospinal fluid and neuroimaging biomarkers in Alzheimer's disease. PMID: 25486118
    4. GPR141-NME8 locus had strong genetic effect on the susceptibility to generalized periodontitis in Japanese individuals with history of smoking. identified 2 suggestive loci for periodontitis in a Japanese population. PMID: 25672891
    5. Our approach yielded 26 candidate genes differentially expressed between patients (Osteoarthritis) and controls. The presence of allelic imbalances confirms cis-regulatory mechanisms for RHOB and TXNDC3. PMID: 16642435
    6. genetic association of RHOB and TXNDC3 with osteoarthritis was detected PMID: 17304710
    7. Primary ciliary dyskinesia is caused by an SNP-induced modification of the ratio of two physiological isoforms of TXNDC3 generated by alternative splicing. PMID: 17360648
    8. The minor allele frequencies of TXNDC3 in East Asian individuals are significantly different from those in United Kingdom control individuals. PMID: 18471322

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  • 相关疾病：
    Ciliary dyskinesia, primary, 6 (CILD6)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    NDK family
  • 组织特异性：
    Testis-specific. Expressed only in primary spermatocytes and round spermatids.
  • 数据库链接：

    HGNC: 16473

    OMIM: 607421

    KEGG: hsa:51314

    STRING: 9606.ENSP00000199447

    UniGene: Hs.723454