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  4. Recombinant Human Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 (TSTD1)

Recombinant Human Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 (TSTD1)

  • 中文名称：
    人TSTD1重组蛋白
  • 货号：
    CSB-YP839875HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TSTD1重组蛋白
  • 货号：
    CSB-EP839875HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TSTD1重组蛋白
  • 货号：
    CSB-EP839875HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TSTD1重组蛋白
  • 货号：
    CSB-BP839875HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TSTD1重组蛋白
  • 货号：
    CSB-MP839875HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TSTD1
  • Uniprot No.：
  • 别名：
    KAT; Putative thiosulfate sulfurtransferase KAT; Thiosulfate sulfurtransferase (rhodanese) like domain containing 1; Thiosulfate sulfurtransferase KAT putative; Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1; TSTD1; TSTD1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-115
  • 氨基酸序列
    AGAPTVSLP ELRSLLASGR ARLFDVRSRE EAAAGTIPGA LNIPVSELES ALQMEPAAFQ ALYSAEKPKL EDEHLVFFCQ MGKRGLQATQ LARSLGYTGA RNYAGAYREW LEKES
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism. Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate. The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor.
  • 基因功能参考文献：
    1. Data suggest that TSTD1 can utilize thioredoxin as an acceptor in the presence of thioredoxin reductase and NADPH. PMID: 29348167
    2. Endurance exercise caused an increase in plasma KYNA within the first hour after exercise. In contrast, a bout of high-intensity eccentric exercise did not lead to increased plasma KYNA concentration. Our results show that regular endurance exercise causes adaptations in kynurenine metabolism which can have implications for exercise recommendations for patients with depressive disorder. PMID: 27030575
    3. Biosynthesis of a central intermediate in hydrogen sulfide metabolism by a novel human sulfurtransferase and its yeast ortholog. PMID: 24981631
    4. The presence of kynurenine aminotransferase III in Corpora amylacea in the human retina and optic nerve indicates that this enzyme may be relevant in mechanisms of neurodegeneration leading to Corpora amylaceaformation. PMID: 21845542
    5. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
    6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086

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  • 亚细胞定位：
    Cytoplasm, perinuclear region. Note=Localized around the nuclear membranes.
  • 组织特异性：
    Highly expressed in kidney, liver and skeletal muscle. Lower levels of expression in heart, colon, thymus, spleen, placenta and lung. Weakly expressed in brain, small intestine and peripheral blood leukocytes. Expressed at high levels in the breast carcin
  • 数据库链接：

    HGNC: 35410

    OMIM: 616041

    KEGG: hsa:100131187

    STRING: 9606.ENSP00000388293

    UniGene: Hs.720030