Recombinant Human Thrombopoietin (THPO)，partial

1. The expression of TPO and c-Mpl was significantly decreased in the cITP group compared to the nITP group, suggesting that TPO and its receptor may play important roles in childhood cITP pathogenesis. PMID: 29313460
2. FISH study showed no cytogenetic abnormalities in any of the analyzed cases. PMID: 16682284
3. results confirm that TPO acts as an acute phase protein but exclude the possibility that it is uniquely responsible for thrombocytosis of inflammatory disorders, which might recognize in IL-6 a credible candidate as a cooperating factor. PMID: 18041648
4. evidence for the presence of a low TPO gene expression transcript in B-CLL cells; early B-cell CLL circulating level of TPO does not provide a useful insight into the complex interrelationship of prognostic variables PMID: 18203013
5. Thrombopoietin levels are increased in patients with severe acute respiratory syndrome; TPO may have a role in thrombocytosis, which frequently develops from thrombocytopenia in SARS patients PMID: 18314161
6. separate binding sites on the Mpl receptor for TPO and hNUDC identified PMID: 20529857
7. Tensin2 is an important new mediator in TPO/c-Mpl pathway; Tensin2 becomes phosphorylated in a TPO dependent manner. PMID: 21527831
8. perioperative TPO dynamics are associated with postoperative LD. Postoperative TPO levels were found to be lowest in high-risk patients (HCC patients undergoing major resection) but showed an independent predictive value. PMID: 25611592
9. Data indicate thrombopoietin (TPO) as potential early prognostic biomarker in acute pancreatitis (AP) patients. PMID: 28079612
10. These studies demonstrate that biallelic loss-of-function mutations in THPO cause bone marrow failure, which is unresponsive to transplant due to a hematopoietic cell-extrinsic mechanism. PMID: 28559357
11. Genetically engineered mesenchymal stromal cells produce IL-3 and TPO to further improve human scaffold-based xenograft models PMID: 28456746
12. High Thrombopoietin expression is associated with immune thrombocytopenia in pregnancy. PMID: 26840092
13. Colorectal cancer tumor-initiating cells (TICs) expressing CD110, the thrombopoietin (TPO)-binding receptor, mediate liver metastasis. We show that TPO promotes metastasis of CD110+ TICs to the liver by activating lysine degradation. PMID: 26140605
14. decreased TPO levels or decreased bone marrow production of platelets may not be a cause of thrombocytopenia in chronic hepatitis C PMID: 25728497
15. WASP, RUNX1, and ANKRD26 genes are important for normal TPO signaling and the network underlying thrombopoiesis. PMID: 26175287
16. Data suggest that elevated serum level of thrombopoietin may serve as unfavorable marker of stage of multiple myeloma. PMID: 25323752
17. The regulation of OCs by TPO highlights a novel therapeutic target for bone loss diseases and may be important to consider in the numerous hematologic disorders associated with alterations in TPO/c-mpl signaling PMID: 25656774
18. TPO was greatly enhanced in HPT in comparison with ITP patients (958 +/- 659 and 11 +/- 27 pg/ml, p < 0.001). In the ITP group a reverse correlation was detected between TPO and glycocalicin (r = -0.373, p = 0.006). PMID: 25472766
19. observations suggest that NRP-1 is involved in megakaryocytopoiesis through complex formation with PDGFRs, and that NRP-1-PDGFR-complexes may contribute to effective cellular functions mediated by TPO and PDGF in megakaryocytic cells PMID: 25744030
20. An Arg->Cys substitution at residue 38 or residue 17 excluding the 21-AA signal peptide of the receptor binding domain was found in a family with aplastic anemia. Adding a 5th cysteine may disrupt normal disulfide bonding & receptor binding. PMID: 24085763
21. increased plasma thrombopoietin levels were associated with a favorable prognosis of bone marrow failure and could, therefore, represent a reliable marker for a benign subset of myelodysplastic syndrome. PMID: 23403320
22. Increased TPO levels may increase both platelet count and platelet size, resulting in more hemostatic tendency, which may contribute to the progression of ischemic stroke. PMID: 22327824
23. Platelet count and serum thrombopoietin level as predictors for morbidity and/or mortality in thrombocytopenic neonates. PMID: 22980223
24. Data indicate increased levels of serum thrombopoietin (TPO) were found in necrotizing pancreatitis. PMID: 22698803
25. Mutation in the THPO gene is not associated with aplastic anaemia in Japanese children. PMID: 22686250
26. Thrombopoietin is a biomarker and mediator of cardiovascular damage in critical diseases [review] PMID: 22577249
27. Findings establish that Clock regulates Thpo and Mpl expression in vivo, and demonstrate an important link between the body's circadian timing mechanisms and megakaryopoiesis. PMID: 22284746
28. Overstimulation of the THPO pathway might therefore predispose to clonal hematopoietic disease and to congenital abnormalities. PMID: 22453305
29. Data show that serum thrombopoietin levels in the affected family members were significantly higher than in the non-affected family members or healthy controls. PMID: 22194398
30. pattern of megakaryocytopoiesis is associated with up-regulated thrombopoietin (TPO) signaling through mammalian target of rapamycin (mTOR) and elevated levels of full-length GATA-1 and its targets PMID: 21304100
31. Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. PMID: 21262827
32. Findings thus suggest that decreased thrombopoietin production accompanying liver dysfunction may be related to thrombocytopenia besides myelosuppression in anorexia nervosa with malnutrition. PMID: 19810087
33. TPO negatively modulates cardiac inotropy in vitro and contributes to the myocardial depressing activity of septic shock serum PMID: 20467749
34. Overexpreeeion of human thrombopoietin increased the platelet level in the transfected mice. PMID: 11877062
35. Mutations in the 5' untranslated region of the TPO gene are not the cause of the normal or elevated TPO levels in acquired essential thrombocythemia. PMID: 11860444
36. REVIEW: central role in the pathogenesis of idiopathic thrombocytopenic purpura (ITP), andother immune-mediated thrombocytopenias. PMID: 11913997
37. While there is increased platelet turnover in patients with chronic renal failure, the kidney does not seem to play a major role in the overall Tpo production in the body. PMID: 11960394
38. binding to platelet thrombopoietin receptor is directly involved in human thrombopoietin plasma level regulation PMID: 11961237
39. Flt3/Flk-2-ligand in synergy with thrombopoietin may slow down megakaryocyte development by causing increased proliferation of megakaryocyte progenitor cells. PMID: 11983110
40. In the presence of EPO and SCF and/or IL-3, TPO enhances bone marrow erythropoiesis in cell cultures derived from patients with Diamond-Blackfan anemia. PMID: 12041668
41. Thrombopoietin activates MAPKp42/44, AKT, and STAT proteins in normal human CD34+ cells, megakaryocytes, and platelets. PMID: 12135673
42. The endogenous levels of TPO, IL-6 and IL-8 are elevated in the thrombocytopenic patients with AML and MDS. PMID: 12187073
43. induces megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1 PMID: 12359731
44. no difference was found in the cord blood level of thrombopoietin between infants born to mothers with pregnancy-induced hypertension and those without PMID: 12381927
45. review of TPO role in thrombopoiesis, signal transduction, cellular proliferative and anti-apoptotic mechanisms increasing megakaryocyte numbers PMID: 12430879
46. levels in children with acute and chronic idiopathic thrombocytopenic purpura and its relationship with mega-dose methylprednisolone therapy PMID: 12468916
47. Tpo concentrations in plasma samples taken concurrently from the right ventricle, the pulmonary artery, and the left ventricle showed there were positive correlations between the Tpo levels and pulmonary artery systolic pressure. PMID: 12487786
48. TPO stimulation of a megakaryocyte cell line activated lyn kinase, shown to be involved in the transduction pathway of the TPO proliferative signal. PMID: 12495897
49. Production of this protein in human hepatic cell cultures is not affected by IFN-alpha, IFN-beta, and IFN-gamma. PMID: 12581491
50. c-mpl mutations are the cause not only for the hypomegakaryocytic thrombocytopenia, but also for the development of an aplastic anemia (AA) in patients with CAMT PMID: 12799278

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HGNC: 11795

OMIM: 187950

KEGG: hsa:7066

STRING: 9606.ENSP00000204615

UniGene: Hs.1166