Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human Thy-1 membrane glycoprotein (THY1)

Recombinant Human Thy-1 membrane glycoprotein (THY1)

  • 货号：
    CSB-YP023525HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023525HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP023525HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023525HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023525HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CD7; CD90; CD90 antigen; CDw90; FLJ33325; MGC128895; T25; Theta antigen; Thy 1; Thy 1 cell surface antigen; Thy 1 membrane glycoprotein; Thy 1 T cell antigen; Thy 1.2; Thy-1 antigen; Thy-1 membrane glycoprotein; Thy1; Thy1 antigen; Thy1 T cell antigen; Thy1.1; Thy1.2; THY1_HUMAN; Thymus cell antigen 1, theta
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-130
  • 氨基酸序列
    Q KVTSLTACLV DQSLRLDCRH ENTSSSPIQY EFSLTRETKK HVLFGTVGVP EHTYRSRTNF TSKYNMKVLY LSAFTSKDEG TYTCALHHSG HSPPISSQNV TVLRDKLVKC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
  • 基因功能参考文献：
    1. High CD90 expression is associated with lymph node metastasis in intrahepatic cholangiocarcinoma. PMID: 30196535
    2. Data indicate that CD90 is an actor of glioblastoma (GBM) invasiveness through SRC-dependent mechanisms. PMID: 28939749
    3. Results show that CD90 distinguishes two interrelated, yet functionally distinct pericyte populations in the adult human brain that may have discrete roles in neurovascular function, immune response and scar formation. PMID: 27215737
    4. number of Thy-1(+) human peritoneal fibroblasts increased significantly in peritoneal dialysis patients PMID: 28724609
    5. CD90, CD166, and GD2 were identified as potential cancer stem cell markers. PMID: 27049037
    6. hese results suggest that LNGFR(+)THY-1(+) cells identified following NCLC induction from ESCs/iPSCs shared similar potentials with multipotent MSCs. PMID: 27178356
    7. High THY1 expression is associated with lung cancer. PMID: 27513329
    8. co-expression of CD90 and CD24 may have an important role in the development and progression of pancreatic intraepithelial neoplasia. PMID: 27332878
    9. Low CD90 expression is associated with ovarian cancer. PMID: 27633757
    10. Positive Thy1 and CD49f expression is significantly associated with the progression and poor prognosis of chondrosarcoma. PMID: 27155928
    11. CD90 could be used as a potential biomarker for Hepatocellular Carcinoma liver cancer stem cells, and cancer stem cell activity was elevated through up activated Notch pathway in CD90+ liver cancer stem cells. PMID: 26848615
    12. CD90 controls the differentiation of mesenchymal stromal cells by acting as an obstacle in the pathway of differentiation commitment. PMID: 27465541
    13. CD105+/CD90+ subpopulation from breast cancer MDA-MB-231 cells possesses "mesenchymal stem cell-like" characteristics, and its high migratory ability might be associated with epithelial-mesenchymal transformation. PMID: 26191205
    14. we found that THY-1 mediates human cytomegalovirus infection at the entry step and is important for infection PMID: 26147640
    15. CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA. PMID: 26272696
    16. CD90 could serve as a promising marker for pancreatic adenocarcinoma. PMID: 25536077
    17. Dynamic catch of a Thy-1-integrin alpha5beta1+syndecan-4 trimolecular complex explains extraordinary cancer cell adhesion to the vascular endothelium. PMID: 25216363
    18. these data suggest that CD90+CXCR4+ HCC cells may be CTSCs and selective elimination of these cells may substantially improve the current hepatocellular carcinoma therapy by reducing cancer metastasis. PMID: 25672610
    19. CD133, CD44, and CD90 could be used as prognostic and predictive markers in hepatoblastoma. PMID: 25168019
    20. Wnt/beta-catenin aids in regulating the proliferation of hepG2 cells mediated by thy-1. PMID: 25061736
    21. THY1 may be a promising novel prognostic marker for male breast cancer. PMID: 24194916
    22. We found that the vast majority of CD90(+) dermal cells are perivascularly located and generate a significantly higher percentage of regulatory T cells compared with cells expressing markers such as CD271 in vitro. PMID: 25050599
    23. TLR4 activation enhances the PD-L1-mediated tolerogenic capacity of colonic CD90+ stromal cells. PMID: 25070848
    24. In the present study we analyzed the expression of four cell surface antigens relevant to human hematopoiesis-CD90, CD96, CD117, and CD123-in bone marrow from pediatric acute myeloid leukemia patients and normal control subjects. PMID: 24751333
    25. Results indicate the importance of CD90 in the hepatocellular carcinoma (HCC). PMID: 24116172
    26. These findings suggest that CD90 could be a potential marker of lung cancer stem cells and thus provide new insight into further therapeutic strategies of lung cancer. PMID: 24101104
    27. CD90 is a diagnostic marker to differentiate between malignant pleural mesothelioma and lung carcinoma with immunohistochemistry. PMID: 24045552
    28. These results indicate that suppression of the RhoA-mediated pathway might participate in the Thy-1-induced migration inhibition in human umbilical vein endothelial cells. PMID: 23613866
    29. Positive correlation of Oct4 and ABCG2 to chemotherapeutic resistance in CD90(+)CD133(+) liver cancer stem cells. PMID: 23438193
    30. High CD90 tumor-initiating cell population is associated with an aggressive signature and metastatic capacity in esophageal cancer. PMID: 23382045
    31. We demonstrated that the expression of CSC marker CD90 is related to the expression of BORIS in hepatocellular carcinoma (HCC) tissue and HCC cell lines. PMID: 23237599
    32. Thy-1 contributes to metastasis of melanoma cells by mechanisms involving a Thy-1-mediated adhesion of melanoma cells to endothelial cells. PMID: 23159525
    33. concentrations were increased in the sera of systemic sclerosis patients, particularly in those with vascular involvement of the lungs PMID: 22807289
    34. an increased chondrogenic potential within the CD90+ fraction of human and canine synovial fluid mesenchymal progenitor cells PMID: 22952721
    35. The researchers demonstrate the role of CD90 as a marker of cancer stem cells within high-grade gliomas PMID: 22426060
    36. CD90 is not only a potential prognostic marker for high-grade gliomas but also a marker for cancer stem cells within gliomas PMID: 22203689
    37. human CD90 identifies a subset of Th17 and Tc17 cells within CD4(+) and CD8(+) T cells, respectively, which are depleted during HIV infection PMID: 22184726
    38. binding of leukocytes to activated endothelium mediated by the interaction of CD97 with Thy-1 is involved in firm adhesion of polymorphonuclear cells during inflammation and may play a role in the regulation of leukocyte trafficking to inflammatory sites. PMID: 22210915
    39. Data show that a cell population with the CD90 phenotype is enriched in sphere-cultured cells from gastric primary tumors. PMID: 21743497
    40. overexpression of Thy1 may not suppress the development of hepatocellular carcinoma(HCC) Thy1 could provide a clinical prognostic marker for HC PMID: 21272924
    41. Loss of Thy-1 in human lung fibroblasts induces a fibrogenic phenotype. PMID: 21577212
    42. we have identified a stromal cell type (CD90+ fibroblasts) and a molecule (CD90) that distinguishes cancer-associated stroma from 'benign' stroma in the prostate PMID: 20562849
    43. The decreased level of THY1 expression may be related with the occurrence and development of ovarian serous cystadenocarcinoma. PMID: 19538887
    44. Down-regulated/loss expression of THY1 protein in epithelial ovarian cancer is significantly correlated with cancer cell proliferation and metastasis in the epithelial ovarian cancer. PMID: 19615261
    45. Thy-1-integrin alpha(v)beta(5) interactions inhibit contraction-induced latent TGF-beta1 activation, presumably by blocking the binding of extracellular matrix-bound latent TGF-beta1 with integrin alpha(v)beta(5). PMID: 20463011
    46. Loss of expression of THY1 is associated with nasopharyngeal carcinoma. PMID: 19921696
    47. the distribution and proportion of CD90 positive cells in thyroid associated ophthalmopathy (TAO) and normal orbital tissue PMID: 17243294
    48. down-regulated KLF4, CHGA,GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA is an 8-gene signature for gastric cancer PMID: 20043075
    49. Review article on CD90 structure and function. PMID: 11860231
    50. Thy-1/Thy-1 ligand interaction may play a role in adhesion of melanoma cells to endothelial cells PMID: 12074634

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 数据库链接：

    HGNC: 11801

    OMIM: 188230

    KEGG: hsa:7070

    STRING: 9606.ENSP00000284240

    UniGene: Hs.644697