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  4. Recombinant Human Thyroid hormone receptor alpha (THRA)

Recombinant Human Thyroid hormone receptor alpha (THRA)

  • 货号：
    CSB-EP023510HU
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    THRA
  • Uniprot No.：
  • 别名：
    c-erbA-1; C-erbA-alpha; EAR-7; ERBA 1; ERBA; ERBA related 7; Nuclear receptor subfamily 1 group A member 1; THA_HUMAN; THRA; Thra1; Thra2; Thyroid hormone receptor alpha 1; Thyroid hormone receptor alpha 2; Thyroid hormone receptor alpha; TR alpha 1; TR alpha 2; Tra1; Triiodothyronine receptor; V-erbA-related protein 7
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    68.8 kDa
  • 表达区域：
    1-490aa
  • 氨基酸序列
    MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVCEDLAGNAASP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-B2M-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.; Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.
  • 基因功能参考文献：
    1. Thyroid receptors (TRalpha and TRbeta) are major components of the thyroid hormone pathway which is linked to neuronal development. PMID: 28856816
    2. overview of the clinical features together with the underlying molecular mechanisms in patients with resistance to thyroid hormone due to heterozygous mutations in TRalpha (Review). PMID: 28527577
    3. We found that the thyroid hormone receptor (TRalpha 3) has a differential expression profile. Thyroid hormone is critical for normal brain development. Our results showed that there is a possible link between IGF1/IGF1R and the TRalpha 3 and that over expression of IGF1R in RTT cells may be the cause of neurites improvement in neural RTT-derived neurons. PMID: 28007906
    4. This large case series underlines the variation in the clinical phenotype of RTHalpha patients. PMID: 27144938
    5. THRA predominates in multipotent human adipose derived stem cells (hADSC) whereas THRB is expressed at lower levels and is upregulated during hADSC differentiation. PMID: 27732649
    6. The expression of thyroid receptor alpha is linked to fertility status. PMID: 26715425
    7. 8 different THRA gene abnormalities have been described in 14 patients from 9 families with phenotypes including short stature, dysmorphic syndrome, psychoneuromotor disorders, constipation and bradycardia. Review. PMID: 26585273
    8. The current study aimed to investigate whether TRs may be specifically expressed in BRCA1 associated cancer cases. PMID: 26029931
    9. THRA mutations may be more common than expected. In patients with clinical symptoms of mild hypothyreosis without confirmation in endocrine studies, a molecular study of THRA defects is strongly recommended. PMID: 25670821
    10. Thyroid hormone receptor (TRalpha1) is shown to occur and determine postischemic remodeling and cardiac recovery depending on the availability of TH. [review] PMID: 25501869
    11. Data suggest thyroid hormone resistance syndrome can be exhibited by patients with heterozygous missense mutation (Ala263Val) in THRA1 and THRA2, isoforms resulting from alternative splicing. [CASE REPORT] PMID: 24969835
    12. THRalpha rs939348 polymorphism was associated with L-T4 dose and central obesity among hypothyroid patients. PMID: 25079464
    13. Thyroid hormone signalling may be important in a proportion of breast cancers and THRalpha2 expression may be a regulator of signalling in this pathway. PMID: 25542270
    14. substantial reduction in the protein expression profile of THRs in malignant versus nonmalignant mammary epithelium suggesting a possible role in breast cancer development. PMID: 24162265
    15. A new x-ray crystallographic structure of thyroid hormone receptor ligand-binding domains shows a second binding site for thyroid hormones. PMID: 24552590
    16. Transactivation of reporter genes in response to T4 thyroid hormone was dependent on the thyroid hormone receptor subtypes in human cells. PMID: 24673558
    17. Thyroid hormone receptor alpha mutation is associated with a severe and thyroxine-resistant skeletal dysplasia. PMID: 24914936
    18. TRalpha1 and TRbeta1, preferentially partner with distinct panels of auxiliary proteins. PMID: 24325866
    19. THRA gene polymorphisms are associated with obesity development. This is a novel observation linking the THRA locus to metabolic phenotypes. PMID: 23399772
    20. Mutations affecting THRA are not a common cause of high BMD in healthy euthyroid post-menopausal women. PMID: 24480136
    21. Adult female with defective TRalpha defines a shared phenotype in TRalpha-mediated resistance to thyroid hormone, with differential tissue responses to T4 treatment. PMID: 23940126
    22. Studies indicate that thyroid hormone receptors alpha and beta (TRTHRA and THRB) genes mutations has been identified in thyroid tumours. PMID: 23271024
    23. Data from 2 patients (daughter; father) from Greece with frameshift mutation in exon 9 of TRalpha1 (F397fs406X) resulting in new type of thyroid hormone resistance suggest that some symptoms are improved with levothyroxine treatment, others are not. PMID: 23633213
    24. thyroid hormone receptor action varies by subtype and could could influence physiologic and pharmacologic responses to THs and selective TR modulators (STRMs) PMID: 23300972
    25. IGFBP-3 interacts with TRalpha1 and inhibits triiodothyronine responsive gene transcription. PMID: 21529443
    26. conjugation of SUMO to TR has a TR-isoform preference and is important for T3-dependent gene induction and repression. PMID: 22930759
    27. Thyroid hormone receptor-alpha/NR1D1 polymorphisms were not associated with baseline characteristics, including serum TSH and free thyroxine. None of the polymorphisms were associated with bone mineral density or osteoporotic fractures. PMID: 22224817
    28. Our data indicates that the IGFBP-6 can interact with thyroid hormone receptor alpha 1 and interfere with heterodimer formation with retinoid x receptor PMID: 21997736
    29. our study showed associations between the THRA rs939348 polymorphism and systolic blood pressure and the risk of hypertension but not with coronary heart disease. PMID: 21654857
    30. TR mutations from renal clear cell carcinoma and hepatocellular carcinoma may play tissue-specific roles in carcinogenesis. PMID: 21622534
    31. Differential interaction of NCoR1 with TR isoforms accounted for the TR isoform-dependent regulation of adipogenesis and that aberrant interaction of NCoR1 with TR could underlie the pathogenesis of lipid disorders in hypothyroidism. PMID: 21389087
    32. investigation of association/dissociation kinetics for recombinant TRalpha and ligand (125I-T3) PMID: 21508093
    33. The relationship between the genetic variability of the THRA gene and Alzheimer disease risk remains uncertain but cannot be entirely excluded. PMID: 19427062
    34. Results highlight v-ErbA's complex mode of action: the oncoprotein is highly mobile and trafficks between the nucleus, cytoplasm, and aggresome, carrying out distinct activities within each compartment. PMID: 21075170
    35. We found TSHR, TRalpha1, TRalpha2 and TRbeta1 mRNA and proteins expressed in human endometrium PMID: 20691434
    36. Patients with non-septic shock non-thyroidal illness syndrome show decreased expression of thyroid hormone receptors THRalpha1 and THRbeta in skeletal muscle. PMID: 20736347
    37. The natural TH 3,5,3'-triodothyroacetic acid (Triac) exhibits a previously unrecognized mechanism of TRbeta selectivity. PMID: 19926848
    38. The presence of TRs in the penis provides the biological basis for the direct action of thyroid hormones on this organ. PMID: 20141582
    39. Data suggest that CDK8 plays an important coactivator role in thyroid hormone receptor (TR)-dependent transcription by promoting Pol II recruitment and activation at TR target gene promoters. PMID: 20231357
    40. A bioassay to evaluate the thyroid disrupting potential of industrial chemical using human TRalpha or TRbeta in S. cerevisiae is described. PMID: 19853653
    41. Genes for TR-alpha were differentially expressed in subcutaneous vs. omental adipose tissue. Findings suggest that TR alpha1 could contribute to SC adipose tissue expandability in obese subjects. PMID: 19360007
    42. A conserved lysine in the thyroid hormone receptor-alpha1 DNA-binding domain, mutated in hepatocellular carcinoma, is an allosteric sensor for transcription and contribute to neoplastic disease. PMID: 20053725
    43. analysis of isoform-specific transcriptional activity of overlapping target genes that respond to thyroid hormone receptors alpha1 and beta1 PMID: 19628582
    44. TR expression in human haematopoietic cells depends on thyroid function status, both hypo- and hyperthyroidism significantly influence clonogenicity and induce apoptosis in CD34(+)-enriched stem cells PMID: 19903799
    45. neurodevelopmental functions of thyroid hormone signaling. PMID: 11861164
    46. affected receptor amino acid sequences. lost their trans-activation function and exhibited dominant negative activity. PMID: 11889175
    47. Our results reveal specific alterations in the expression of TRbeta and TRalpha genes in a subset of breast cancer patients, suggesting that deregulation of thyroid hormone target genes may be involved in the generation of this neoplasia. PMID: 12082618
    48. Less aggressive thyroid cancer was found to be linked to increased thyroid hormone receptor-alpha1 expression and an expanded THRA1 microsatellite. PMID: 12231529
    49. allosteric changes resulting from binding of T3Ralpha to different response elements, i.e. pHREs versus nHREs, dictate whether a cofactor will function as a coactivator or a corepressor PMID: 12388540
    50. the nTRE (negative thyroid hormone response element) is responsible for binding of thyroid hormone receptor alpha to the promoter in HeLa cells PMID: 12878587

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  • 相关疾病：
    Hypothyroidism, congenital, non-goitrous, 6 (CHNG6)
  • 亚细胞定位：
    Nucleus.; [Isoform Alpha-2]: Cytoplasm. Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family, NR1 subfamily
  • 数据库链接：

    HGNC: 11796

    OMIM: 190120

    KEGG: hsa:7067

    STRING: 9606.ENSP00000264637

    UniGene: Hs.724