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  4. Recombinant Human Transcobalamin-1 (TCN1)

Recombinant Human Transcobalamin-1 (TCN1)

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  • 中文名称：
    人TCN1重组蛋白
  • 货号：
    CSB-YP023317HU
  • 规格：
    ￥1500
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    TCN1
  • Uniprot No.：
  • 别名：
    Haptocorin; Haptocorrin; HC; OTTHUMP00000235879; TC 1; TC I; TC-1; TC1; TCI; TCN 1; TCN1; TCO1_HUMAN; Transcobalamin 1; Transcobalamin I; Transcobalamin-1; Transcobalamin1; TranscobalaminI; Vitamin B12 binding protein; Vitamin B12 binding protein R binder family
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    Yeast
  • 分子量：
    47.6kDa
  • 表达区域：
    24-433aa
  • 氨基酸序列
    EICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDVSSGELALIILALGVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPITVTPPDSQSYISVNYSVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERSWGPYITCIQGLCANNNDRTYWELLSGGEPLSQGAGSYVVRNGENLEVRWSKY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：

    The product CSB-YP023317HU is a recombinant human transcobalamin-1 (TCN1) expressed in the yeast. Its target gene sequence corresponds to amino acids 24-433 of the human TCN1. The 6xHis-tag is fused to the protein at the N-terminus. Its purity is greater than 90% determined by SDS-PAGE. It migrated to the molecular weight band of 45-50 kDa. This recombinant TCN1 protein is a full-length of the mature protein. It is available now. The target protein TCN1 is a glycoprotein produced by the salivary glands of the mouth. The primary function of this protein is to protect cobalamin (Vitamin B12) from acid degradation in the stomach by producing a Haptocorrin-Vitamin B12 complex.

  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.
  • 基因功能参考文献：
    1. Higher placental TC protein abundance was associated with higher cord blood vitamin B12 concentrations, suggesting a potential role in vitamin B12 transport to the fetus. PMID: 27577703
    2. The variant rs526934 from the TCN1 gene was associated with an increased risk of developing gastric cancer. PMID: 26959381
    3. Levels of holotranscobalamin are decreased patients with cobalamin deficiency. PMID: 24057896
    4. Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin. PMID: 23846701
    5. TCN1 gene expression implicates disease progression in patient with middle ear cholesteatoma. PMID: 23670528
    6. comparison of human and rainbow trout cobalamin-binding protein PMID: 22872637
    7. Elevated concentrations of B(12) found in autoimmune lymphoproliferative syndrome patients were due to increased lymphocyte expression of haptocorrin. PMID: 22306884
    8. Stromal expression of KRT15, TCN1, and HOXB13 was significantly correlated with tumor grade, stromal hypercellularity, mitotic activity and microscopic borders. PMID: 21574054
    9. two novel mutations, each causing a premature stop codon - a genetic basis for TC I deficiency PMID: 19686235
    10. Comparative analysis of cobalamin binding kinetics PMID: 11788601
    11. No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease. PMID: 12590948
    12. interactions of COBALAMIN BINDING proteins with a number of ligands PMID: 17487979
    13. Maternal folate-related polymorphisms studied here (CBS, MTR, RFC-1, and TC) have no influence on trisomy 21 susceptibility in subjects of Brazilian population.v PMID: 19729796

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Eukaryotic cobalamin transport proteins family
  • 组织特异性：
    Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils.
  • 数据库链接：

    HGNC: 11652

    OMIM: 189905

    KEGG: hsa:6947

    STRING: 9606.ENSP00000257264

    UniGene: Hs.2012