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  4. Recombinant Human Transcription factor 21 (TCF21)

Recombinant Human Transcription factor 21 (TCF21)

  • 中文名称：
    人TCF21重组蛋白
  • 货号：
    CSB-YP023297HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TCF21重组蛋白
  • 货号：
    CSB-EP023297HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TCF21重组蛋白
  • 货号：
    CSB-EP023297HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TCF21重组蛋白
  • 货号：
    CSB-BP023297HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TCF21重组蛋白
  • 货号：
    CSB-MP023297HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TCF21
  • Uniprot No.：
  • 别名：
    bHLHa23; Capsulin; Class A basic helix-loop-helix protein 23; Epicardin; POD 1; Pod-1; POD1; Podocyte expressed 1; Podocyte-expressed 1; TCF-21; tcf21; TCF21_HUMAN; Transcription factor 21
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-179
  • 氨基酸序列
    MSTGSLSDVE DLQEVEMLEC DGLKMDSNKE FVTSNESTEE SSNCENGSPQ KGRGGLGKRR KAPTKKSPLS GVSQEGKQVQ RNAANARERA RMRVLSKAFS RLKTTLPWVP PDTKLSKLDT LRLASSYIAH LRQILANDKY ENGYIHPVNL TWPFMVAGKP ESDLKEVVTA SRLCGTTAS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.
  • 基因功能参考文献：
    1. TCF21 inhibits gastric cancer growth and chemoresistance possibly through the AKT signaling pathway PMID: 30296564
    2. we concluded that decreased mRNA expression of TCF21 is a predictor for poor prognosis in patients with lung adenocarcinoma. PMID: 28515486
    3. TCF21 is downregulated in ESCC, and its low expression is closely correlated with N stage and predicts a poor prognosis. TCF21 functions as a tumor suppressor in ESCC progression, and enhancement of its expression levels may be partly through promoting Kiss-1 expression to reverse EMT by modulating EMT-related gene expression. PMID: 29909422
    4. TCF21 modulates Steroidogenic factor-1 and estrogen receptor beta expression through the recruitment of USF2 in endometriotic stromal cells. PMID: 30018006
    5. TCF21, a hypoxia-driven p53 target, functions as a tumor suppressor in uterine corpus endometrial cancer and presents as a therapeutic target for tumor treatment. PMID: 29608330
    6. Genetic polymorphisms of TCF21 are potentially predictive for osteosarcoma risk and outcomes. PMID: 28663539
    7. TCF21 rs12190287 polymorphism can regulate TCF21 expression and may serve as a potential marker for genetic susceptibility to breast cancer. PMID: 27270650
    8. There were significant differences in the genotype and allele frequencies of rs12190287 between the cases and controls in a Chinese population. Allele G of rs12190287 was significantly associated with an increased risk of Ventricular Septal Defects in a Chinese population. PMID: 28346832
    9. Transcription Factor 21 is downregulated in adrenocortical carcinoma cells. Taken together, these findings support the hypothesis that Transcription Factor 21 is a regulator of steroidogenic factor 1 and is a tumor suppressor gene in pediatric and adult adrenocortical tumors. PMID: 28658440
    10. TCF21 binds to AHR, promotes expression of AHR to upregulate inflammation-related genes in coronary artery smooth muscle. PMID: 28481916
    11. Association of miR-146a rs2910164 and TCF21 rs12190287 with CAD in an Iranian population. PMID: 26909569
    12. These findings show that POD-1/TCF21 regulates SF-1 and LRH-1 by distinct mechanisms, contributing to the understanding of POD-1 involvement and its mechanisms of action in adrenal and liver tumorigenesis. PMID: 26421305
    13. TCF21 may function as a tumor suppressor gene, which is downregulated through promoter hypermethylation in CRC development. PMID: 26435499
    14. The presence of significant hypermethylation of TCF21 supports the hypothesis that hypermethylation of TCF21 and/or decreased TARID expression lies within the pathogenic pathway of most CCSKs. PMID: 26158413
    15. our data provided the first evidence that TCF21 mRNA is significantly downregulated in breast cancer cell lines and tissues and regulates breast cancer cell proliferation and EMT. PMID: 26044559
    16. Separate enrichment analyses found over-representation of TCF21 target genes among CAD associated genes, and linkage disequilibrium between TCF21 peak variation and that found in GWAS loci consistent with the hypothesis that TCF21 may affect disease risk PMID: 26020271
    17. TCF21 could inhibit the proliferation and migration of SMMC-7721 hepatocellular carcinoma cells and promote its apoptosis PMID: 26146055
    18. Low TCF21 expression is associated with gastric cancer. PMID: 25156819
    19. TCF21 inhibits the proliferation and migration and facilitates early apoptosis of A549 cells. PMID: 24758904
    20. these data suggest that miR-224 interaction with the TCF21 transcript contributes to allelic imbalance of this gene, thus partly explaining the genetic risk for coronary heart disease associated at 6q23.2 PMID: 24676100
    21. Results show that TARID, an antisense lncRNA activates TCF21 expression by inducing promoter demethylation. PMID: 25087872
    22. These findings, together with its stage- and primary site-dependent expression, turn TCF21 into a promising candidate biomarker in head and neck squamous cell carcinoma. PMID: 23529585
    23. Thus, both disease-related growth factor and embryonic signaling pathways may regulate CHD risk through two independent alleles at TCF21. PMID: 23874238
    24. study found that POD-1/TCF21 acts as a transcriptional suppressor of SF-1 gene expression in adrenocortical carcinoma cells; a possible mechanism involved in repression of SF-1 expression is through POD-1 binding to the E-box sequence in the SF-1 promoter region PMID: 23313103
    25. demonstrated that TCF21 was a significant prognosticator of cancer-specific survival PMID: 22862160
    26. Epigenetic downregulation of TCF21 is functionally involved in melanoma progression. PMID: 21771727
    27. Hypermethylation and decreased expression of TCF21 were tumor specific and very frequent in all NSCLCs, even early-stage disease. PMID: 20945327
    28. epicardin/capsulin/Pod-1 functions as a negative regulator of differentiation of myoblasts through transcription in cell growth arrest and lineage-specific differentiation PMID: 12493738
    29. analysis of TCF21 epigenetic regulation on 6q23-q24 in lung and head and neck cancer PMID: 16415157

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 11632

    OMIM: 603306

    KEGG: hsa:6943

    STRING: 9606.ENSP00000237316

    UniGene: Hs.78061