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  4. Recombinant Human Transcription factor SOX-1 (SOX1)

Recombinant Human Transcription factor SOX-1 (SOX1)

  • 中文名称：
    人SOX1重组蛋白
  • 货号：
    CSB-YP022417HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SOX1重组蛋白
  • 货号：
    CSB-EP022417HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SOX1重组蛋白
  • 货号：
    CSB-EP022417HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SOX1重组蛋白
  • 货号：
    CSB-BP022417HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SOX1重组蛋白
  • 货号：
    CSB-MP022417HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Sex determining region Y box 1; sox1; SOX1_HUMAN; SRY; SRY box containing gene 1; SRY related HMG box gene 1; Transcription factor Sox-1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-391
  • 氨基酸序列
    MYSMMMETDL HSPGGAQAPT NLSGPAGAGG GGGGGGGGGG GGGAKANQDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK VMSEAEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLL KKDKYSLAGG LLAAGAGGGG AAVAMGVGVG VGAAAVGQRL ESPGGAAGGG YAHVNGWANG AYPGSVAAAA AAAAMMQEAQ LAYGQHPGAG GAHPHAHPAH PHPHHPHAHP HNPQPMHRYD MGALQYSPIS NSQGYMSASP SGYGGLPYGA AAAAAAAAGG AHQNSAVAAA AAAAAASSGA LGALGSLVKS EPSGSPPAPA HSRAPCPGDL REMISMYLPA GEGGDPAAAA AAAAQSRLHS LPQHYQGAGA GVNGTVPLTH I
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation.
  • 基因功能参考文献：
    1. SOX1 overlapping transcript was found to be highly expressed in differentiated neural stem cells across different time points of differentiation, and its expression correlated with SOX1 gene expression. PMID: 28674729
    2. The sensitivity was found to be 62% and 83% for DAPK1 and SOX1, respectively, when analyzed separately in the singleplex assay, but increased to 90% in the multiplex assay when either or both of the SOX1 and the DAPK1 gene promoters showed methylation. PMID: 27452040
    3. Taken together, these data suggest that SOX1 can function as a tumor suppressor partly by interfering with Wnt/beta-catenin signaling in breast cancer. PMID: 27206213
    4. the under-expression of SOX1 was associated significantly with SALL4 overexpression. This study was the first to evaluate SOX1 underexpression and its association with poor prognosis in esophageal squamous cell carcinoma. PMID: 27576349
    5. The results of the SRY gene amplification of plasma DNA from pregnant women was the same as that of the amniocyte DNA PMID: 26782455
    6. The analysis identified a signaling axis between FGF signaling and the transcription factor Sox1, which is preferentially expressed in stem- and mesenchymal-like breast cancers. PMID: 26365194
    7. downregulation of SOX-1 was correlated with poor prognosis and tumor development in hepatocellular carcinoma. PMID: 26191244
    8. SOX 1 suppressed cell growth and invasion in Tu212 cells by inhibiting Wnt pathway, and the anti-tumor effect of SOX 1 could be weakened by SOX 2, which may be a potential molecular basis for clinical treatment of laryngeal squamous cell carcinoma . PMID: 26040764
    9. Our results suggest that SOX1 is epigenetically silenced in the majority of NSCLC and restoration of SOX1 inhibited cell migration by regulating actin cytoskeletal remodeling in NSCLC. PMID: 25613070
    10. SOX1 decreases the expression of beta-catenin in a proteasome-independent manner. PMID: 25427424
    11. PAX1 and SOX1 DNA methylation correlate with a cervical intraepithelial neoplasia diagnosis. PMID: 24799352
    12. we successfully established a three-step inducing protocol to derive Neural stem cells from adipose-derived mesenchymal stem cells with high purity by Sox1 activation PMID: 24138016
    13. The methylation index of SOX1 recovered from scrapings of uterine cervix adenocarcinomas is significantly higher than in normal controls. PMID: 24407576
    14. Taken together, these data suggest that SOX1 can function as a tumor suppressor partly by interfering with Wnt/beta-catenin signaling in cervical cancer. PMID: 23927962
    15. Inactivation of SOX1 gene is associated with cisplatin resistance in human non-small cell lung cancer cell. PMID: 23994634
    16. Concomitant epigenetic silencing of SOX1 and SFRPs through promoter hypermethylation is frequent in hepatocellular carcinoma, and this might contribute to abnormal activation of canonical Wnt signal pathway. PMID: 23215838
    17. The level and timing of SOX1 expression affects neural induction as well as neural lineage. PMID: 22860217
    18. These findings suggest that SOX1 might function as an important tumor suppressor during the development of hepatocellular carcinoma. PMID: 22767186
    19. SOX1 antibodies are a specific marker for SCLC-LEMS but they are also found in SCLC patients without paraneoplastic neurological syndromes PMID: 23278580
    20. Transgenic interneuron diversification in the p2 domain is more complex than previously thought and directly implicates Sox1 in this process. PMID: 20844123
    21. Supratentorial PNETs expressed significantly higher levels of SOX2, NOTCH1, ID1, and ASCL-1 transcripts. PMID: 20515335
    22. Sox1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. PMID: 15110721
    23. The detection of SOX1 antibodies in patients with Lambert-Eaton myasthenic syndrome (LEMS) predicts the presence of small cell lung cancer and may be used to follow more closely those LEMS patients with no evidence of cancer at the initial workup. PMID: 18032743
    24. expression of Sox1, Sox2 and Sox9 was detected at the mRNA level in both foetal and adult cerebellum samples; Sox1, Sox2 and Sox9 expression was detected in the Purkinje cell layer of the adult cerebellum PMID: 19061938
    25. Data show that SOX antibodies have diagnostic value in discriminating SCLC-LEMS from nontumor LEMS, but have no relation to survival in patients with SCLC. PMID: 19667272
    26. A similar protein directly regulates the gamma-crystallin genes and is essential for lens development in mice. PMID: 9512512

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Mainly expressed in the developing central nervous system.
  • 数据库链接：

    HGNC: 11189

    OMIM: 602148

    KEGG: hsa:6656

    STRING: 9606.ENSP00000330218

    UniGene: Hs.202526