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  4. Recombinant Human Transcriptional repressor protein YY1 (YY1)

Recombinant Human Transcriptional repressor protein YY1 (YY1)

  • 中文名称：
    人YY1重组蛋白
  • 货号：
    CSB-YP026297HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人YY1重组蛋白
  • 货号：
    CSB-EP026297HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人YY1重组蛋白
  • 货号：
    CSB-EP026297HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人YY1重组蛋白
  • 货号：
    CSB-BP026297HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人YY1重组蛋白
  • 货号：
    CSB-MP026297HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    YY1
  • Uniprot No.：
  • 别名：
    CF1; Delta; Delta transcription factor; INO80 complex subunit S; INO80S; NF E1; NF-E1; NFE1; OTTHUMP00000197459; Transcriptional repressor protein YY1; TYY1_HUMAN; UCR motif DNA binding protein; UCRBP; Yin and yang 1; Yin and Yang 1 protein; Yin Yang 1; Ying Yang 1; YY 1; YY 1 transcription factor; YY-1; YY1; YY1 transcription factor
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-414
  • 氨基酸序列
    MASGDTLYIA TDGSEMPAEI VELHEIEVET IPVETIETTV VGEEEEEDDD DEDGGGGDHG GGGGHGHAGH HHHHHHHHHH PPMIALQPLV TDDPTQVHHH QEVILVQTRE EVVGGDDSDG LRAEDGFEDQ ILIPVPAPAG GDDDYIEQTL VTVAAAGKSG GGGSSSSGGG RVKKGGGKKS GKKSYLSGGA GAAGGGGADP GNKKWEQKQV QIKTLEGEFS VTMWSSDEKK DIDHETVVEE QIIGENSPPD YSEYMTGKKL PPGGIPGIDL SDPKQLAEFA RMKPRKIKED DAPRTIACPH KGCTKMFRDN SAMRKHLHTH GPRVHVCAEC GKAFVESSKL KRHQLVHTGE KPFQCTFEGC GKRFSLDFNL RTHVRIHTGD RPYVCPFDGC NKKFAQSTNL KSHILTHAKA KNNQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation.; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.
  • 基因功能参考文献：
    1. Data show that MiR-147b targets the 3' untranslated region (3'UTR) of Yin Yang 1 (YY1). PMID: 30060075
    2. Results show that YY1 is phosphorylated by c-Abl kinase at tyrosine residue 254 and that this phosphorylation likely modulates its transcriptional activity. PMID: 29807053
    3. YY1-CDKN3-MDM2/P53-P21 axis is involved in pancreatic tumorigenesis PMID: 29168185
    4. The repression of TBX21 expression by high-affinity binding of YY1 to the -1993C allele may contribute to a decreased development of AIH-1 via suppression of type 1 immunity. PMID: 29358858
    5. expression of miR-192-5p was negatively correlated with that of YY1 in bladder cancer tissues PMID: 29536411
    6. YY1 promoted glioma cell proliferation and miR218 could inhibit glioma cell proliferation by targeting YY1. PMID: 29138857
    7. miR-30a acts in a feedback loop to modulate the pro-autophagic activities of YY1. PMID: 29052509
    8. Data suggest a role for YY1 transcription factor (YY1) in transcriptional activity on inactive X (Xi) in general through sequence-specific binding, and its involvement at superloop anchors. PMID: 27857184
    9. Results suggest that up-regulation of YY1 is closely associated with the progression of cervical squamous cell carcinoma, and YY1 may play an important role in the pathogenesis of cervical cancer by modulating the expression of E-cadherin and HPV16 E6. PMID: 29470526
    10. Results show that histone deacetylase 1 (HDAC1) expression was positively correlated with YY1 transcription factor (YY1) in hepatocellular carcinoma (HCC) cell lines and primary tumor tissues. PMID: 28489564
    11. s found that YY1 and STAT1 were upregulated in ox-LDL-stimulating macrophages followed by translocation in the nucleus and binding to the transcriptional promoter region of miR-29a, thus leading to the increase of miR-29a expression. PMID: 28593745
    12. results support a model in which YY1 acts as an architectural protein to connect developmentally regulated looping interactions; the location of YY1-mediated interactions may be demarcated in development by a preexisting topological framework created by constitutive CTCF-mediated interactions. PMID: 28536180
    13. High expression of nuclear YY1 was significantly associated with higher AJCC stage and small vessel invasion. PMID: 28412749
    14. This is the first report on the status of YY1 T372R in insulinoma cases of Indian origin. PMID: 28472826
    15. YY1 promotes proliferation and migration with suppression of apoptosis via directly inhibiting MYCT1 in laryngeal cancer cells, suggesting that YY1 is a useful target as a potential oncogene in laryngeal cancer development and progression. PMID: 28485541
    16. These data suggested that YY1 may be important for apoptosis induction via the regulation of Fas during sepsis. Therefore, Fas may be a potential therapeutic target to prevent MOD through regulation of YY1 expression. Furthermore, YY1 and Fas expression in PBMCs may be used to as prognostic markers. PMID: 28447715
    17. Study shows that the ubiquitously expressed transcription factor Yin Yang 1 (YY1) contributes to enhancer-promoter structural interactions in a manner analogous to DNA interactions mediated by CTCF. PMID: 29224777
    18. YY1 was over-expressed in RA which can bind to the promotor of IL-6 to introduce IL-6 expression, contributing to the inflammation of RA via stimulation of Th17 differentiation. PMID: 27829535
    19. YY1 promotes apoptosis via upregulating Bax transcription and subsequent activation of Bax by translocation from the cytosol to the mitochondrial membrane. PMID: 27074573
    20. High YY1 expression is associated with Lung Cancer Progression. PMID: 28972861
    21. Low YY1 expression is associated with pancreatic ductal adenocarcinoma. PMID: 28867247
    22. PRE-PIK3C2B interacts directly with YY1 in vitro and recruits PRC2 complex in vivo. The localization of PcG proteins including YY1 to PRE-PIK3C2B in HEK cells is decreased on knock-down of either YY1 or SUZ12. PMID: 23805300
    23. YY1 promotes mTORC2-mediated AKT activation PMID: 26762111
    24. these results define a clinical syndrome caused by haploinsufficiency of YY1 through dysregulation of key transcriptional regulators. PMID: 28575647
    25. Interactions of the chromatin remodeling protein INO80 with DNA, and the role of YY1 in this process have been described. PMID: 27428271
    26. ZFs of YY1 are able to interact with multiple RNA sequences, and that their specificity is not limited to putative endogenous RNA target Xist. The mode of interaction appears to be distinct from both the DNA binding of YY1 and the RNA binding of other classical ZF proteins. PMID: 27369384
    27. the existence of both INO80 and YY1 is required for recruiting the INO80/YY1 complex to BCCIP promoter region. Our findings strongly indicate that BCCIP is a potential target gene of the INO80/YY1 complex. PMID: 27535137
    28. miR-215 is downregulated in colon cancer and it suppresses colon cancer cell proliferation, migration and invasion by directly targeting YY1 PMID: 27663660
    29. High YY1 expression is Associated with Endometrial Cancer. PMID: 27259051
    30. Our results suggested that YY1 depletion repressed prostate cancer cell viability and proliferation and induced apoptosis at least in a miR-146a-assisted manner. PMID: 28101571
    31. Knockdown of miR-381 target gene, YY1, mimicked the phenotype induced by miR-381 overexpression. PMID: 26768613
    32. SET7/SET9-mediated YY1 methylation was shown to be involved in YY1-regulated gene transcription and cell proliferation. PMID: 26902152
    33. The results of our study indicate that YY1 belongs to the family of intrinsically disordered proteins, which exist natively in a partially unfolded conformation. PMID: 25963536
    34. Study shows that YY1 regulates inflammatory responses in vascular endothelium through its binding to ANRIL. PMID: 26618242
    35. YY1 regulates lung CCL4 transcription in pulmonary tuberculosis. PMID: 26786659
    36. Significance of the pathogenic mutation T372R in the Yin Yang 1 protein interaction with DNA--thermodynamic studies: the mutation does not affect the secondary structure of either zinc fingers or the N-terminal fragment of the protein. PMID: 26910132
    37. YY1 overexpression contributes to EZH2 recruitment for H3K27me3-mediated silencing of tumour-suppressive microRNAs, thereby activating NF-kappaB signalling in hepatocarcinogenesis. PMID: 26800240
    38. IL-18 induced YY1 expression, which repressed FXR and MRP2 expression in HepG2 cells. PMID: 26292095
    39. YY1 is overexpressed in differentiated thyroid cancer, and more frequently overexpressed in the papillary carcinoma subtype. PMID: 25698133
    40. Results identify a novel YY1 ~ miR-9 ~ RYBP axis involved in melanoma tumorigenesis and reinforce the idea that regulatory circuitries involving miRNAs and TFs are prevalent mechanisms. PMID: 26104682
    41. Rescue experiments indicated that the suppressive effect of miR-34a on invasion and migration was mediated by activating YY1 expression. PMID: 25954903
    42. Results demonstrate that YY1 is a critical effecter in IL-13-induced fibroblast differentiation: increasing YY1 enhances it whereas decreasing YY1 reduces it. PMID: 25775215
    43. These findings imply that the T allele significantly suppresses PSCA expression in vivo by recruiting YY1 to its promoter, which eventually predisposes gastric epithelial cells to GC development PMID: 25727947
    44. Data show that YY1 transcription factor (YY1) is tyrosine-phosphorylated by Src family kinases, leading to down-regulation of its activity. PMID: 26198631
    45. YY1 is a transcription repressor of FEN1 regulating FEN1 levels in response to DNA damaging agents. PMID: 25885449
    46. These data demonstrate the crucial requirement for YY1 in lung morphogenesis. PMID: 26329601
    47. Transcription factor YY1 is critically involved in the chromatin remodeling and chromosomal interactions at the Th2 cytokine locus. PMID: 25764217
    48. The somatic Thr372Arg YY1 mutation is a relevant finding in female patients with sporadic insulinomas. PMID: 25763608
    49. YY1 is necessary to maintain the steady-state level of VEGFA expression while its silencing increases VEGFA mRNA half-life at 4 h and impairs the maturation of miRNA 200b/c. PMID: 25644713
    50. YY1 regulates, in a sex-specific manner, Mena expression in heart failure PMID: 25935483

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  • 相关疾病：
    Gabriele-de Vries syndrome (GADEVS)
  • 亚细胞定位：
    Nucleus matrix. Note=Associated with the nuclear matrix.
  • 蛋白家族：
    YY transcription factor family
  • 数据库链接：

    HGNC: 12856

    OMIM: 600013

    KEGG: hsa:7528

    STRING: 9606.ENSP00000262238

    UniGene: Hs.388927