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  4. Recombinant Human Trem-like transcript 1 protein (TREML1), partial

Recombinant Human Trem-like transcript 1 protein (TREML1), partial

  • 中文名称：
    人TREML1重组蛋白
  • 货号：
    CSB-YP771477HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TREML1重组蛋白
  • 货号：
    CSB-EP771477HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TREML1重组蛋白
  • 货号：
    CSB-EP771477HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TREML1重组蛋白
  • 货号：
    CSB-BP771477HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TREML1重组蛋白
  • 货号：
    CSB-MP771477HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TREML1
  • Uniprot No.：
  • 别名：
    dJ238O23.3; GLTL1825; MGC119173; PRO3438; TLT 1; TLT-1; TLT1; TREM like transcript 1; Trem like transcript 1 protein; Trem-like transcript 1 protein; TREML 1; Treml1; Triggering receptor expressed on myeloid cells like 1; Triggering receptor expressed on myeloid cells like protein 1; Triggering receptor expressed on myeloid cells-like protein 1; TRML1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell surface receptor that may play a role in the innate and adaptive immune response.
  • 基因功能参考文献：
    1. Study characterized the expression of TREM genes in cerebellum and temporal cortex and determined TREML1 and TREM2 to be the only reliably expressed TREM genes in these brain regions; identified rs9357347 as a putative regulatory variant that is associated with protection from Alzheimer's disease and with increased TREML1 and TREM2 brain levels. PMID: 27939925
    2. Levels of sTLT-1 in plasma from patients with potential acute coronary syndrome were compared with an age-matched control group with similar risk factors for cardiovascular disease. PMID: 25147325
    3. Platelet-derived soluble TLT-1 is a potent endogenous regulator of sepsis-associated inflammation. PMID: 22551551
    4. Serum sTREM-1 level measurements may be helpful in diagnosing and predicting outcome for non-tuberculous mycobacterial lung disease. PMID: 22283904
    5. These results suggest that during inflammation, sTLT-1 may mediate hemostasis by enhancing actin polymerization, resulting in increased platelet aggregation and adherence to the endothelium. PMID: 20093931
    6. initial characterization of TREM-like transcript (TLT)-1 results indicate it is likely that TLT-1 regulates the signaling of the TREM family receptors(TLT-1) PMID: 12393607
    7. In contrast to previously characterized immunoreceptor tyrosine-based inhibition motif (ITIM) receptors, TLT1 enhances rather than inhibits calcium signaling in rat RBL-2H3 cells, a property dependent on the SHP-2 recruiting classical Tyr281 ITIM. PMID: 15128762
    8. A soluble fragment of the TLT-1 extracellular domain is found in serum of humans and mice and that an isoform of similar mass is released from platelets following activation with thrombin. PMID: 16505478
    9. Define a platelet specific function for TLT1 in regulation of aggregation. PMID: 17549298
    10. Phenotypic heterogeneity in the Gray platelet syndrome extends to the expression of TREM family member, TLT-1. PMID: 18612537
    11. antibody against the extracellular domain inhibits platelet aggregation in vitro PMID: 19230638
    12. TLT-1 plays a protective role during inflammation by dampening the inflammatory response and facilitating platelet aggregation at sites of vascular injury PMID: 19436112

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151). Transported to the cell surface after stimulation by thrombin (PubMed:15100151). Soluble fragments can be released into the serum by proteolysis (PubMed:16505478).
  • 组织特异性：
    Detected in platelets, monocytic leukemia and in T-cell leukemia.
  • 数据库链接：

    HGNC: 20434

    OMIM: 609714

    KEGG: hsa:340205

    STRING: 9606.ENSP00000402855

    UniGene: Hs.117331