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  4. Recombinant Human Trem-like transcript 2 protein (TREML2), partial

Recombinant Human Trem-like transcript 2 protein (TREML2), partial

  • 货号：
    CSB-YP729201HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP729201HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP729201HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP729201HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP729201HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TREML2
  • Uniprot No.：
  • 别名：
    TREML2; C6orf76; TLT2; UNQ6268/PRO20473; Trem-like transcript 2 protein; TLT-2; Triggering receptor expressed on myeloid cells-like protein 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.
  • 基因功能参考文献：
    1. Mutation of TREML2 is a major factor leading to ankylosing spondylitis for HLA-B27 (+) members in a large family and that TREML2 is also a susceptibility gene promoting the development of ankylosing spondylitis in HLA-B27 (+) individuals. PMID: 29778423
    2. A missense variant in TREML2 was associated with a reduced risk of Alzheimer's Disease in a Han Chinese population. PMID: 26797517
    3. Study characterized the expression of TREM genes in cerebellum and temporal cortex and determined TREML1 and TREM2 to be the only reliably expressed TREM genes in these brain regions; identified rs9357347 as a putative regulatory variant that is associated with protection from Alzheimer's disease and with increased TREML1 and TREM2 brain levels. PMID: 27939925
    4. Missense variant in TREML2 protects against Alzheimer's disease. PMID: 24439484
    5. TLT2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation. PMID: 16670310
    6. analysis of an interaction between B7-H3 and TLT-2 that preferentially enhances CD8(+) T cell activation PMID: 18650384
    7. Data do not point to a role for TREML2 as a receptor for B7-H3. PMID: 19544488

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.
  • 数据库链接：

    HGNC: 21092

    OMIM: 609715

    KEGG: hsa:79865

    STRING: 9606.ENSP00000418767

    UniGene: Hs.164797