Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human Tribbles homolog 1 (TRIB1)

Recombinant Human Tribbles homolog 1 (TRIB1)

  • 货号：
    CSB-YP836296HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP836296HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP836296HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP836296HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP836296HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TRIB1
  • Uniprot No.：
  • 别名：
    C8FW; G-protein-coupled receptor-induced gene 2 protein; GIG-2; GIG2; SKIP1; TRB-1; TRB1; Trib1; TRIB1_HUMAN; Tribbles homolog 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-372
  • 氨基酸序列
    MRVGPVRSAM SGASQPRGPA LLFPATRGVP AKRLLDADDA AAVAAKCPRL SECSSPPDYL SPPGSPCSPQ PPPAAPGAGG GSGSAPGPSR IADYLLLPLA EREHVSRALC IHTGRELRCK VFPIKHYQDK IRPYIQLPSH SNITGIVEVI LGETKAYVFF EKDFGDMHSY VRSRKRLREE EAARLFKQIV SAVAHCHQSA IVLGDLKLRK FVFSTEERTQ LRLESLEDTH IMKGEDDALS DKHGCPAYVS PEILNTTGTY SGKAADVWSL GVMLYTLLVG RYPFHDSDPS ALFSKIRRGQ FCIPEHISPK ARCLIRSLLR REPSERLTAP EILLHPWFES VLEPGYIDSE IGTSDQIVPE YQEDSDISSF FC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase. The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain. Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA. Binds selectively the recognition sequence of CEBPA. Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner. Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain. Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity.
  • 基因功能参考文献：
    1. findings support the hypothesis that TRIB1 gene expression in human umbilical vein endothelial cells depends on the duration of intrauterine exposure to hyperglycaemia PMID: 29502537
    2. our study reveals that TRIB1 promotes CRC cell migration and invasion by up-regulating the expression of MMP-2 via the activation of FAK/Src and ERK pathways, knockdown of TRIB1 expression in CRC cells abolishes these effects. PMID: 28624785
    3. role of TRIB1 in cell cycle and survival that is mediated via the modulation of NFkappaB signaling. PMID: 28087598
    4. the co-operativity observed between MYC and TRIB1 in the absence of PML/RARA show that, outside of acute promyelocytic leukemia, gain of both genes may drive selection for trisomy 8. PMID: 27390356
    5. The crucial role of TRIB1 in cisplatin-induced enrichment of CSC and drug resistance was verified by knockdown TRIB1. Interestingly, cisplatin treatment also contributed to the increasement of HDAC, the interaction of TRIB1 with HDAC, and inactivation of p53. PMID: 28406482
    6. Trib1 formed a complex with pHDAC1. PMID: 26521947
    7. Studies indicate that tribbles homolog 1 (Drosophila) protein appear to be involved in some of the most common diseases, such as cancer, metabolic disease and hyperlipidaemia. PMID: 26517921
    8. Studies suggest that pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 and TRIB3 play roles in pathogenesis of rheumatoid arthritis (RA) and osteoarthritis. PMID: 26517922
    9. Studies indicate that the minor allele of a single nucleotide polymorphism (SNP, rs6982502) in the regulatory sequence reduces the activity of the tribbles homolog 1 (Drosophila) protein (TRIB1) promoter. PMID: 26517924
    10. Studies suggest that pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 and TRIB3 were involved in the pathogenesis of inflammation. PMID: 26517925
    11. Studies indicate that tribbles homolog 1 (Drosophila) protein (TRIB1) interacts with the master molecule of Tregs, forkhead box P3 (FOXP3), a transcription factor essential for Treg suppressive activity. PMID: 26517926
    12. Studies indicate that tribbles homolog 1 (Drosophila) protein (tribbles-1; TRIB1) is an important modulator of human energy metabolism and metabolic syndromes. PMID: 26517927
    13. Studies indicate that small molecules can reveal rate-limiting signalling outputs and functions of pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 and TRIB3 in cells and intact organisms, serving as guides for the development of new drugs. PMID: 26517930
    14. Studies indicate that overexpression of the wild-type tribbles homolog 1 (Drosophila) protein (Trib1) gene effectively induces leukaemia. PMID: 26517931
    15. Studies show that TRIB1 and TRIB2 are highly expressed in molecularly-defined sub-types of acute myeloid leukemia (AML). PMID: 26517933
    16. Studies show a remarkable reduction in tribbles 2 protein (Trib2) expression during oocyte maturation whereas tribbles 1 protein (Trib1) and tribbles 3 protein (Trib3) expression was significantly increased during this process. PMID: 26517934
    17. SNP rs17321515 associated with plasma triglycerides level and increasing risk of coronary heart disease in male Chinese Han population PMID: 25986010
    18. These studies indicated that SAP18 expression enhanced the recruitment of mSin3A in coordination with TRIB1 to MTTP regulatory elements and increased MTTP expression. PMID: 25921304
    19. TRB1 negatively regulates tumor-suppressor activity of p53 through p53 deacetylation PMID: 25832642
    20. trait-specific genetic risk scores are robustly associated with 10-yr changes in lipid levels and three individual SNPs in APOE, TRIB1, and APOA1 were strongly associated with 10-yr changes in lipid levels PMID: 24922540
    21. our study indicated that the TRIB1 gene, especially the rs2980879 polymorphism, is related to the development of pancreatic cancer in the Chinese Han population. PMID: 25117373
    22. genetic association studies in Japan: Data suggest SNPs in TRIB1 (rs2954021), GCKR (glucokinase regulatory protein, rs780094), and PNPLA3 (patatin-like phospholipase domain containing 3, rs738409) are associated with nonalcoholic fatty liver disease. PMID: 24785259
    23. TRIB1 was related to endoplasmic reticulum (ER) pathways. PMID: 24962028
    24. association with plasma triglyceride concentrations PMID: 24895164
    25. The TRIB1 rs2954029 is associated with serum triglyceride concentrations in Japanese community-dwelling women. PMID: 24910200
    26. These data suggested that the modulation of TRIB1 expression affects hepatic lipogenesis and glycogenesis through multiple molecular interactions. PMID: 24389359
    27. High TRIB1 expression is associated with prostate cancer. PMID: 24382668
    28. Trib1 acts as an activator of the MAPK pathway. PMID: 24161842
    29. We discuss the role of Tribs as central signaling mediators in different subtypes of acute leukemia and propose that inhibition of dysregulated Trib signaling may be therapeutically beneficial. PMID: 23550039
    30. tribbles-1 is a novel binding partner of Foxp3 in regulatory T cells PMID: 23417677
    31. Allelic variants of TRIB1 are independently involved in regulation of lipid metabolism and sleep. PMID: 22832862
    32. Studies indicate that three loci for lipid levels identified by GWAS has identified functional genes GALNT2, TRIB1, and SORT1, and a functional variant at SORT1. PMID: 22418572
    33. Studies indicate tribbles 1 and tribbles 3 as regulators of lipid level and disease susceptibility genes in metabolic syndrome and type 2 diabetes. PMID: 22274752
    34. TRIB1 R107L gain-of-function mutation is associated with acute megakaryocytic leukemia. PMID: 22294728
    35. The associations of TRIB1 rs17321515 SNP and serum lipid levels are different between the Mulao and Han populations. PMID: 22145581
    36. genetic association studies in Spain: A TRIB1 SNP (rs17321515) is associated with familial hypercholesterolemia. Smoking status and presence of arcus cornealis modulate effect of this TRIB1 SNP on plasma lipid levels in such patients. PMID: 20692138
    37. Data show no differences in triglyceride or total cholesterol levels in relation to any allelic variants of ANGPTL3, CILP2, or TRIB1 SNPs. PMID: 21691831
    38. TRIB1 polymorphisms were associated with increased risk of ischemic heart disease and myocardial infarction. PMID: 21071687
    39. Tribbles homolog 1 (Trib1) functions as a negative regulator of retinoic acid receptors. PMID: 21053424
    40. Trib1 may be a key mediator between the RTK-MAPK pathway and the C/EBP transcription factor in myeloid leukemogenesis. PMID: 20610816
    41. low trb-1 expression was associated with inactive C/EBPalpha PMID: 20005259
    42. Data show that SNPs associated with TG in normolipidemic samples, including APOA5, TRIB1, TBL2, GCKR, GALNT2 and ANGPTL3 were significantly associated with HLP types 2B, 3, 4 and 5. PMID: 19656773
    43. Tribbles controls both the extent and the specificity of MAPK kinase activation of MAPK PMID: 15299019
    44. used chemical shift perturbation experiments to show the possible SKIP binding interface on PPIL1 PMID: 16595688
    45. trb-1 has an important role in vascular smooth muscle cell biology PMID: 17452330

    显示更多

    收起更多

  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, Tribbles subfamily
  • 组织特异性：
    Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.
  • 数据库链接：

    HGNC: 16891

    OMIM: 609461

    KEGG: hsa:10221

    STRING: 9606.ENSP00000312150

    UniGene: Hs.444947