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  4. Recombinant Human Tripartite motif-containing protein 39 (TRIM39)

Recombinant Human Tripartite motif-containing protein 39 (TRIM39)

  • 中文名称：
    人TRIM39重组蛋白
  • 货号：
    CSB-YP881029HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TRIM39重组蛋白
  • 货号：
    CSB-EP881029HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TRIM39重组蛋白
  • 货号：
    CSB-EP881029HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TRIM39重组蛋白
  • 货号：
    CSB-BP881029HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TRIM39重组蛋白
  • 货号：
    CSB-MP881029HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TRIM39
  • Uniprot No.：
  • 别名：
    HGNC:10065; MGC32984; RING finger protein 23; RNF23; Testis abundant finger protein; Testis-abundant finger protein; TFP; TFP RING FINGER PROTEIN 23; TRI39_HUMAN; Trim39; TRIM39B; Tripartite motif containing 39; Tripartite motif-containing protein 39
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-518
  • 氨基酸序列
    MAETSLLEAG ASAASTAAAL ENLQVEASCS VCLEYLKEPV IIECGHNFCK ACITRWWEDL ERDFPCPVCR KTSRYRSLRP NRQLGSMVEI AKQLQAVKRK IRDESLCPQH HEALSLFCYE DQEAVCLICA ISHTHRAHTV VPLDDATQEY KEKLQKCLEP LEQKLQEITR CKSSEEKKPG ELKRLVESRR QQILREFEEL HRRLDEEQQV LLSRLEEEEQ DILQRLRENA AHLGDKRRDL AHLAAEVEGK CLQSGFEMLK DVKSTLEKNI PRKFGGSLST ICPRDHKALL GLVKEINRCE KVKTMEVTSV SIELEKNFSN FPRQYFALRK ILKQLIADVT LDPETAHPNL VLSEDRKSVK FVETRLRDLP DTPRRFTFYP CVLATEGFTS GRHYWEVEVG DKTHWAVGVC RDSVSRKGEL TPLPETGYWR VRLWNGDKYA ATTTPFTPLH IKVKPKRVGI FLDYEAGTLS FYNVTDRSHI YTFTDTFTEK LWPLFYPGIR AGRKNAAPLT IRPPTDWE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation.; Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation. Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner.
  • 基因功能参考文献：
    1. TRIM39 negatively regulates the NFkappaB signaling pathway possibly via stabilization of cactin. PMID: 26363554
    2. TRIM39R, but not TRIM39B, regulates type I interferon response PMID: 23707810
    3. TRIM39 has a role in regulating cell cycle progression and the balance between cytostasis and apoptosis after DNA damage via stabilizing p21 PMID: 23213251
    4. analysis of ubiquitylation of p53 by the APC/C inhibitor Trim39 PMID: 23213260
    5. these findings suggest that RNF39 and TRIM39 are involved in the etiology of Behcet's disease. PMID: 20875797
    6. Data suggest that TRIM39 can promote apoptosis signalling through stabilization of MOAP-1. PMID: 19100260

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  • 亚细胞定位：
    [Isoform 1]: Cytoplasm, cytosol. Mitochondrion. Nucleus.; [Isoform 2]: Nucleus.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.
  • 数据库链接：

    HGNC: 10065

    OMIM: 605700

    KEGG: hsa:56658

    STRING: 9606.ENSP00000365844

    UniGene: Hs.413493