Recombinant Human Trypsin-1 (PRSS1)

1. TF-FVIIa/trypsin-mediated PAR2 activation leads to enhanced MMP-2 expression in human breast cancer cells contributing to tumor progression. PMID: 29870887
2. report here for the first time a family from India that is positive for R122H mutation in the PRSS1 gene PMID: 29476405
3. Studied mutations in cationic trypsinogen (PRSS1) and serine protease inhibitor Kazal type 1 (SPINK1) and their association with alcoholic chronic pancreatitis (ACP) and idiopathic chronic pancreatitis. PMID: 29641165
4. Data indicate association between polymorphism rs10273639 of the PRSS1-PRSS2 locus and pancreatitis development. PMID: 27846138
5. SNP in the PRSS1-PRSS2-rs10273639 is associated with Chronic pancreatitis. PMID: 28913878
6. Gene mutations were present in PRSS1 in 26 patients with acute recurrent and chronic pancreatitis, SPINK1 in 23, CTRC in 3, and CPA1 in 5. In the 31 patients with mutations in SPINK1, CTRC, or CPA1, 16 (51.6%) had homozygous or heterozygous mutations with other mutations. PMID: 27409067
7. Results identified 3 new rare variants in the proximal promoter region of PRSS1 which along the known c.-30_-28delTCC do not seem to be a risk factors for chronic pancreatitis. PMID: 27432637
8. Early-onset pancreatitis is associated strongly with PRSS1 or CTRC mutations and family history of pancreatitis. PMID: 28502372
9. PRSS1 variant p.L104P exhibits a variety of phenotypic changes that can increase risk for chronic pancreatitis. Mutation-induced misfolding and associated ER stress are the dominant effects that support a direct pathogenic role in chronic pancreatitis. PMID: 26822915
10. Mutations in CFTR, SPINK1 or PRSS1 are present in one third of pediatric acute recurrent (ARP) or chronic (CP) pancreatitis with no other cause. PMID: 26692446
11. Three types of pathogenic PRSS1 variants was identified in 11 patients, including p.N29I (n=1), p.R122H (n=1), and p.G208A (n=9). PMID: 27578509
12. Mutations were found at the promoter and exon 3 of the PRSS1 in patients with pancreatic cancer. That is, five patients had c.410 C > T mutation causing p.Thr 137 Met, and three patients had c. -338 T >G mutation at the promoter of the PRSS1. In patients with PRSS1 mutations, serum trypsin was significantly higher than that in normal controls PMID: 26546433
13. These findings suggest that IL-1beta plays a key role in trypsin upregulation and has a pathological role in multiple organ failure in influenza virus infection. PMID: 27714503
14. Human anionic trypsinogen is controlled by CTRC in a manner that individual natural mutations are unlikely to increase stability enough to promote intra-pancreatic activation. PMID: 27129265
15. Association of PRSS1 polymorphism with idiopathic recurrent acute pancreatitis and idiopathic chronic pancreatitis. PMID: 26110235
16. Letter/Case Report: high penetrance of the PRSS1 A16V mutation caused by SPINK1 N34S and CFTR TG11-5T co-mutations associated with pancreatitis. PMID: 26658045
17. We did not find PRSS1 mutation in any patient. PMID: 25981744
18. In Israel, pediatric as well as adult recurrent acute pancreatitis and chronic pancreatitis are often associated with PRSS1, serine protease inhibitor Kazal type 1, chymotrypsin C, or Cystic Fibrosis Transmembrane Conductance Regulator mutations. PMID: 25383785
19. This study shows that PRSS1, SPINK1 and CFTR mutations do not play a role in alcoholic and idiopathic chronic pancreatitis patients. PMID: 25835118
20. N29T mutation associated with pancreatitis PMID: 26376395
21. Recombination events between members of the trypsinogen family can generate high-risk PRSS1 alleles. PMID: 25546417
22. the observations demonstrate that the tyrosyl sulfate in human trypsins interacts with the P2' position of the substrate-like inhibitor and this modification increases P2' selectivity towards basic side chains. PMID: 25010489
23. PRSS1 single nucleotide polymorphism is associated with alcoholic pancreatitis. PMID: 25253127
24. PRSS1 variants are associated with less disease relapse in autoimmune pancreatitis. PMID: 24909264
25. Two novel PRSS1 mutations were identified in Mexican patients with early onset idiopathic recurrent acute pancreatitis. PMID: 25206283
26. The -409 T/T genotype of PRSS1 gene was revealed to be a marker for predicting neotal sepsis, along with serum trypsin levels. PMID: 24777884
27. None of the selected 121 pancreatic cancer samples showed a pancreatitis-predisposing mutation in the PRSS1 gene. PMID: 25003218
28. expression of WT or mutant human PRSS1 in murine acinar cells induces apoptosis and is sufficient to promote spontaneous pancreatitis. PMID: 24722290
29. Using the optimal cutoffs, the sensitivity of the IRT/PAP strategy would not be inferior to that of IRT/DNA if identification of mild forms is not required. PMID: 24513262
30. PRSS1: IVS 2 +56_60 del CCCAG is a noval mutant which may contribute to AIP pathogenesis. PMID: 24236450
31. The p.G208A variant of PRSS1, previously only found in Asian patients, was found in 3 generations of a European family, one of whom had chronic pancreatitis. PMID: 24413785
32. the p.N43S mutation in the SPINK1 gene, accelerated the onset of HP in the presence of the p.R122H mutation in the CT gene. PMID: 24134754
33. Rare causative PRSS1 mutations account for 9.1% of the idiopathic chronic pancreatitis study group in 253 young French patients. PMID: 23951356
34. The trypsinogen to trypsin conformational switch modulates cleavage susceptibility of nick sites by altering both the thermodynamics and kinetics of cleavage to protect human cationic trypsin from premature degradation. PMID: 24403079
35. PRSS1 hereditary pancreatitis is characterized by progressive lipomatous atrophy of the pancreas. PMID: 24525505
36. No association of PRSS1 with pancreatic cancer is found. PMID: 23751316
37. D21A polymorphism in the PRSS1 gene seems to be a risk factor for hereditary chronic pancreatitis. PMID: 23864476
38. PRSS1 gene was significantly associated with total pancreatitis disease, both totally and separately PMID: 23801884
39. For pediatric ulcerative colitis patients who require surgery, the immunopositivity of Tryp-1 at diagnosis is lower when compared to that of patients with a more benign disease course. PMID: 23745029
40. Autoimmune pancreatitis may be related to PRSS1 gene mutations. PMID: 23745036
41. Trypsin-1 and trypsin-2 appear to have a function in the degradation of vitreous type II collagen. PMID: 23882137
42. A kindred from Venezuela, South America with the PRSS1 R122H variant. PMID: 23474566
43. Even in the absence of chymotrypsin C, trypsinogen activation peptide mutants autoactivated at markedly increased rates. PMID: 23601753
44. Case Report: suggest involvement of PRSS1 mutations in familial solid pseudopapillary pancreatic tumors. PMID: 22722260
45. Frequencies of CFTR variants p.R75Q, p.I148T, 5T-allele and p.E528E were comparable in patients and controls. We identified 103 CFTR variants, which represents a 2.7-fold risk increase (p<0.0001). PMID: 22427236
46. Two associations with alcoholic pancreatitis at genome-wide significance were identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. PMID: 23143602
47. Data show that among the 2 mutations in the PRSS1 gene, only the N29I mutation was found in 1 (1.7%) of 58 patients with AP, in the heterozygous state. PMID: 22699143
48. hereditary pancreatitis is caused by CTRC-dependent dysregulation of cationic trypsinogen autoactivation, which results in elevated trypsin levels in the pancreas. PMID: 22539344
49. All of the heterozygote patients with a combination of CFTR and SPINK1 or PRSS1 mutations had chronic pancreatitis. PMID: 22094894
50. Mutations of PRSS1 gene may be an important factor of pancreatic cancer. PMID: 22088471

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HGNC: 9475

OMIM: 167800

KEGG: hsa:5644

STRING: 9606.ENSP00000308720

UniGene: Hs.382212