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  4. Recombinant Human Tuberoinfundibular peptide of 39 residues (PTH2)

Recombinant Human Tuberoinfundibular peptide of 39 residues (PTH2)

  • 中文名称：
    人PTH2重组蛋白
  • 货号：
    CSB-YP842634HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PTH2重组蛋白
  • 货号：
    CSB-EP842634HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PTH2重组蛋白
  • 货号：
    CSB-EP842634HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PTH2重组蛋白
  • 货号：
    CSB-BP842634HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PTH2重组蛋白
  • 货号：
    CSB-MP842634HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PTH2
  • Uniprot No.：
  • 别名：
    PTH2; TIP39; TIPF39; Tuberoinfundibular peptide of 39 residues; TIP39; Parathyroid hormone 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    62-100
  • 氨基酸序列
    SLALADDAA FRERARLLAA LERRHWLNSY MHKLLVLDAP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.
  • 基因功能参考文献：
    1. modulator of endoplasmic reticulum calcium signalling PMID: 28094886
    2. Bit1 promotes TGF-beta2 induced alpha-SMA expression and acts as an positive regulator of EMT. PMID: 27122244
    3. The results demonstrate that TIP39 and the PTH2R are expressed in the brain of primates in locations that suggest involvement in regulation of fear, anxiety, reproductive behaviors, release of pituitary hormones, and nociception. PMID: 19401215
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Parathyroid hormone family
  • 组织特异性：
    Highly expressed in fetal and adult brain, cerebellum and trachea. Weakly expressed in spinal cord, fetal liver, kidney and heart.
  • 数据库链接：

    HGNC: 30828

    OMIM: 608386

    KEGG: hsa:113091

    STRING: 9606.ENSP00000270631

    UniGene: Hs.339845