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  4. Recombinant Human Tubulin beta-4B chain (TUBB4B)

Recombinant Human Tubulin beta-4B chain (TUBB4B)

  • 中文名称：
    人TUBB4B重组蛋白
  • 货号：
    CSB-YP025322HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TUBB4B重组蛋白
  • 货号：
    CSB-EP025322HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TUBB4B重组蛋白
  • 货号：
    CSB-EP025322HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TUBB4B重组蛋白
  • 货号：
    CSB-BP025322HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TUBB4B重组蛋白
  • 货号：
    CSB-MP025322HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    bA506K6.1; beta 2 tubulin; Beta2; class II beta tubulin isotype; class IIa beta-tubulin; class IIb beta-tubulin; Class IVb beta tubulin; dJ40E16.7; DKFZp566F223; FLJ98847; M(beta)2; MGC8685; OTTHUMP00000015956; OTTHUMP00000015964; TBB4B_HUMAN; TUBB 2; TUBB 2A; TUBB 2C; TUBB; TUBB PARALOG; TUBB2; TUBB2A; TUBB2B; TUBB2C; Tubb4b; Tubulin beta 2; Tubulin beta 2 chain; Tubulin beta 2A; Tubulin beta 2A chain; Tubulin beta 2B; Tubulin beta 2B chain; Tubulin beta 2C; Tubulin beta polypeptide; Tubulin beta polypeptide 2; Tubulin beta polypeptide paralog; Tubulin beta-2 chain; Tubulin beta-2C chain; Tubulin beta-4B chain; tubulin, beta 2A class IIa; tubulin, beta 2B class IIb; tubulin, beta 4B class IVb; Tubulin, beta, class IVB; Tubulin, beta-4B
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-445
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • 基因功能参考文献：
    1. nuclear beta(II)-tubulin can modulate Notch signaling through interaction with notch1 receptor intracellular domain in cancer cells PMID: 15548702
    2. The s identified TUBB4B mutations as the cause of a previously unreported autosomal-dominant syndrome manifesting as early-onset and severe photoreceptor and cochlear cell loss. PMID: 29198720
    3. The results od this study found that betaI-tubulin protein expression was decreased in the anterior cingulate cortex and increased in the dorsolateral prefrontal cortex, but not changed in superior temporal gyrus or hippocampus in schizophrenia. PMID: 22264600
    4. Data suggest that increased expression of hnRNP A1, Ezrin, tubulin beta-2C and Annexin A1 in SLNMM indicate a significantly elevated early colorectal cancer metastasis. PMID: 20872967
    5. Studies show that BFBTS bound and modified beta-tubulin at residue Cys12, forming beta-tubulin-SS-fluorobenzyl. PMID: 19996274
    6. transformation may lead to localization of beta(II)-tubulin in cell nuclei, serving an as yet unknown function, and that nuclear beta(II) may be a useful marker for detection of tumor cells PMID: 12037579
    7. Normal and tumor breast tissues, before chemotherapy or radiation treatment, have broad distributions of beta-tubulin isotypes; furthermore, beta class II tubulin predominates in most breast tissues. PMID: 12927047
    8. Annexin II and beta(2)-tubulin down-regulation is important in nasopharyngeal carcinoma formation and may represent potential targets for further investigations. PMID: 18384219

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tubulin family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 20771

    OMIM: 602660

    KEGG: hsa:10383

    STRING: 9606.ENSP00000341289

    UniGene: Hs.433615