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  4. Recombinant Human Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog (UQCC)

Recombinant Human Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog (UQCC)

  • 中文名称：
    人UQCC1重组蛋白
  • 货号：
    CSB-YP882113HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人UQCC1重组蛋白
  • 货号：
    CSB-EP882113HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人UQCC1重组蛋白
  • 货号：
    CSB-EP882113HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人UQCC1重组蛋白
  • 货号：
    CSB-BP882113HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人UQCC1重组蛋白
  • 货号：
    CSB-MP882113HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    UQCC1
  • Uniprot No.：
  • 别名：
    UQCC1; BZFB; C20orf44; UQCC; Ubiquinol-cytochrome-c reductase complex assembly factor 1; Basic FGF-repressed Zic-binding protein; bFGF-repressed Zic-binding protein; bFZb; Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-299
  • 氨基酸序列
    MALLVRVLRN QTSISQWVPV CSRLIPVSPT QGQGDRALSR TSQWPQMSQS RACGGSEQIP GIDIQLNRKY HTTRKLSTTK DSPQPVEEKV GAFTKIIEAM GFTGPLKYSK WKIKIAALRM YTSCVEKTDF EEFFLRCQMP DTFNSWFLIT LLHVWMCLVR MKQEGRSGKY MCRIIVHFMW EDVQQRGRVM GVNPYILKKN MILMTNHFYA AILGYDEGIL SDDHGLAAAL WRTFFNRKCE DPRHLELLVE YVRKQIQYLD SMNGEDLLLT GEVSWRPLVE KNPQSILKPH SPTYNDEGL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Involved in cytochrome b translation and/or stability.
  • 基因功能参考文献：
    1. Single nucleotide polymorphism in UQCC is associated with developmental dysplasia of the hip. PMID: 25848760
    2. UQCC3 is reduced in cells depleted for the complex III assembly factors UQCC1 and UQCC2. Conversely, absence of UQCC3 in patient cells does not affect UQCC1 and UQCC2. PMID: 25008109
    3. This work provides insight into human complex III assembly by establishing that UQCC1 and UQCC2 are complex III assembly factors participating in cytochrome b biogenesis. PMID: 24385928
    4. study identified a novel locus, i.e., the UQCC gene, for spine BS variation in humans. Future functional studies will contribute to elucidating the mechanisms by which UQCC regulates bone growth and development PMID: 23207799
    5. Data show that high serum VEGF levels are closely related to the activation status of the VEGFR2/KDR receptor in cancer cells, indicating a stimulatory effect of serum VEGF on the VEGF pathway contributing to tumor progression. PMID: 21208810
    6. Ca2+ homeostasis modulation enhances the amenability of L444P glucosylcerebrosidase to proteostasis regulation in patient-derived fibroblasts. PMID: 21043486
    7. These data suggest that HLX may function to balance attractive with repulsive vessel guidance by up-regulating UNC5B and to down-modulate sprouting under normoxic conditions. PMID: 21224470
    8. High VEGF is associated with peripheral T-cell lymphoma. PMID: 21077742
    9. Current and potential anticancer drugs targeting members of the UHRF1 complex including epigenetic modifiers. PMID: 21110828
    10. GPC3 was significantly more often and more strongly expressed in HCCs (72%) than in FLCs (17%). PMID: 20444731
    11. Data show that a significant increase in plasma SDF-1alpha, and an immediate decrease in plasma VEGF and FGF levels after chemotherapy. PMID: 20072657
    12. This paper describes the cloning of the human UQCC gene. PMID: 11118897
    13. The majority of tumours showed strong p16, p21, p27, pRb and cyclin D1 staining and little or no p53 expression. Tumours harbouring dysplasia were significantly more likely to be p53-positive and exhibit up-regulated p21 and p27 PMID: 19863319

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  • 亚细胞定位：
    Mitochondrion inner membrane. Cytoplasmic vesicle.
  • 蛋白家族：
    CBP3 family
  • 数据库链接：

    HGNC: 15891

    OMIM: 611797

    KEGG: hsa:55245

    STRING: 9606.ENSP00000363506

    UniGene: Hs.726290