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  4. Recombinant Human Ubiquitin-conjugating enzyme E2 Z (UBE2Z)

Recombinant Human Ubiquitin-conjugating enzyme E2 Z (UBE2Z)

  • 中文名称：
    人UBE2Z重组蛋白
  • 货号：
    CSB-YP875692HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人UBE2Z重组蛋白
  • 货号：
    CSB-EP875692HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人UBE2Z重组蛋白
  • 货号：
    CSB-EP875692HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人UBE2Z重组蛋白
  • 货号：
    CSB-BP875692HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人UBE2Z重组蛋白
  • 货号：
    CSB-MP875692HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    FLJ13855; GC17P044341; HOYS7; Uba6 specific E2 conjugating enzyme 1; UBA6 specific enzyme E2; Uba6-specific E2 conjugating enzyme 1; UBE2Z; UBE2Z_HUMAN; Ubiquitin carrier protein Z; Ubiquitin conjugating enzyme E2 Z; Ubiquitin conjugating enzyme E2Z; Ubiquitin protein ligase Z; Ubiquitin-conjugating enzyme E2 Z; Ubiquitin-protein ligase Z; Use1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-354
  • 氨基酸序列
    MAESPTEEAA TAGAGAAGPG ASSVAGVVGV SGSGGGFGPP FLPDVWAAAA AAGGAGGPGS GLAPLPGLPP SAAAHGAALL SHWDPTLSSD WDGERTAPQC LLRIKRDIMS IYKEPPPGMF VVPDTVDMTK IHALITGPFD TPYEGGFFLF VFRCPPDYPI HPPRVKLMTT GNNTVRFNPN FYRNGKVCLS ILGTWTGPAW SPAQSISSVL ISIQSLMTEN PYHNEPGFEQ ERHPGDSKNY NECIRHETIR VAVCDMMEGK CPCPEPLRGV MEKSFLEYYD FYEVACKDRL HLQGQTMQDP FGEKRGHFDY QSLLMRLGLI RQKVLERLHN ENAEMDSDSS SSGTETDLHG SLRV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.
  • 基因功能参考文献：
    1. The SNP rs46522 in UBE2Z gene is associated with the risk of coronary Artery disease in the individuals of Chinese Han descent with type 2 diabetes and is of synergistic effect with Body mass index. PMID: 28840129
    2. we found that USE1 proteins were frequently overexpressed in human lung cancer. Furthermore, overexpression of USE1 promoted in vivo and in vitro proliferation, migration, and invasion. PMID: 28376205
    3. Association of UBE2Z single nucleotide polymorphism rs46522 with the susceptibility to coronary artery disease in an Iranian population. PMID: 26602883
    4. UBE2Z was widely expressed in human tissues and is located on chromosome 17q21. PMID: 17160626
    5. In tissue culture cells, Uba6 is required for charging a previously uncharacterized Uba6-specific E2 (Use1), whereas Ube1 is required for charging the cell-cycle E2s Cdc34A and Cdc34B PMID: 17597759

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Ubiquitin-conjugating enzyme family
  • 组织特异性：
    Widely expressed. Highly in placenta, pancreas, spleen and testis.
  • 数据库链接：

    HGNC: 25847

    OMIM: 611362

    KEGG: hsa:65264

    STRING: 9606.ENSP00000354201

    UniGene: Hs.514297