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  4. Recombinant Human Urotensin-2 (UTS2)

Recombinant Human Urotensin-2 (UTS2)

  • 货号：
    CSB-YP025771HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP025771HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP025771HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP025771HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP025771HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    UTS2
  • Uniprot No.：
  • 别名：
    PRO1068; U-II; UCN2; UII; Urotensin 2 preproprotein isoform a; Urotensin 2 preproprotein isoform b; Urotensin II; Urotensin-2; UTS2; UTS2_HUMAN; UTSII
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    114-124
  • 氨基酸序列
    ETPDCFW KYCV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Highly potent vasoconstrictor.
  • 基因功能参考文献：
    1. polymorphisms of the UTS2 gene are not risk factors for migraine in our sample of Turkish migraine patients. PMID: 28686849
    2. Host genetics influences UTS2 levels, which may contribute to inflammation and cardiovascular damage in KD PMID: 28753597
    3. Opposite actions of urotensin II and relaxin-2 on cellular expression of fibronectin in renal fibrosis PMID: 28613403
    4. Ser89Asn (S89N) polymorphisms of the UTS2 gene were associated with hypertension in a Chinese female population. Additionally, we demonstrated that genotype Asn89Asn was associated with left ventricular posterior wall thickness for subjects with hypertension and cardiac hypertrophy in a Chinese female population. PMID: 27941008
    5. Children and adolescents with CKD, particularly those who are not on hemodialysis (HD) and renal transplantation, have significantly higher levels of UII than healthy subjects. UII levels increase significantly at the end of the HD session. The presence of metabolic acidosis affects significantly plasma UII levels. PMID: 28359257
    6. UII/GPR14 signaling was involved in the DSS-induced colonic inflammation and its inhibition may serve as a potential therapeutic target, which may be associated with the NF-kappaB signaling pathway. PMID: 27600191
    7. Ser89Asn polymorphisms of the UTS2 gene are significantly associated with atrial fibrillation in the Chinese population. Additionally, we demonstrated that genotype Met21Met may have a potential beneficial role in atrial fibrillation. PMID: 26811505
    8. Serum urotensin II levels were significantly lower in hemodialysis patients compared to healthy subjects. PMID: 26870964
    9. expression of UII is associated with ERS in patients with SPE. Our results indicate that UII may trigger ERS in placental trophoblastic cells in patients with preeclampsia. PMID: 25880595
    10. Our study suggests that U-II may play a role in migraine pathogenesis; also Thr21Met polymorphism was associated with the risk of migraine disease. PMID: 27090416
    11. Used transgenic rabbits as a model to study macrophage-specific expressing human UII (hUII) and studied the role of autocrine UII in the development of atherosclerosis. PMID: 26640798
    12. Urotensin II-increased reactive oxygen species production via the NADPH oxidase pathway is partially associated with activation of the PI3K/Akt and ERK cascades PMID: 26658815
    13. provide evidence that, in glioma cells, homogeneous concentration of UII allowed translocation of Galpha13 to the UT receptor at the plasma membrane and increased actin stress fibers, lamellipodia formation and vinculin-stained focal adhesions PMID: 25597409
    14. enzyme-linked immunosorbent assay (ELISA) and restriction fragment length polymorphism analysis were used to evaluate plasma levels of urotensin-II and Thr21Met and Ser89Asn polymorphisms of UTS2 gene in breast cancer patients. PMID: 25604143
    15. Urotensin II can induce the proliferation of BEL-7402 cells via the urotensin receptor mediated PKC/ERK/p38 MAPK signaling pathways. PMID: 25514221
    16. Urotensin-II induces activating transcription factor 3 (ATF3) at both mRNA and protein levels. PMID: 25268131
    17. The significantly high Urotensin-II levels in the knee synovial fluid of osteoarthritic patients than in non-osteoarthritic patients. PMID: 24468547
    18. This study revealed high plasma U-II level might be accepted as a risk factor for in-stent restenosis with bare metal stent PMID: 24831766
    19. Urotensin II seems be associated with menopausal status, and extra-nodal and lymphatic invasion in breast cancer patients. PMID: 25112588
    20. Study suggests that soluble CD40 ligand and urotensin II likely play a role in the pathogenesis of slow coronary flow. PMID: 25648034
    21. Plasma urotensin II levels are elevated in patients with acute coronary syndrome. PMID: 24642358
    22. U-II induces IL-8 expression in human umbilical vein endothelial cells via p38 mitogen-activated protein kinase and extracellular signal-regulated kinase signaling pathways. PMID: 24587311
    23. U-II level was higher in schizophrenia patients than in controls. PMID: 24552634
    24. results indicated that urotensin II might be an independent risk factor for essential hypertension. PMID: 24339964
    25. Elevation or urotensin II in the serum of preeclampsia patients could be corrected to the severity and/or progression of the disease. The urotensin genotype frequency between patients and control groups showed a significant difference. PMID: 25134283
    26. family-based analysis of association between blood pressure, glomerular filtration and genes of the urotensin-II pathway (urotensin-II, urotensin-II related peptide, urotensin-II receptor) saturated with 28 tagging single nucleotide polymorphisms PMID: 24391740
    27. mutation associated with pre-eclampsia risk PMID: 23905608
    28. Serum urotensin II levels were higher in patients with non-dipper hypertension than in patients with dipper hypertension (204 [106-533] vs. 140 [96-309]. There was a positive correlation between total systolic blood pressure and serum urotensin II levels. PMID: 23301552
    29. Data suggest that both urotensin II (UTS2) and C-reactive protein (CRP) are elevated in sera of subjects with polycystic ovary syndrome; UTS2 may play role in physiopathology of insulin resistance and increased cardiovascular events in such patients. PMID: 23981122
    30. Thr21Met (T21M) but not Ser89Asn (S89N) polymorphisms of the urotensin-II (UTS-II) gene are associated with Behcet's disease in a Turkish population. PMID: 23333481
    31. Data suggest that aortic urotensin II (UII) is increased in diabetes-associated atherosclerosis in humans and mice; diabetes-associated plaque development is attenuated by UII/UII receptor antagonism in in vitro (human) and in vivo (mouse) settings. PMID: 23344731
    32. Urotensin II was expressed in the lung of pulmonary hypertension patients with congenital heart disease. PMID: 23158820
    33. Associations between Thr21Met and Ser89Asn polymorphisms in the UTS2 gene and diabetic retinopathy strongly suggest that these polymorphisms may be an important a risk factor in Caucasians. PMID: 22587369
    34. U-II elicited penile erection through eNOS activation PMID: 22319601
    35. High urotensin II levels in recipients of kidney transplants could be drug-related (immunosuppressive drugs) and may be of practical importance that may be used to improve the long-term outcome of the patients PMID: 22098077
    36. Data show an association between Thr21Met, but not Ser89Asn, in the urotensin II gene and systemic sclerosis. PMID: 22045841
    37. Increased UT-II, sTM, and vWF in ankylosing spondylitis patient sera regardless of treatment and disease activity suggest an increased tendency for atherosclerosis. PMID: 21556780
    38. In Korean women, the common UTS-II 143 G/A polymorphism is unlikely to have an association with the risk of preeclampsia. PMID: 21623998
    39. polymorphisms in UTS2 and PER3 may have roles in glucose homeostasis and diabetes PMID: 21559414
    40. U-II levels in serum are significantly increased in children with chronic liver disease (portal hypertension or liver cirrhosis) compared with healthy controls; magnitude of U-II increase is related to severity and long-term liver disease outcomes. PMID: 21694541
    41. Urotensin-II may have a vital role in systemic sclerosis. PMID: 21274584
    42. the precursor undergoes pH- and Ca(2+)-dependent conformational and stability changes; ProUII has a stable tertiary structure at pH 5.5 in presence of Ca(2+) and is correctly cleaved in these conditions by prohormone convertases. PMID: 21605557
    43. circulating urotensin II may participate in the worsening course of some type 2 diabetes mellitus patients. PMID: 20695946
    44. This study suggest that UTS2 single gene (S89N) polymorphism is not associated with pre-eclampsia. PMID: 20653105
    45. elevated in plasma of pre-eclamptic women PMID: 20017703
    46. The expression of urotensin 2 is increased in airways of rat asthmatic models and of patients with asthma. PMID: 17045018
    47. These findings suggest that the intrahepatic UII/UT system has an important pathophysiological role in cirrhosis and portal hypertension. PMID: 20428787
    48. Endothelin-1 and urotensin-II levels are increased in plasma of patients with coronary heart disease. PMID: 20339975
    49. The U-II, in addition to the well known role in the regulation of cardiovascular function, also exert a specific angiogenic activity. PMID: 19362580
    50. Urocortin II exhibits motor suppressive and delayed anxiolytic-like effects, suggesting a time-dependent role in the regulation of stress-related behavior. PMID: 12088848

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Urotensin-2 family
  • 组织特异性：
    Brain specific.
  • 数据库链接：

    HGNC: 12636

    OMIM: 604097

    KEGG: hsa:10911

    UniGene: Hs.715862