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  4. Recombinant Human WAS/WASL-interacting protein family member 2 (WIPF2)

Recombinant Human WAS/WASL-interacting protein family member 2 (WIPF2)

  • 中文名称：
    人WIPF2重组蛋白
  • 货号：
    CSB-YP823478HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人WIPF2重组蛋白
  • 货号：
    CSB-EP823478HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人WIPF2重组蛋白
  • 货号：
    CSB-EP823478HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人WIPF2重组蛋白
  • 货号：
    CSB-BP823478HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人WIPF2重组蛋白
  • 货号：
    CSB-MP823478HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    WIPF2; WICH; WIRE; PP10631; WAS/WASL-interacting protein family member 2; WASP-interacting protein-related protein; WIP- and CR16-homologous protein; WIP-related protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-440
  • 氨基酸序列
    MPIPPPPPPP PGPPPPPTFH QANTEQPKLS RDEQRGRGAL LQDICKGTKL KKVTNINDRS APILEKPKGS SGGYGSGGAA LQPKGGLFQG GVLKLRPVGA KDGSENLAGK PALQIPSSRA AAPRPPVSAA SGRPQDDTDS SRASLPELPR MQRPSLPDLS RPNTTSSTGM KHSSSAPPPP PPGRRANAPP TPLPMHSSKA PAYNREKPLP PTPGQRLHPG REGPPAPPPV KPPPSPVNIR TGPSGQSLAP PPPPYRQPPG VPNGPSSPTN ESAPELPQRH NSLHRKTPGP VRGLAPPPPT SASPSLLSNR PPPPARDPPS RGAAPPPPPP VIRNGARDAP PPPPPYRMHG SEPPSRGKPP PPPSRTPAGP PPPPPPPLRN GHRDSITTVR SFLDDFESKY SFHPVEDFPA PEEYKHFQRI YPSKTNRAAR GAPPLPPILR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.
  • 基因功能参考文献：
    1. Study provides evidence that WIP and WIRE contribute to breast cancer cell invasiveness through coordinated roles. WIP seems necessary for the assembly of invasive protrusions, whereas WIRE regulates their maturation, which leads to matrix degradation. PMID: 27009365
    2. Data indicate that the reduced vimentin expression in response to EPHB4, WIPF2 and MTHFD2 silencing was observed at mRNA and protein levels. PMID: 23295955
    3. The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor PMID: 12213210
  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Note=Localized to stress fibers and bundles of actin filaments.
  • 蛋白家族：
    Verprolin family
  • 组织特异性：
    Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta.
  • 数据库链接：

    HGNC: 30923

    OMIM: 609692

    KEGG: hsa:147179

    STRING: 9606.ENSP00000320924

    UniGene: Hs.421622