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  4. Recombinant Human Zinc finger MYND domain-containing protein 10 (ZMYND10)

Recombinant Human Zinc finger MYND domain-containing protein 10 (ZMYND10)

  • 货号：
    CSB-YP026511HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP026511HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP026511HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP026511HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP026511HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZMYND10
  • Uniprot No.：
  • 别名：
    ZMYND10; BLU; LUCA12.4; Zinc finger MYND domain-containing protein 10; Protein BLu
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-440
  • 氨基酸序列
    MGDLELLLPG EAEVLVRGLR SFPLREMGSE GWNQQHENLE KLNMQAILDA TVSQGEPIQE LLVTHGKVPT LVEELIAVEM WKQKVFPVFC RVEDFKPQNT FPIYMVVHHE ASIINLLETV FFHKEVCESA EDTVLDLVDY CHRKLTLLVA QSGCGGPPEG EGSQDSNPMQ ELQKQAELME FEIALKALSV LRYITDCVDS LSLSTLSRML STHNLPCLLV ELLEHSPWSR REGGKLQQFE GSRWHTVAPS EQQKLSKLDG QVWIALYNLL LSPEAQARYC LTSFAKGRLL KLRAFLTDTL LDQLPNLAHL QSFLAHLTLT ETQPPKKDLV LEQIPEIWER LERENRGKWQ AIAKHQLQHV FSPSEQDLRL QARRWAETYR LDVLEAVAPE RPRCAYCSAE ASKRCSRCQN EWYCCRECQV KHWEKHGKTC VLAAQGDRAK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
  • 基因功能参考文献：
    1. BLU suppressed tumor formation by strengthening the antitumor immunity. PMID: 28029652
    2. A novel frameshift mutation (c.367delC) in ZMYND10, unique for Slavic primary ciliary dyskinesia population (PCD), was found in homozygous state in two unrelated PCD patients. PMID: 26824761
    3. Data identified a novel functional BLU promoter that was regulated by Sp1. Furthermore, the hypermethylated -39 CpG in BLU proximal promoter directly reduced its binding with Sp1. PMID: 26043875
    4. Data show that the zinc finger MYND-type containing 10 protein BLU gene may be one of the key components of signaling networks controlling tumor microenvironment and angiogenesis. PMID: 25347745
    5. Mutations in ZMYND10 cause primary ciliary dyskinesia. PMID: 23891471
    6. Methylation of BLU could be a potential prognostic biomarker for advanced ovarian serous carcinoma PMID: 23329649
    7. Data indicate that BLU could suppress the growth of ovarian carcinoma cells through down-regulation of Bcl-2 protein. PMID: 23628417
    8. these data indicated that methylation of the BLU promoter region is an early event during hepatocellular carcinoma development. PMID: 22766745
    9. The N-terminal of BLU was observed to interact with the C-terminal of SMEK1, a regulatory subunit of protein phosphatase 4. Furthermore, we determined the binding domains that are required for interaction between BLU and sMEK1. The N-terminal of BLU was observed to interact with the C-terminal of sMEK1. PMID: 22349239
    10. BLU may play a substantial role in the development and etiology of myelodysplastic syndrome. PMID: 22246278
    11. A significant correlation between BLU methylation and loss of expression of BLU was observed in gastric, colorectal and pancreatic cancers. PMID: 20394502
    12. These data suggest a significant role for epigenetic inactivation of BLU in the pathogenesis of common human cancers and that methylation inactivation of BLU occurs independent of RASSF1A in SCLC and neuroblastoma tumours. PMID: 12629521
    13. BLU may be one of the critical tumor suppressor genes on chromosome 3p21.3 involved in the development of nasopharyngeal carcinoma PMID: 12794757
    14. BLU, a candidate tumor suppressor gene, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma. PMID: 15122337
    15. Smoking under age 18 is an independent risk for BLU hypermethylation, thus identifying a molecular alteration related to the epidemiologic effect of teenage smoking as a lung cancer risk. PMID: 15540210
    16. ninety-two percent of glioma tumor samples were methylated for RASSF1A, 30%-57% for BLU and 47% for MGMT, suggesting promoter methylation of these genes to be a common event in glioma tumorigenesis PMID: 18616639

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  • 相关疾病：
    Ciliary dyskinesia, primary, 22 (CILD22)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Apical cell membrane. Dynein axonemal particle.
  • 蛋白家族：
    ZMYND10 family
  • 数据库链接：

    HGNC: 19412

    OMIM: 607070

    KEGG: hsa:51364

    STRING: 9606.ENSP00000231749

    UniGene: Hs.526735