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  4. Recombinant Human Zinc finger protein 143 (ZNF143)

Recombinant Human Zinc finger protein 143 (ZNF143)

  • 中文名称：
    人ZNF143重组蛋白
  • 货号：
    CSB-YP026542HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ZNF143重组蛋白
  • 货号：
    CSB-EP026542HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ZNF143重组蛋白
  • 货号：
    CSB-EP026542HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ZNF143重组蛋白
  • 货号：
    CSB-BP026542HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ZNF143重组蛋白
  • 货号：
    CSB-MP026542HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZNF143
  • Uniprot No.：
  • 别名：
    ZNF143; SBF; STAF; Zinc finger protein 143; SPH-binding factor; Selenocysteine tRNA gene transcription-activating factor; hStaf
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-638
  • 氨基酸序列
    MLLAQINRDS QGMTEFPGGG MEAQHVTLCL TEAVTVADGD NLENMEGVSL QAVTLADGST AYIQHNSKDA KLIDGQVIQL EDGSAAYVQH VPIPKSTGDS LRLEDGQAVQ LEDGTTAFIH HTSKDSYDQS ALQAVQLEDG TTAYIHHAVQ VPQSDTILAI QADGTVAGLH TGDATIDPDT ISALEQYAAK VSIDGSESVA GTGMIGENEQ EKKMQIVLQG HATRVTAKSQ QSGEKAFRCE YDGCGKLYTT AHHLKVHERS HTGDRPYQCE HAGCGKAFAT GYGLKSHVRT HTGEKPYRCS EDNCTKSFKT SGDLQKHIRT HTGERPFKCP FEGCGRSFTT SNIRKVHVRT HTGERPYYCT EPGCGRAFAS ATNYKNHVRI HTGEKPYVCT VPGCDKRFTE YSSLYKHHVV HTHSKPYNCN HCGKTYKQIS TLAMHKRTAH NDTEPIEEEQ EAFFEPPPGQ GEDVLKGSQI TYVTGVEGDD VVSTQVATVT QSGLSQQVTL ISQDGTQHVN ISQADMQAIG NTITMVTQDG TPITVPAHDA VISSAGTHSV AMVTAEGTEG EQVAIVAQDL AAFHTASSEM GHQQHSHHLV TTETRPLTLV ATSNGTQIAV QLGEQPSLEE AIRIASRIQQ GETPGLDD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8.
  • 基因功能参考文献：
    1. The zinc finger, ZNF143, binds to the CCCAGCAG site in the CEBPA promoter. PMID: 28900037
    2. The inhibition of ZNF143 activity by small molecules induced tumor regression. PMID: 28192620
    3. Data show that zinc finger protein 143 (ZNF143) promotes epithelial-mesenchymal transition (EMT) through regulating PI3K/AKT pathway in gastric cancer (GC) cells. PMID: 27449034
    4. The results show that as an important partner of CTCF, ZNF143 helps establishing the conserved chromatin structure by cooperating with cohesin. PMID: 27414788
    5. ZNF143 is directly recruited to the promoter of genes engage in chromatin interactions, where it binds to its DNA recognition sequence. PMID: 25645053
    6. THAP11, ZNF143, and HCF-1 form a mutually dependent complex on chromatin, which is independent of E2F occupancy. PMID: 25437553
    7. ZNF143 expresses different 3'-untranslated regions (3'-UTR) as a result of alternative polyadenylation PMID: 24952353
    8. High zinc-finger protein 143 is associated with cancer cell migration and invasion through ZEB1 and E-cadherin in colon cancer. PMID: 24009065
    9. ZNF143 upregulated GPX1 activity and protecting cells from oxidative damage. PMID: 23152058
    10. GIPC is involved in IGF-1 signaling leading to ZNF143 expression through the regulation of ROS production, which may play a role for colon cancer tumorigenesis. PMID: 21909943
    11. The data provides the demonstration that hStaf/ZNF143 is indeed a transcription factor controlling the expression of divergent protein-protein and protein-non-coding RNA gene pairs. PMID: 21177654
    12. data suggest that IGF-1 induces ZNF143 expression in cancer cells via PI3-kinase and reactive oxygen species generation during receptor internalization. PMID: 20733350
    13. ZNF143 might be a master regulator of the cell cycle. PMID: 20860770
    14. These results demonstrated that the Staf binding site functioned as the basal transcriptional activator of the S phase-specific gene ESCO2, but other mechanisms are required for cell cycle-dependent expression. PMID: 20116366
    15. human interferon regulatory factor-3 (IRF-3) gene promoter contains a functional SPH element that is bound by SBF/Staf in vitro and in transfected cells PMID: 11724783
    16. ZNF143 plays a key role in basal and tissue-specific expression of transaldolase and regulation of the metabolic network controlling cell survival and differentiation PMID: 14702349
    17. interplay of ZNF143, p73 and ZNF143 target genes is involved in DNA repair gene expression and cisplatin resistance PMID: 17297437
    18. A pivotal role for transcription factor hStaf/ZNF143 in the expression of the BUB1B gene was demonstrated. PMID: 17478512
    19. Transcription factor ZNF143 is required for expression of TFAM gene. PMID: 17707600
    20. Staf activates U6 transcription from a preassembled chromatin template in vitro and associates with several proteins linked to chromatin modification, among them chromodomain-helicase-DNA binding protein 8 (CHD8). PMID: 17938208

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    GLI C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed in all tissues tested, with the strongest expression in ovary.
  • 数据库链接：

    HGNC: 12928

    OMIM: 603433

    KEGG: hsa:7702

    STRING: 9606.ENSP00000379847

    UniGene: Hs.523471