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  4. Recombinant Human Zinc finger protein 304 (ZNF304)

Recombinant Human Zinc finger protein 304 (ZNF304)

  • 货号：
    CSB-YP026655HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP026655HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP026655HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP026655HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP026655HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZNF304
  • Uniprot No.：
  • 别名：
    MGC129703; MGC129704; Zinc finger protein 304; ZN304_HUMAN; ZNF 304; ZNF304
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-659
  • 氨基酸序列
    MAAAVLMDRV QSCVTFEDVF VYFSREEWEL LEEAQRFLYR DVMLENFALV ATLGFWCEAE HEAPSEQSVS VEGVSQVRTA ESGLFQKAHP CEMCDPLLKD ILHLAEHQGS HLTQKLCTRG LCRRRFSFSA NFYQHQKQHN GENCFRGDDG GASFVKSCTV HMLGRSFTCR EEGMDLPDSS GLFQHQTTYN RVSPCRRTEC MESFPHSSSL RQHQGDYDGQ MLFSCGDEGK AFLDTFTLLD SQMTHAEVRP FRCLPCGNVF KEKSALINHR KIHSGEISHV CKECGKAFIH LHHLKMHQKF HTGKRHYTCS ECGKAFSRKD TLVQHQRVHT GERSYDCSEC GKAYSRSSHL VQHQRIHTGE RPYKCNKCGK AFSRKDTLVQ HQRFHTGERP YECSECGKFF SQSSHLIEHW RIHTGARPYE CIECGKFFSH NSSLIKHRRV HTGARSYVCS KCGKAFGCKD TLVQHQIIHT GARPYECSEC GKAFSRKDTL VQHQKIHTGE RPYECGECGK FFSHSSNLIV HQRIHTGAKP YECNECGKCF SHNSSLILHQ RVHTGARPYV CSECGKAYIS SSHLVQHKKV HTGARPYECS ECGKFFSRNS GLILHQRVHT GEKPYVCSEC GKAYSRSSHL VRHQKAHTGE RAHECNSFGG PLAASLKLV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as transcriptional regulator and plays a role in gene silencing. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites. Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways. Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression. Promotes angiogenesis. Promotes tumor growth.
  • 基因功能参考文献：
    1. transcriptional regulator of beta1 integrin, promotes cancer cell survival and protects against anoikis in ovarian cancer PMID: 26081979
    2. Identification of ZNF304, by AU-motif-directed display method and characterization of its role in lymphocyte activation PMID: 12051768
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed in undifferentiated embryonic stem cells (ESCs). Expressed strongly in colorectal cancers cells (CRCs). Expressed strongly in ovarian carcinoma (OC) tumor cell lines compared to non-transformed ovarian epithelial cells (at protein level). Expres
  • 数据库链接：

    HGNC: 13505

    OMIM: 613840

    KEGG: hsa:57343

    STRING: 9606.ENSP00000282286

    UniGene: Hs.287374