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  4. Recombinant Human Zinc finger protein 711 (ZNF711)

Recombinant Human Zinc finger protein 711 (ZNF711)

  • 货号：
    CSB-YP026980HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP026980HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP026980HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP026980HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP026980HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZNF711
  • Uniprot No.：
  • 别名：
    CMPX1; dJ75N13.1; MRX97; Zfp711; Zinc finger protein 6 (CMPX1); Zinc finger protein 6; Zinc finger protein 711; ZN711; ZN711_HUMAN; ZNF4; ZNF5; ZNF6; ZNF711
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-761
  • 氨基酸序列
    MDSGGGSLGL HTPDSRMAHT MIMQDFVAGM AGTAHIDGDH IVVSVPEAVL VSDVVTDDGI TLDHGLAAEV VHGPDIITET DVVTEGVIVP EAVLEADVAI EEDLEEDDGD HILTSELITE TVRVPEQVFV ADLVTGPNGH LEHVVQDCVS GVDSPTMVSE EVLVTNSDTE TVIQAAGGVP GSTVTIKTED DDDDDVKSTS EDYLMISLDD VGEKLEHMGN TPLKIGSDGS QEDAKEDGFG SEVIKVYIFK AEAEDDVEIG GTEIVTESEY TSGHSVAGVL DQSRMQREKM VYMAVKDSSQ EEDDIRDERR VSRRYEDCQA SGNTLDSALE SRSSTAAQYL QICDGINTNK VLKQKAKKRR RGETRQWQTA VIIGPDGQPL TVYPCHICTK KFKSRGFLKR HMKNHPDHLM RKKYQCTDCD FTTNKKVSFH NHLESHKLIN KVDKTHEFTE YTRRYREASP LSSNKLILRD KEPKMHKCKY CDYETAEQGL LNRHLLAVHS KNFPHVCVEC GKGFRHPSEL KKHMRTHTGE KPYQCQYCIF RCADQSNLKT HIKSKHGNNL PYKCEHCPQA FGDERELQRH LDLFQGHKTH QCPHCDHKST NSSDLKRHII SVHTKDFPHK CEVCDKGFHR PSELKKHSDI HKGRKIHQCR HCDFKTSDPF ILSGHILSVH TKDQPLKCKR CKRGFRQQNE LKKHMKTHTG RKIYQCEYCE YSTTDASGFK RHVISIHTKD YPHRCEFCKK GFRRPSEKNQ HIMRHHKEAL M
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C.
  • 基因功能参考文献：
    1. Two large four-generation families have been described with a total of 11 males affected with intellectual disability (ID) caused by mutations in ZNF711, all present with mild to moderate ID and poor speech accompanied by autistic features and mild facial dysmorphisms, suggesting that ZNF711mutations cause non-syndromic ID. PMID: 27993705
    2. The KCTD5/cullin3 complex stabilizes ZNF711 transcription factor. PMID: 26188516
    3. A total of six novel and 11 known single nucleotide polymorphisms were identified. Further studies are warranted to analyze the candidate genes at Xq11.1-q21.33. PMID: 21384559
    4. A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation is reported. PMID: 20346720
  • 相关疾病：
    Mental retardation, X-linked 97 (MRX97)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed in neural tissues.
  • 数据库链接：

    HGNC: 13128

    OMIM: 300803

    KEGG: hsa:7552

    STRING: 9606.ENSP00000276123

    UniGene: Hs.326801