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  4. Recombinant Human Zinc finger protein PLAGL2 (PLAGL2)

Recombinant Human Zinc finger protein PLAGL2 (PLAGL2)

  • 中文名称：
    人PLAGL2重组蛋白
  • 货号：
    CSB-YP891980HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PLAGL2重组蛋白
  • 货号：
    CSB-EP891980HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PLAGL2重组蛋白
  • 货号：
    CSB-EP891980HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PLAGL2重组蛋白
  • 货号：
    CSB-BP891980HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PLAGL2重组蛋白
  • 货号：
    CSB-MP891980HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PLAGL2
  • Uniprot No.：
  • 别名：
    C2H2 type zinc finger protein ; KIAA0198; PLAGL2; PLAL2_HUMAN; Pleiomorphic adenoma gene-like 2; Pleiomorphic adenoma-like protein 2; Zinc finger protein PLAGL2; ZNF900
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-496
  • 氨基酸序列
    MTTFFTSVPP WIQDAKQEEE VGWKLVPRPR GREAESQVKC QCEISGTPFS NGEKLRPHSL PQPEQRPYSC PQLHCGKAFA SKYKLYRHMA THSAQKPHQC MYCDKMFHRK DHLRNHLQTH DPNKEALHCS ECGKNYNTKL GYRRHLAMHA ASSGDLSCKV CLQTFESTQA LLEHLKAHSR RVAGGAKEKK HPCDHCDRRF YTRKDVRRHL VVHTGRKDFL CQYCAQRFGR KDHLTRHVKK SHSQELLKIK TEPVDMLGLL SCSSTVSVKE ELSPVLCMAS RDVMGTKAFP GMLPMGMYGA HIPTMPSTGV PHSLVHNTLP MGMSYPLESS PISSPAQLPP KYQLGSTSYL PDKLPKVEVD SFLAELPGSL SLSSAEPQPA SPQPAAAAAL LDEALLAKSP ANLSEALCAA NVDFSHLLGF LPLNLPPCNP PGATGGLVMG YSQAEAQPLL TTLQAQPQDS PGAGGPLNFG PLHSLPPVFT SGLSSTTLPR FHQAFQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Shows weak transcriptional activatory activity.
  • 基因功能参考文献：
    1. overexpression of miR-449a inhibited the expression of PLAGL2 significantly and the knockdown of PLAGL2 expression inhibited the breast cancer cell proliferation and metastasis PMID: 29653747
    2. increased expression correlates to prostate cancer progression following radical prostatectomy and may serve as novel poor prognostic marker PMID: 27537362
    3. Our findings indicated that PLAGL2 might be a very upstream key molecule regulating Epithelial-mesenchymal transition involved in Wnt/bcatenin signaling pathway in Colorectal adenocarcinoma PMID: 28259923
    4. Our findings indicate that PALGL2 serves as a tumor oncoprotein in the development and progression of colorectal cancer PMID: 25031728
    5. PLAGL2 expression induces lamellipodia formation and disruption of stress fiber formation. PMID: 24675530
    6. PLAGL2 regulate cell cycle and apoptosis via activation of the p53 family member, p73, in human promonocytic U937 cells. PMID: 22076304
    7. Transcriptome analysis revealed that these differentiation-suppressive activities are attributable in part to PLAGL2 modulation of Wnt/beta-catenin signaling PMID: 20478531
    8. The data identify PC2 as a novel PLAGL2-binding protein and important mediator of PLAGL2 transactivation. PMID: 20025940
    9. PLAGL2 may modulate SP-C expression during lung development. PMID: 15361364
    10. Coexpression of Tip60 and PLAGL2 completely abolishes the sumoylation of PLAGL2. PMID: 17551969
    11. Nuclear PLAGL2 occupied and transactivated the endogenous SP-C promoter in hypoxic lung cells.These results further suggest that PLAGL2 is an oxidative stress responding regulator in lung cells. PMID: 17618602
    12. This study thus uncovers a novel function of PLAGL2 as an oncoprotein through regulating the stability of Pirh2. PMID: 17950244
    13. These data suggests that Ubc9 can function as a co-factor of PLAGL2, uncoupling from its enzymatic activity, to mediate PLAGL2 interactive SP-C promoter activity. PMID: 18655774
    14. Increased cell injury and/or death could be caused directly by the upregulation of bNip3, a preapoptotic molecule that dimerizes with Bcl-2, or indirectly by the aberrant expression of SP-C-induced endoplasmic reticulum stress in epithelial cells. PMID: 19574421

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 数据库链接：

    HGNC: 9047

    OMIM: 604866

    KEGG: hsa:5326

    STRING: 9606.ENSP00000246229

    UniGene: Hs.154104