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  4. Recombinant Human Zona pellucida sperm-binding protein 3 (ZP3), partial

Recombinant Human Zona pellucida sperm-binding protein 3 (ZP3), partial

  • 中文名称：
    人ZP3重组蛋白
  • 货号：
    CSB-RP145354h
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    ZP3
  • Uniprot No.：
  • 别名：
    HUMZP3; Processed zona pellucida sperm-binding protein 3; Sperm receptor; zona pellucida glycoprotein 3 (sperm receptor); Zona pellucida glycoprotein 3; zona pellucida glycoprotein 3A (sperm receptor); Zona pellucida glycoprotein ZP3; Zona pellucida protein C; Zona pellucida sperm binding protein 3 precursor; Zp-3; ZP3 372; ZP3 424; ZP3 474; ZP3; ZP3_HUMAN; ZP3A; ZP3A/ZP3B; ZP3B; ZPC
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 来源：
    E.coli
  • 分子量：
    63.0kDa
  • 表达区域：
    23-346aa
  • 氨基酸序列
    QPLWLLQGGASHPETSVQPVLVECQEATLMVMVSKDLFGTGKLIRAADLTLGPEACEPLVSMDTEDVVRFEVGLHECGNSMQVTDDALVYSTFLLHDPRPVGNLSIVRTNRAEIPIECRYPRQGNVSSQAILPTWLPFRTTVFSEEKLTFSLRLMEENWNAEKRSPTFHLGDAAHLQAEIHTGSHVPLRLFVDHCVATPTPDQNASPYHTIVDFHGCLVDGLTDASSAFKVPRPGPDTLQFTVDVFHFANDSRNMIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGSADICQCCNKGDCGTPSHSRRQPHVMSQWSRS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal GST-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
  • 基因功能参考文献：
    1. The zona pellucida-3 (ZP3) protein plays a pivotal role in oocyte and gamete development. PMID: 30341457
    2. The oocyte ZP3 expression was the main predictor of the fertilization capacity. PMID: 28204536
    3. Missense Mutation in ZP3 gene is associated with Empty Follicle Syndrome and Female Infertility. PMID: 28886344
    4. Epididymal CRISP1 mediates sperm-zona pellucida binding through its interaction with ZP3. PMID: 24334245
    5. observed sequence variations in exons of ZP3 gene in women with infertility of unknown origin who exhibit abnormal zona pellucida; sperm-ovum interactions appear relatively normal in these patients [CASE REPORTS] PMID: 22889493
    6. Eggs expressing glycoprotein huZP3, derived from transgenic mice, bind murine but not human sperm, implying that huZP3 acquires the same O-glycans as native mZP3. PMID: 14673092
    7. human and mouse ZP3 proteins are quite similar, and alternative explanations of taxon-specific sperm binding warrant exploration PMID: 15379548
    8. Binding sites for recombinant zona pellucida C (ZPC) glycoprotein are located both at the N- and C-terminus of proacrosin PMID: 15950651
    9. Peptides rhuZP3a22 approximately 176 and rhuZP3b177 approximately 348 have a role similar to human ZP3. The mechanism of the response to the peptides involves influx of calcium, the G protein pathway, and a T-type calcium channel. PMID: 17192598
    10. may have a role in the development of primordial follicle before zona pellucida formation PMID: 18502569
    11. induces acrosome reactions which are protein kinase-C, protein tyrosine kinase, T-type Ca2+ channels, and extracellular Ca2+ dependent PMID: 18667750
    12. a significant decrease in acrosomal exocytosis mediated by both recombinant human ZP3 (p<0.005) and ZP4 (p<0.005) was observed in presence of the immune sera PMID: 19004505
    13. The functional activity of human ZP3 resides in its C-terminal domain. PMID: 19246320

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  • 相关疾病：
    Oocyte maturation defect 3 (OOMD3)
  • 亚细胞定位：
    [Processed zona pellucida sperm-binding protein 3]: Zona pellucida.; Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    ZP domain family, ZPC subfamily
  • 组织特异性：
    Expressed in oocytes (at protein level).
  • 数据库链接：

    HGNC: 13189

    OMIM: 182889

    KEGG: hsa:7784

    STRING: 9606.ENSP00000378326

    UniGene: Hs.656137