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  4. Recombinant Human adenovirus A serotype 12 Early E2A DNA-binding protein (DBP)

Recombinant Human adenovirus A serotype 12 Early E2A DNA-binding protein (DBP)

  • 货号：
    CSB-YP356272HIB
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP356272HIB
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP356272HIB-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP356272HIB
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP356272HIB
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    DBPDNA-binding protein; DBP; Early 2A protein; Early E2A DNA-binding protein
  • 种属：
    Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-484
  • 氨基酸序列
    MASNQHSQRE RTPDRSAQPP PPKMGRYFLD SESEEELEAV PLPPKKKVKK SMAAIPLSPE SAEEEEAEPP RAVLGVMGFS MPPVRIMHHA DGSQSFQKME TRQVHVLKAS AQNSDENEKN VVVVRNPASQ PLVSAWEKGM EAMAMLMEKY HVDHDERATF RFLPDQGSVY KKICTTWLNE EKRGLQLTFS SQKTFQELMG RFLQGYMQAY AGVQQNSWEP TGCCVWEHKC TEREGELRCL HGMEMVRKEH LVEMDVTSES GQRALKENPS KAKVAQNRWG RNVVQIKNDD ARCCFHDVGC GNNSFSGKSC GLFYSEGMKA QIAFRQIEAF MLADYPHMRH GQKRLLMPVR CECLNKQDGL PRMGRQLCKI TPFNLSNVDN IDINEVTDPG ALASIKYPCL LVFQCANPVY RNARGNAGPN CDFKISAPDV MGALQLVRQL WGENFDGSPP RLVIPEFKWH QRLQYRNISL PTNHGDCREE PFDF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in the elongation phase of viral strand displacement replication by unwinding the template in an ATP-independent fashion, employing its capacity to form multimers. Also enhances the rate of initiation. Released from template upon second strand synthesis. Assembles in complex with viral pTP, viral pol, host NFIA and host POU2F1/OCT1 on viral origin of replication. Covers the whole ssDNA genome during synthesis. The complementary strand synthesis induces its relese from DNA template. May inhibit cellular transcription mediated by the interaction between host SRCAP and CBP.
  • 基因功能参考文献：
    1. results indicate that E2A-PBX1 cooperates with additional gene alterations to develop acute lymphoblastic leukemia; among them, enhanced expression of ZNF521 may play a clinically relevant role in E2A fusion genes to develop B-lineage ALL PMID: 27088431
  • 亚细胞定位：
    Host nucleus.
  • 蛋白家族：
    Adenoviridae E2A DNA-binding protein family
  • 数据库链接：

    KEGG: vg:1460850