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  4. Recombinant Human herpesvirus 1 DNA polymerase processivity factor (UL42)

Recombinant Human herpesvirus 1 DNA polymerase processivity factor (UL42)

  • 货号：
    CSB-YP318722HWY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP318722HWY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP318722HWY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP318722HWY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP318722HWY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    UL42
  • Uniprot No.：
  • 别名：
    UL42; DNA polymerase processivity factor; DNA-binding protein UL42; Polymerase accessory protein; PAP
  • 种属：
    Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-488
  • 氨基酸序列
    MTDSPGGVAP ASPVEDASDA SLGQPEEGAP CQVVLQGAEL NGILQAFAPL RTSLLDSLLV MGDRGILIHN TIFGEQVFLP LEHSQFSRYR WRGPTAAFLS LVDQKRSLLS VFRANQYPDL RRVELAITGQ APFRTLVQRI WTTTSDGEAV ELASETLMKR ELTSFVVLVP QGTPDVQLRL TRPQLTKVLN ATGADSATPT TFELGVNGKF SVFTTSTCVT FAAREEGVSS STSTQVQILS NALTKAGQAA ANAKTVYGEN THRTFSVVVD DCSMRAVLRR LQVGGGTLKF FLTTPVPSLC VTATGPNAVS AVFLLKPQKI CLDWLGHSQG SPSAGSSASR ASGSEPTDSQ DSASDAVSHG DPEDLDGAAR AGEAGALHAC PMPSSTTRVT PTTKRGRSGG EDARADTALK KPKTGSPTAP PPADPVPLDT EDDSDAADGT AARPAAPDAR SGSRYACYFR DLPTGEASPG AFSAFRGGPQ TPYGFGFP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an essential role in viral DNA replication by acting as the polymerase accessory subunit. Associates with the viral polymerase to increase its processivity and forms high-affinity direct interactions with DNA. Facilitates the origin-binding protein UL9 loading onto DNA thus increasing its ability to assemble into a functional complex capable of unwinding duplex DNA.
  • 基因功能参考文献：
    1. UL42 plays a remarkably essential roleduring coupled activity; in the absence of UL42, the polymerase still binds at the replication fork but in a manner that is incompetent with respect to coupled helicase-polymerase activity. PMID: 28505413
    2. Data suggest that UL30/UL42 is a single bifunctional protein exhibiting both polymerase and exonuclease activities; UL30/UL42 also exhibits two completely independent active sites for these activities. PMID: 26836009
  • 亚细胞定位：
    Host nucleus.
  • 蛋白家族：
    Herpesviridae DNA polymerase processivity factor family
  • 数据库链接：

    KEGG: vg:24271471