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  4. Recombinant Human respiratory syncytial virus B Non-structural protein 1 (1C)

Recombinant Human respiratory syncytial virus B Non-structural protein 1 (1C)

  • 中文名称：
    Recombinant Human respiratory syncytial virus B Non-structural protein 1(1C),Yeast
  • 货号：
    CSB-YP522092HXK
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human respiratory syncytial virus B Non-structural protein 1(1C),Yeast
  • 货号：
    CSB-EP522092HXK
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human respiratory syncytial virus B Non-structural protein 1(1C),Yeast
  • 货号：
    CSB-EP522092HXK-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human respiratory syncytial virus B Non-structural protein 1(1C),Yeast
  • 货号：
    CSB-BP522092HXK
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human respiratory syncytial virus B Non-structural protein 1(1C),Yeast
  • 货号：
    CSB-MP522092HXK
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    1C
  • Uniprot No.：
  • 别名：
    1C; NS1; Non-structural protein 1; Non-structural protein 1C
  • 种属：
    Human respiratory syncytial virus B (strain B1)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-139
  • 氨基酸序列
    MGCNSLSMIK VRLQNLFDND EVALLKITCY TDKLILLTNA LAKAAIHTIK LNGIVFIHVI TSSEVCPDNN IVVKSNFTTM PILQNGGYIW ELIELTHCSQ LNGLMDDNCE IKFSKRLSDS VMTNYMNQIS DLLGLDLNS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a major role in antagonizing the type I IFN-mediated antiviral response by degrading or inhibiting multiple cellular factors required for either IFN induction or response pathways. Acts cooperatively with NS2 to repress activation and nuclear translocation of host IFN-regulatory factor IRF3. Also disrupts the association of IRF3 with CREBBP. Interacts with host mitochondrial-associated membrane (MAM) MAVS and prevents the interaction with DDX58/RIG-I. Interacts with TRIM25 to suppress TRIM25-mediated DDX58 ubiquitination and thereby DDX58-MAVS interaction. Together with NS2, participates in the proteasomal degradation of host STAT2, IRF3, IRF7, TBK1 and DDX58/RIG-I through a NS-degradasome involving CUL2 and Elongin-C. The degradasome requires an intact mitochondrial MAVS. Decreases the levels of host TRAF3 and IKBKE/IKK-epsilon. As functions other than disruptions of the type I IFN-mediated antiviral signaling pathways, induces host SOCS1 and SOCS3 expression. Suppresses premature apoptosis by an NF-kappa-B-dependent, interferon-independent mechanism and thus facilitates virus growth. Additionally, NS1 may serve some inhibitory role in viral transcription and RNA replication. Suppresses proliferation and activation of host CD103+ CD8+ cytotoxic T-lymphocytes and Th17 helper T-lymphocytes.
  • 基因功能参考文献：
    1. NS1 interacts with KLF6 and modulates miR-24 expression and TGF-beta, which facilitates respiratory syncytial virus replication. PMID: 26253191
    2. Conformational Heterogeneity Determined by Folding and Oligomer Assembly Routes of the Interferon Response Inhibitor NS1 Protein PMID: 26237467
    3. Respiratory syncytial virus NS1 upregulates SOCS1 expression in a RIG-I- and TLR3-independent pathway, to inhibit STAT2 phosphorylation. PMID: 24480984
    4. Over-expression of the RSV NS1 impairs glucocorticoid receptor-induced transactivation. PMID: 24418538
    5. The s show that recombinant NS1 and NS2, expressed in lung epithelial A549 cells, can form homo- as well as heteromers and localize in mitochondria and cell nucleus. PMID: 21795342

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  • 亚细胞定位：
    Host cytoplasm. Host mitochondrion. Host nucleus.
  • 蛋白家族：
    Pneumovirus non-structural protein 1 family
  • 数据库链接：

    KEGG: vg:1489818