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  4. Recombinant Macaca fuscata fuscata Aldo-keto reductase family 1 member C4 (AKR1C4)

Recombinant Macaca fuscata fuscata Aldo-keto reductase family 1 member C4 (AKR1C4)

  • 中文名称：
    Recombinant Macaca fuscata fuscata Aldo-keto reductase family 1 member C4(AKR1C4),Yeast
  • 货号：
    CSB-YP846488MMX
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Macaca fuscata fuscata Aldo-keto reductase family 1 member C4(AKR1C4),Yeast
  • 货号：
    CSB-EP846488MMX
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Macaca fuscata fuscata Aldo-keto reductase family 1 member C4(AKR1C4),Yeast
  • 货号：
    CSB-EP846488MMX-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Macaca fuscata fuscata Aldo-keto reductase family 1 member C4(AKR1C4),Yeast
  • 货号：
    CSB-BP846488MMX
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Macaca fuscata fuscata Aldo-keto reductase family 1 member C4(AKR1C4),Yeast
  • 货号：
    CSB-MP846488MMX
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    AKR1C4
  • Uniprot No.：
  • 别名：
    AKR1C4Aldo-keto reductase family 1 member C4; EC 1.1.1.-; 3-alpha-HSD1; 3-alpha-hydroxysteroid dehydrogenase type I; EC 1.1.1.357; Chlordecone reductase; CDR; EC 1.1.1.225; Dihydrodiol dehydrogenase 4; DD-4; DD4
  • 种属：
    Macaca fuscata fuscata (Japanese macaque)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-323
  • 氨基酸序列
    MDPKYQRVAL NDGHFMPVLG FGSYAPPEVP RNRVVEVTKL AIEAGFRHID SAYLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCTFF RPQLVQPALE SSLKKLQLDY VDLYLIHFPM ALKPGETPLP KDENGKVMFD TVDLCAIWEA MEKCKDAGLA KSIGVSNFNR RQLEMILNNP GLKYKPVCNQ VECHPYLNQS KLLDFCKSKD IVLVAHSALG TQRHKLWVDQ NSPALLEDPV LCALAKKHKR SPALIALRYQ LQRGVVVLAK SYNEQRIREN VQVFEFQLTS EDMKVLDDLN RNFRYVVMDF LVDHPDYPFS DEY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Liver specific enzyme that acts as NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain. Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH. Acts preferentially as a 3-alpha-hydroxysteroid dehydrogenase (HSD) with a subsidiary 3-beta-HSD activity. Catalyzes efficiently the transformation of the potent androgen 5-alpha-dihydrotestosterone (5alpha-DHT or 17beta-hydroxy-5alpha-androstan-3-one) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Catalyzes the reduction of estrone into 17beta-estradiol but with low efficiency. Metabolizes a broad spectrum of natural and synthetic therapeutic steroid and plays an important role in metabolism of androgens, estrogens, progestereone and conjugated steroids. Catalyzes the biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leading to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Aldo/keto reductase family
  • 组织特异性：
    High expression in liver. Also expressed in kidney.