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  4. Recombinant Macropus eugenii Steroidogenic factor 1 (NR5A1)

Recombinant Macropus eugenii Steroidogenic factor 1 (NR5A1)

  • 中文名称：
    Recombinant Macropus eugenii Steroidogenic factor 1(NR5A1),Yeast
  • 货号：
    CSB-YP846501MPE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Macropus eugenii Steroidogenic factor 1(NR5A1),Yeast
  • 货号：
    CSB-EP846501MPE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Macropus eugenii Steroidogenic factor 1(NR5A1),Yeast
  • 货号：
    CSB-EP846501MPE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Macropus eugenii Steroidogenic factor 1(NR5A1),Yeast
  • 货号：
    CSB-BP846501MPE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Macropus eugenii Steroidogenic factor 1(NR5A1),Yeast
  • 货号：
    CSB-MP846501MPE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NR5A1
  • Uniprot No.：
  • 别名：
    NR5A1; SF1; Steroidogenic factor 1; SF-1; STF-1; Nuclear receptor subfamily 5 group A member 1
  • 种属：
    Macropus eugenii (Tammar wallaby)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-463
  • 氨基酸序列
    MDYSYDEDLD ELCPVCGDKV SGYHYGLLTC ESCKGFFKRT VQNNKHYTCT ESQNCKIDKT QRKRCPYCRF QKCLTVGMRL EAVRADRMRG GRNKFGPMYK RDRALKQQKK ALIRANGFKL ETGPSMGPPP QTDYPLAPAL HPGAKGLAPA PPAGPPGDYE RGPYGPPGVP MAVPTHGPLA GYLYPAFPGR AIKSEYPEPY ASPHEPAPPY GYPEPYPSGP GLPGVPELIL KLLQLEPDEG QLKARILACL QEPSKGRPDR PTPFGLMCKM ADQTLFSIVE WARSCVVFKE LEVADQMKLL QNCWSELLVF DHIYRQIQHG KEGSILLVTG QEVDLSTVAA QAGSLLHSLV LRAQDLVQQL HSLQVDRQEF VCLKFLILFS LDVKFLENHG LAKDAQEKAN SALLEYTMCH YPHCGDKFRQ LLLRLAEVRS LSMQAEEYLY HKHLGGEVPC NNLLIEMLHA KRT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family, NR5 subfamily
  • 组织特异性：
    Expressed in the pre-granulosa and Sertoli cells of the ovary and testis, respectively. In the testis it is also present in the interstitial cells. In the adult ovary it is expressed in the interstitial gland, and in the granulosa cells and theca interna