Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Meleagris gallopavo Beta-1 adrenergic receptor (ADRB1), partial

Recombinant Meleagris gallopavo Beta-1 adrenergic receptor (ADRB1), partial

  • 货号：
    CSB-YP001391MQV1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP001391MQV1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP001391MQV1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP001391MQV1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP001391MQV1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    ADRB1; Beta-1 adrenergic receptor; Beta-1 adrenoreceptor; Beta-1 adrenoceptor; Beta-T
  • 种属：
    Meleagris gallopavo (Common turkey)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. In dorsal pons neurons, involved in the regulation of sleep/wake behaviors.
  • 基因功能参考文献：
    1. In both sexes of Crollwitzer turkey hearts, the beta1-AR density decreased with age but significance was reached in male cardiac chambers. PMID: 29253207
    2. backbone NMR reveals allosteric signal transduction networks in the beta1-adrenergic receptor PMID: 26840483
    3. 2.1 A resolution structure of cyanopindolol-bound beta1-adrenoceptor identifies an intramembrane Na+ ion that stabilises the ligand-free receptor PMID: 24663151
    4. Monoclonal anti-beta1-adrenergic receptor antibodies activate G protein signaling in the absence of beta-arrestin recruitment PMID: 24253107
    5. Although the combination of mutations severely reduced the activation ability of ADRB1, the final crystallised receptor (beta36-m23) was still a functional receptor capable of binding agonists and antagonists and activating cellular agonist responses. PMID: 21547538
    6. 2.7 A resolution crystal structure of turkey beta(1)-adrenergic receptor in complex with the high-affinity antagonist cyanopindolol PMID: 18594507
    7. Molecular simulations of beta-1 AR show formation of an ionic lock, with the cytoplasmatic end of transmembrane (TM)6 helix approaching TM3 resulting in an equilibrium geometry that is stabilized by direct interaction of arginine and glutamate. PMID: 19378975
    8. The all-atom force-field energy function was used to calculate a stability score to detect stabilizing point mutations in G-protein coupled receptors. PMID: 20643076
    9. four crystal structures of the thermostabilized turkey beta(1)-adrenergic receptor bound to the full agonists carmoterol and isoprenaline and the partial agonists salbutamol and dobutamine PMID: 21228877

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Early endosome.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRB1 sub-subfamily
  • 数据库链接：

    KEGG: mgp:100303680

    STRING: 9103.ENSMGAP00000011521

    UniGene: Mga.4462