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  4. Recombinant Mesobuthus martensii Alpha-like toxin BmK-M1

Recombinant Mesobuthus martensii Alpha-like toxin BmK-M1

  • 中文名称：
    Recombinant Mesobuthus martensii Alpha-like toxin BmK-M1,Yeast
  • 货号：
    CSB-YP338276MRE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mesobuthus martensii Alpha-like toxin BmK-M1,Yeast
  • 货号：
    CSB-EP338276MRE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mesobuthus martensii Alpha-like toxin BmK-M1,Yeast
  • 货号：
    CSB-EP338276MRE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mesobuthus martensii Alpha-like toxin BmK-M1,Yeast
  • 货号：
    CSB-BP338276MRE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mesobuthus martensii Alpha-like toxin BmK-M1,Yeast
  • 货号：
    CSB-MP338276MRE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 别名：
    ; Alpha-like toxin BmK M1; BmK-M1; BmKM1; BmK-I; BmK I; BmKI; BmK1
  • 种属：
    Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-83
  • 氨基酸序列
    V RDAYIAKPHN CVYECARNEY CNDLCTKNGA KSGYCQWVGK YGNGCWCIEL PDNVPIRVPG KCH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels thereby blocking neuronal transmission. This toxin is active against both mammals and insects, and is classified as an alpha-like toxin. It is active on Nav1.2/SCN2A (EC(50)=139-252 nM), Nav1.3/SCN3A (EC(50)=565 nM), Nav1.4/SCN4A and Nav1.5/SCN5A (EC(50)=195-500 nM), Nav1.6/SCN8A (EC(50)=214 nM), and drosophila DmNav1 (EC(50)=30 nM). In mNav1.6/SCN8A, the toxin induces a large increase in both transient and persistent currents, which correlates with a prominent reduction in the fast component of inactivating current. In rNav1.2/SCN2A and rNav1.3/SCN3A, toxin-increased currents is much smaller. Moreover, the toxin only accelerates the slow inactivation development and delay recovery of mNav1.6/SCN8A through binding to the channel in the open state. Is 6-fold more toxic than BmK-M2. In vivo, intrahippocampal injection into rat induces epileptiform responses. In addition, intraplantar injection into rat induces spontaneous nociception and hyperalgesia.
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily
  • 组织特异性：
    Expressed by the venom gland.