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  4. Recombinant Mouse 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein (Ispd)

Recombinant Mouse 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein (Ispd)

  • 中文名称：
    小鼠Ispd重组蛋白
  • 货号：
    CSB-YP716257MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ispd重组蛋白
  • 货号：
    CSB-EP716257MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ispd重组蛋白
  • 货号：
    CSB-EP716257MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ispd重组蛋白
  • 货号：
    CSB-BP716257MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ispd重组蛋白
  • 货号：
    CSB-MP716257MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ispd
  • Uniprot No.：
  • 别名：
    Crppa; Ispd; D-ribitol-5-phosphate cytidylyltransferase; EC 2.7.7.40; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein; Isoprenoid synthase domain-containing protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-447
  • 氨基酸序列
    MEPGPCSRPA EPGHCVSGPA GAGSAFPESP LSVAGAEPGN RPGTVAAVLP AGGCGERMGV RTPKQFCRVL ERPLISYTLQ AMERVCWIKD IVVTVTGENM EAMRSIIQRY GHKRISLAEA GATRHRSIFN GLKALAEDQP DCKLTKPEVV IIHDAVRPFV EEDILLRVVL AAKEHGAAGA IRPLVSTVIS PSADGHLDHS LDRAKHRASE MPQAFLFDVI YEAYQQCSDF DLEFGTECLQ LALKYCHRKA KLVEGPPALW KVTYKQDLCA AEAMIKEKIS QEICVVMNTK DEESVGHLLE EALRKELNCM KITSTVMDHI GGDIRNFIEQ CYSFICVNVV SPDSQETRKL LRILEESSLP LLYPVVVVLV HCFDFTSVPL AQKMESLVWI RGLAKEVKER NILLSGLLLN YSQDEQKLQE SLGQSAAIIA ALVKERNSAL VGQLLVA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cytidylyltransferase required for protein O-linked mannosylation. Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate. CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively. Not Involved in dolichol production.
  • 基因功能参考文献：
    1. we show that activated NOTCH1 and ZMIZ1 collaborate to induce T-ALL in mice PMID: 23161489
    2. This study demonistrated that the axonal guidance defects observed in ispd mutant mice. PMID: 23217742
  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    IspD/TarI cytidylyltransferase family, IspD subfamily
  • 数据库链接：

    KEGG: mmu:75847

    STRING: 10090.ENSMUSP00000061646

    UniGene: Mm.261764