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  4. Recombinant Mouse ADM (Adm)

Recombinant Mouse ADM (Adm)

  • 货号：
    CSB-YP001370MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP001370MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP001370MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP001370MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP001370MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Adm
  • Uniprot No.：
  • 别名：
    Adm; ADM [Cleaved into: Adrenomedullin; AM); Proadrenomedullin N-20 terminal peptide; ProAM N-terminal 20 peptide; PAMP; ProAM-N20)]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    22-41
  • 氨基酸序列
    AGPDTPSQF RKKWNKWALS R
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    AM and PAMP are potent hypotensive and vasodilatator agents.
  • 基因功能参考文献：
    1. Up-regulated mRNA and protein levels of proadrenomedullin (ProADM) during acute myocardial infarction in mice and humans. PMID: 30166452
    2. AM is an important regulator of endothelial cell function, angiogenesis, tumorigenesis, and brain response to ischemia. PMID: 27640364
    3. The AM-RAMP2 system exerts crucial vasoprotective effects after vascular injury and could be a therapeutic target for the treatment of vascular diseases. PMID: 28324104
    4. Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3. PMID: 27553639
    5. Findings demonstrated that Adrenomedullin (AM) was produced by synovial fibroblasts and macrophages in inflamed synovial tissue and that increased levels of AM may exert anti-inflammatory effects on synovial macrophages. PMID: 28299347
    6. the paracrine/autocrine influence of AM in club cells subtly modulates their proliferation and spreading kinetics during lung epithelium recovery. PMID: 26661726
    7. vascular dysfunction was potentially augmented by a decrease in production of the pulmonary vasodilator adrenomedullin PMID: 26687815
    8. It was concluded that ADM may regulate chloride and fluid secretion from the seminal vesicle, which may affect the composition of the seminal plasma bathing the sperm and, hence, fertility. PMID: 24899577
    9. Estrogen-induced microRNAs are important for balancing cardiac Adm expression in female mice. PMID: 26582637
    10. These results indicate the AM-RAMP2 system works to protect nerve cells from both acute and chronic cerebral ischemia by maintaining cerebral blood flow suppressing oxidative stress, and in the case of chronic ischemia, enhancing capillary growth. PMID: 25252154
    11. Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis. PMID: 24123312
    12. It is a vasodiation factor and a essential factor for angiogenesis. PMID: 24813793
    13. The endogenous adrenomedullin gene exhibits an antioxidant action via the inhibition of NADPH oxidase probably by suppressing the local renin-angiotensin system. PMID: 23957015
    14. Hypoxia upregulates expression of the Notch ligand Dll4 and increases Notch signaling in a process requiring the vasoactive hormone adrenomedullin. PMID: 23379656
    15. Adrenomedullin-RAMP2 system is crucially involved in retinal angiogenesis. PMID: 23562442
    16. ADM signaling is involved in laser-induced CNV formation, because both an ADM antagonist and ADM mAb significantly inhibited it. PMID: 23520487
    17. Endogenous adrenomedullin is a key factor in secondary lymphedema pathogenesis and provides experimental in vivo evidence of an underlying germ-line genetic predisposition to developing this disorder. PMID: 23364478
    18. Fetal adrenomedullin, acting through calcitonin receptor-like receptor, serves as a trophoblast-derived factor critical for fetal placental vascularization. PMID: 23635772
    19. The AM-RAMP2 system is a key determinant of vascular integrity and homeostasis from prenatal stages through adulthood. PMID: 23355623
    20. Adrenomedullin is up-regulated in patients with pancreatic cancer and causes insulin resistance in beta cells and mice. PMID: 22960655
    21. A dosage range from approximately 10 to 200% of wild-type Adm expression did not affect Lewis lung carcinoma proliferation in vitro or in vivo, nor did it affect angiogenesis. Notably, the dosage of Adm markedly and significantly influenced tumor lymphangiogenesis. PMID: 23099649
    22. These data demonstrate that the adrenomedullin-RAMP2 system is essential for cardiac metabolism and homeostasis. PMID: 23297372
    23. CCL2 expression was upregulated in ADM(+/-) mice with concomitant increase in macrophage migration in the subretinal space. Additionally, the effect of ADM was abrogated in CCL2 knockout mice. PMID: 22841816
    24. A functional adrenomedullin signaling pathway is operating in the mouse retina. PMID: 22690112
    25. This study demonistrated that whole brain adrenomedullin mRNA expression was found to be increased at after hypoxia initiation. PMID: 22326698
    26. study reveals a novel mechanism that tumor-associated macrophages enhance angiogenesis and melanoma growth via adrenomedullin PMID: 21994414
    27. ADM-induced inactivation of GSK3beta by phosphorylation at Ser9, highly suggests that ADM could also exert its survival effect in osteoblast via components of the Wnt pathway PMID: 21826707
    28. Following middle cerebral artery permanent occlusion, there is a statistically significant infarct size increase AM-deficient animals, when compared to their wild type littermates PMID: 20854881
    29. adrenomedullin was found to upregulate VEGF and bFGF PMID: 21558971
    30. Importante role of AM in pain sensitivity, as it acts as a nociceotive modulator in spinal reflexes. PMID: 20858768
    31. Adrenomedullin is an important factor in regulating the proliferation and differentiation of adult NSPC and might be used to modulate stem cell renewal and fate in protocols destined to produce neural cells for regenerative therapies. PMID: 20182890
    32. The NO/sGC/cGMP pathway is central to the cytoprotective action of adrenomedullin against ischaemia-reperfusion injury. PMID: 19714395
    33. ADMR mediates the stimulatory effects of adrenomedullin on cancer cells and on endothelial and stellate cells within the tumor microenvironment PMID: 19847298
    34. endogenous AM plays a role in the physiological regulation of the vascular tone. AM is likely to protect renal tissues from ischemia/reperfusion injury PMID: 11934832
    35. AM may play a role in the regulation not only of cochlear hemodynamics but also of cochlear fluid dynamics PMID: 12037382
    36. adrenomedullin expression was decreased, and resistin expression increased, during adipocyte-differentiation of 3T3-L1 cells PMID: 12630810
    37. endogenous adrenomedullin plays a physiological role in the regulation of aortic tone. PMID: 12630815
    38. Analysis of adrenomedullin knockout mice suggest that adrenomedullin has a vascular protective role. PMID: 12667641
    39. AM plays significant roles in vascular regeneration, associated with PKA- and PI3K-dependent activation of Akt in endothelial cells, and possesses therapeutic potential for vascular injury and tissue ischemia PMID: 12782295
    40. Adrenomedullin upregulates muscarinic M2 receptor expression in cardiomyocytes during late differentiation stages. PMID: 12871842
    41. Endogenous adrenomedullin protects against intimal thickening and oxidative stress in injured femoral arteries. PMID: 14769703
    42. Endogenous AM exerts a protective effect against stress-induced cardiac hypertrophy via protein kinase C- and protein kinase A-dependent regulation of ERK activation. AM may thus represent a useful new tool for the treatment of cardiovascular disease. PMID: 14967720
    43. expression of adrenomedullin is reduced in tissues of the developing embryonic TGF-beta1 null mouse compared to the wildtype mouse PMID: 15005577
    44. Endogenous AM is a potential protective peptide against hypoxia-induced vascular remodeling, possibly through the suppression of ROS generation. PMID: 15096451
    45. AM can act as a protective peptide against insulin resistance via its intrinsic antioxidant effect. PMID: 15105383
    46. expression in the podocytes was upregulated by stimuli or condition relevant to podocyte injury, suggesting its potential role in podocyte pathophysiology PMID: 15781248
    47. Endogenous adrenomedullin in the brain may inhibit sympathetic activation through its antioxidant action. PMID: 15867131
    48. adrenomedullin may be repressed through the ADRE-AR in adipocytes PMID: 16376459
    49. UCN and AM prevent lethal endotoxemia by decreasing the local and systemic levels of a wide spectrum of inflammatory mediators, including cytokines, chemokines, and the acute phase protein serum amyloid A PMID: 16723707
    50. Data implicate both maternal and, to a lesser extent, embryonic levels of AM in the processes of implantation, placentation, and fetal growth.. PMID: 16981008

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Adrenomedullin family
  • 数据库链接：

    KEGG: mmu:11535

    STRING: 10090.ENSMUSP00000033054

    UniGene: Mm.1408