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  4. Recombinant Mouse Activating signal cointegrator 1 complex subunit 1 (Ascc1)

Recombinant Mouse Activating signal cointegrator 1 complex subunit 1 (Ascc1)

  • 货号：
    CSB-YP002196MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP002196MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP002196MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP002196MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP002196MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ascc1
  • Uniprot No.：
  • 别名：
    Ascc1Activating signal cointegrator 1 complex subunit 1; ASC-1 complex subunit p50; Trip4 complex subunit p50
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-356
  • 氨基酸序列
    MDVLRPQIVT FDGRNYRKNP IQEKQYQHEE DEDFYPDSME YSDEPCGAYE VAQTPHGFRA TVSAPSLLYK HIVGKRGDTK KKIEVETKTS INIPKHGHEG EIVITGQHRN GVVSARTRID VLLDTFRRRQ PFTHFLSFFL NEVEVQERFL MFQEEVLRKC SKDRGVDSTI FQNPKKLHLT IGMLVLLSEQ EIQQTCEILQ RCKEEFINDI SGGRPLEVEM AGIEYMNDDP AMVDVLYAKV HMKDGSNRLQ ELVDRVLERF QSLGLIVKEW TSVKLHATVM NTLLRKDPNA EGRYNLYTAD GKYIFKERES FDGRNILKTF ENFYFGSLRL NSIHISQRFT VDSFGNYASC GHVDFS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.
  • 基因功能参考文献：
    1. homozygous and compound-heterozygous nonsense and frameshift TRIP4 and ASCC1 mutations that cosegregated with the Prenatal Spinal Muscular Atrophy and Congenital Bone Fracture phenotype PMID: 26924529
  • 亚细胞定位：
    Nucleus. Nucleus speckle.
  • 组织特异性：
    Expressed in the spinal cord, brain, paraspinal ganglia, thyroid, and submandibular glands.
  • 数据库链接：

    KEGG: mmu:69090

    STRING: 10090.ENSMUSP00000052351

    UniGene: Mm.155839