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  4. Recombinant Mouse Activating signal cointegrator 1 complex subunit 2 (Ascc2)

Recombinant Mouse Activating signal cointegrator 1 complex subunit 2 (Ascc2)

  • 货号：
    CSB-YP002197MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP002197MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP002197MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP002197MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP002197MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ascc2
  • Uniprot No.：
  • 别名：
    Ascc2; Asc1p100Activating signal cointegrator 1 complex subunit 2; ASC-1 complex subunit p100; Trip4 complex subunit p100
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-749
  • 氨基酸序列
    MPALPLDQLQ ITHKDPKTGQ PKTSAALNPE QKADRYFVLY KPPPKDNIPA LVEEYLERAN FVANDLDWLL ALPHDKFWCQ VIFDETLQKC LDSYLHYVPR KFDEWVAPTP EVADMQNHLH RSVFLTFLRM STHKESKDHF ISPSAFGEIL YNNFLFDIPK ILDLCVLFGK GNSPLLQKMI GNIFTQQPSY YTDLDETIPT ILQVFSNILQ HCGLQGDGTS TTPQKLGERS PLTPSDMPLL ELKDIVLYLC DTSTTLWAFL DIFPLACQTF QKHDFCYRLA SFYEMAIPEL ESAIKKRRLE DSKLLGDMWQ RLSHSKKKLM EVFHIILNQI CLLPILESSC DNIQGFIEEF LQIFSSLLQE KRFLRDYDTF SPVAEDISLL QQASSALDET RTAYILQAVE SAWEGVDRQK IKDIKDPPRA KGSNNEVTVT AEPVSEMPSQ LENLEEDEEC MGAAAALGPA VSGVELDSLI SQVKDLLPDL GEGFILACLE HYSYDSEQVI NNILEDRLAP ELSQLDRGLE RQVKPDPTPL LSSRHNIFQN DEFDVFSRDS VDLSRVHKGR RKEENVRSLV NDKQAVVAQW QRYQKYSVVV EEVPLQPGEY QADDYEDEYD DTYDGNQVGA NDADSDDELI SRRPFTIPQV LRTKMPGEVQ EEEWDEEDEV EEEAPKPDHF IQDPAVLREK AEARRMAFLA RKGYRPENST AVTGGPRGHG QSRETTQERR KKEANKAARA NHNRRTMADR KRSKGMIPS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. As part of the ribosome quality control trigger (RQT) complex, recognizes ZNF598-dependent ubiquitination of stalled ribosomes.
  • 基因功能参考文献：
    1. ASC-2, MLL3, and MLL4 are recruited to the PPARgamma-activated aP2 gene during adipogenesis PMID: 19047629
  • 亚细胞定位：
    Nucleus. Nucleus speckle.
  • 蛋白家族：
    ASCC2 family
  • 数据库链接：

    KEGG: mmu:75452

    STRING: 10090.ENSMUSP00000063272

    UniGene: Mm.439906