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  4. Recombinant Mouse Adenosine kinase (Adk)

Recombinant Mouse Adenosine kinase (Adk)

  • 中文名称：
    Recombinant Mouse Adenosine kinase(Adk),Yeast
  • 货号：
    CSB-YP345057MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Adenosine kinase(Adk),Yeast
  • 货号：
    CSB-EP345057MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Adenosine kinase(Adk),Yeast
  • 货号：
    CSB-EP345057MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Adenosine kinase(Adk),Yeast
  • 货号：
    CSB-BP345057MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Adenosine kinase(Adk),Yeast
  • 货号：
    CSB-MP345057MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Adk
  • Uniprot No.：
  • 别名：
    Adk; Adenosine kinase; AK; EC 2.7.1.20; Adenosine 5'-phosphotransferase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-361
  • 氨基酸序列
    MAAADEPKPK KLKVEAPQAL SENVLFGMGN PLLDISAVVD KDFLDKYSLK PNDQILAEDK HKELFDELVK KFKVEYHAGG STQNSMKVAQ WLIQEPHKAA TFFGCIGIDK FGEILKRKAA DAHVDAHYYE QNEQPTGTCA ACITGGNRSL VANLAAANCY KKEKHLDLER NWVLVEKARV YYIAGFFLTV SPESVLKVAR YAAENNRVFT LNLSAPFISQ FFKEALMDVM PYVDILFGNE TEAATFAREQ GFETKDIKEI AKKAQALPKV NSKRQRTVIF TQGRDDTIVA AENDVTAFPV LDQNQEEIID TNGAGDAFVG GFLSQLVSDK PLTECIRAGH YAASVIIRRT GCTFPEKPDF H
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
  • 基因功能参考文献：
    1. These results suggest that mice with ADK deficiency have reduced bone formation due to increased osteoclastogenesis and bone resorption. PMID: 29344645
    2. Here the s show that pro-inflammatory stimuli lead to endothelial inflammation by increasing adenosine kinase expression, and that its knockdown in endothelial cells inhibits atherosclerosis and cerebral ischemic injury in mice. PMID: 29038540
    3. ADK expression negatively regulates the adaptive beta-cell response to high-fat diet challenge. PMID: 28468960
    4. Our data show that neurological phenotypes in ADK-deficient patients are intrinsic to ADK deficiency in the brain and that blocking A2AR activity therapeutically can attenuate neurological symptoms in ADK deficiency. PMID: 27903722
    5. The findings of this study implicated a glial-neuronal circuit, mediated by Ado, neuronal AdoRA1, and glial AdK that can modulate sleep homeostasis in a manner influenced by glial metabolic state. PMID: 27030757
    6. We conclude that ADK provides important upstream regulation of adenosine-based homeostatic function of the brain PMID: 22997174
    7. Adenosine kinase inhibition selectively promotes rodent and porcine islet beta-cell replication PMID: 22345561
    8. Knockdown of Adk can protect the brain from the effects of a stroke. PMID: 21427729
    9. a complete absence of ADK led to abnormalities in hepatic adenosine metabolism and to the development of acute, severe neonatal hepatic steatosis. PMID: 11997462
    10. adenosine kinase inhibition promotes survival of fetal adenosine deaminase-deficient thymocytes by blocking dATP accumulation PMID: 12163459
    11. Overexpression of adenosine kinase in discrete parts of the epileptic hippocampus may contribute to the development and progression of seizure activity. PMID: 14736855
    12. Data report the cloning of two isoforms of adenosine kinase from a mouse brain cDNA library, and the role of these isoenzymes as sustrates for phosphorylation were examined. PMID: 15317590
    13. transient downregulation of hippocampal ADK after stroke might be a protective mechanism during maturation hippocampal cell loss. PMID: 17457365
    14. The results of this study confirmed that ADK overexpression could lead to functional concomitant alterations in dopaminergic and glutamatergic functions. PMID: 18005073
    15. These findings suggest that astrocyte-based ADK provides a critical link between astrogliosis and neuronal dysfunction in epilepsy. PMID: 18172552
    16. role for HIF-1alpha in transcriptional repression of AK in hypoxia PMID: 18309031

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  • 亚细胞定位：
    [Isoform Long]: Nucleus.; [Isoform Short]: Cytoplasm.
  • 蛋白家族：
    Carbohydrate kinase PfkB family
  • 组织特异性：
    Highest expression in liver, testis, kidney and spleen. Lower expression in brain. Isoform Long is predominant in testis and kidney and isoform Short is predominant in the spleen.
  • 数据库链接：

    KEGG: mmu:11534

    STRING: 10090.ENSMUSP00000047665

    UniGene: Mm.188734