Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Adenylyl cyclase-associated protein 1 (Cap1)

Recombinant Mouse Adenylyl cyclase-associated protein 1 (Cap1)

  • 中文名称：
    Recombinant Mouse Adenylyl cyclase-associated protein 1(Cap1),Yeast
  • 货号：
    CSB-YP004486MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Adenylyl cyclase-associated protein 1(Cap1),Yeast
  • 货号：
    CSB-EP004486MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Adenylyl cyclase-associated protein 1(Cap1),Yeast
  • 货号：
    CSB-EP004486MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Adenylyl cyclase-associated protein 1(Cap1),Yeast
  • 货号：
    CSB-BP004486MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Adenylyl cyclase-associated protein 1(Cap1),Yeast
  • 货号：
    CSB-MP004486MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cap1
  • Uniprot No.：
  • 别名：
    Cap1; Cap; Adenylyl cyclase-associated protein 1; CAP 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-474
  • 氨基酸序列
    ADMQNLVER LERAVGRLEA VSHTSDMHCG YGDSPSKGAV PYVQAFDSLL ANPVAEYLKM SKEIGGDVQK HAEMVHTGLK LERALLATAS QCQQPAGNKL SDLLAPISEQ IQEVITFREK NRGSKFFNHL SAVSESIQAL GWVALAAKPG PFVKEMNDAA MFYTNRVLKE YRDVDKKHVD WVRAYLSIWT ELQAYIKEFH TTGLAWSKTG PVAKELSGLP SGPSVGSGPP PPPPGPPPPP ISTSSGSDDS ASRSALFAQI NQGESITHAL KHVSDDMKTH KNPALKAQSG PVRSGPKPFS APKPQTSPSP KPATKKEPAL LELEGKKWRV ENQENVSNLV IDDTELKQVA YIYKCVNTTL QIKGKINSIT VDNCKKLGLV FDDVVGIVEI INSRDVKVQV MGKVPTISIN KTDGCHAYLS KNSLDCEIVS AKSSEMNVLI PTEGGDFNEF PVPEQFKTLW NGQKLVTTVT EIAG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
  • 基因功能参考文献：
    1. The structural basis of actin monomer re-charging by CAP1 protein has been reported. PMID: 29760438
    2. Phosphorylation regulates CAP1 function through association with cofilin and actin in order to control the actin cytoskeleton. PMID: 25315833
    3. a novel inhibitory interaction between CAP1/Prss8 and nexin-1, opening the search for specific CAP1/Prss8 antagonists that are independent of its catalytic activity PMID: 25138159
    4. lkj o hpoi oihl hip oihpo ih PMID: 25228691
    5. CAP1 depletion also led to changes in cofilin phosphorylation and localization as well as activation of focal adhesion kinase (FAK) and enhanced cell spreading. PMID: 23737525
    6. study provides evidence that catalyzing nucleotide exchange on actin monomers via the beta-sheet domain is the most highly conserved function of CAPs from mammals to apicomplexan parasites. PMID: 23184938
    7. CAP1 is widely expressed in mouse nonmuscle cells and promotes cofilin-induced actin dynamics. PMID: 15004221
    8. CAP1 shows a broad tissue distribution and localizes to the cytoplasm PMID: 17805484
    9. Postsynaptic adenylyl cyclase 1 is required for functional maturation of thalamocortical synapses and morphological barrels. PMID: 18524897
    10. These studies suggest that CAP1 provides a direct link from the actin cytoskeleton to the mitochondria by functioning as an actin shuttle. PMID: 18716285

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    CAP family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    KEGG: mmu:12331

    STRING: 10090.ENSMUSP00000068260

    UniGene: Mm.8687